TY  - JOUR
TI  - Increased vitamin D binding protein levels
are associated with irritable bowel
syndrome
AB  - identify Irritable bowel syndrome (IBS) and its subtypes.
The aim of this study is to explore potential serum biomarkers
that may be associated with IBS subtypes, particularly
in the vitamin D pathway.
Methods: The study population comprised 75 IBS patients
and 79 controls. Patients divided into IBS subtypes. Routine
biochemical parameters, 25-OH-vitamin D, vitamin D
binding protein (VDBP) and vitamin D receptor (VDR)
serum levels were compared between IBS subtypes and
controls. Factors related to IBS subtypes were examined by
multivariate logistic regression analysis.
Results: Vitamin D levels were lower; VDBP and VDR were
higher in all IBS patients than in controls (p<0.001; 0.047
and 0.029, respectively). According to logistic regression analysis, VDBP was a disease-related parameter as much
as vitamin D in all IBS subtypes. C-reactive protein (CRP)
and erythrocyte sedimentation rate (ESR) were higher
especially in diarrhea-dominant IBS (IBS-D) (p=0.041;
0.046) and vitamin B12 were significantly lower in
constipation-dominant IBS (IBS-C) (p=0.001).
Conclusions: Increased VDBP levels were associated with
all IBS subtypes. Patients, especially in IBS-D, had higher
serum levels of VDBP, CRP and ESR. Vitamin B12 deficiency,
which we consider as a result of the disease, was
more common in IBS-C.
AU  - BÖREKÇİ, Hasan
AU  - BAŞ, Hatice
AU  - YILDIRIM, Tekin
AU  - Kılıç, Mahmut
AU  - GÖÇMEN, Yeşim
AU  - Börekci, Elif
AU  - OZAN, Zeynep
DO  - 10.1515/tjb-2020-0305
PY  - 2021
JO  - Türk Biyokimya Dergisi
VL  - 46
IS  - 4
SN  - 1303-829X
SP  - 415
EP  - 424
DB  - TRDizin
UR  - http://search/yayin/detay/524227
ER  -