TY  - JOUR
TI  - Retinal Nerve Fiber Layer Thickness in Prediabetic Patients
AB  - Objective: Diabetic retinopathy is a leading cause of blindness. Diabetic retinopathy is not only 
seen in diabetic patients with the clinical diagnosis but also in prediabetic patients. The aim of this 
study is to evaluate the RNFL thickness in prediabetic patients.
Materials and Methods: In this study, 50 prediabetic patients and 50 healthy individuals were 
included. RNFL measurements were performed with SD-OCT in patients with prediabetes and 
healthy controls.
Results: The mean RNFL thickness for the prediabetic group was 94.7 ± 6.3 μm, inferior quadrant (120 ± 11.6), superior quadrant (112.3 ± 14.13), nasal quadrant (71 ± 12.9), and temporal 
quadrant (65.3 ± 9.2 μm). The mean RNFL thickness for the control group was 98.9 ± 7.5 μm, 
inferior quadrant (128 ± 14.7), superior quadrant (116.3 ± 15.12), nasal quadrant (77 ± 15.8), 
and temporal quadrant (71.2 ± 10.3 μm). Variance analysis demonstrated that the RNFL thickness difference between the groups was significant in all quadrants (P < .001).
Conclusion: RNLF thinning can be seen in prediabetic patients before obvious vascular damage 
has occurred, and it may present in prediabetic patients not only in the temporal quadrant but 
also in all quadrants. The early retinal neural changes shown in this study in prediabetic patients 
may help to better understand the process leading to diabetic overt retinopathy.
AU  - CAPOGLU, Ilyas
AU  - BİLEN, Arzu
AU  - ates, orhan
AU  - bilen, habib
AU  - ONDAŞ, Osman
DO  - 10.5152/eurasianjmed.2022.20420
PY  - 2022
JO  - Eurasian Journal of Medicine
VL  - 54
IS  - 1
SN  - 1308-8734
SP  - 8
EP  - 11
DB  - TRDizin
UR  - http://search/yayin/detay/524226
ER  -