TY  - JOUR
TI  - Evaluation of dyslipidemia in preeclamptic pregnant
women and determination of the predictive value
of the hemato-lipid profile: A prospective, cross-
sectional, case-control study
AB  - Objective: In this study, we examined the serum hematologic and lipid parameters of pregnant women with preeclampsia and an age- and gestational-age
matched normotensive control group. We also compared the ratios of hemato-lipid parameters defined as systemic inflammatory markers and determined
the predictive value of these values in preeclampsia.
Materials and Methods: All patients diagnosed with late-onset preeclampsia or severe preeclampsia between 34 and 40 weeks of gestation at Inonu
University Faculty of Medicine between March 2019 and October 2020 were included.
Results: A total of 253 pregnant women were included in the study period. When the study groups were compared in terms of hematological and blood
lipid profile; while serum lymphocyte, triglyceride, and total cholesterol levels were significantly higher in the preeclampsia group than in the control
group (p<0.001, p<0.001, p=0.013, respectively); high-density lipoprotein (HDL)-cholesterol levels were found to be significantly lower (p=0.017). The
cut-off value for the monocyte/HDL ratio in predicting severe preeclampsia was 16.65 with 59.0% sensitivity and 85.4% specificity [the area under the
receiver operating characteristic 0.756, 95% confidence interval (CI) 0.681-0.821, p<0.001]. Multivariate analysis showed that the monocyte/HDL ratio
was independently associated with both preeclampsia and severe preeclampsia [odds ratio (OR): 1.094; 95% CI 1.009-1.185 and OR: 1.731; 95% CI
1.218-2.459, respectively].
Conclusion: This study demonstrated that serum triglyceride and total cholesterol levels were significantly higher and serum HDL-cholesterol levels were
significantly lower in pregnant women with late-onset preeclampsia compared to normotensive pregnant women. Additionally, this study revealed that the
measurement of monocyte/HDL ratio in the pregnant population could be a useful clinical tool for predicting preeclampsia.
AU  - Özdemir, Halis
AU  - ZEYVELI CELIK, NESIBE
AU  - YAŞAR, Şeyma
AU  - MELEKOGLU, RAUF
DO  - 10.4274/tjod.galenos.2022.36744
PY  - 2022
JO  - Turkish Journal of Obstetrics and Gynecology
VL  - 19
IS  - 1
SN  - 2149-9322
SP  - 7
EP  - 20
DB  - TRDizin
UR  - http://search/yayin/detay/523960
ER  -