Effects of resveratrol against scattered
radiation-induced testicular damage in rats

Sener, Tarik Emre; ÇEVİK, Özge; ATASOY, Beste Melek; Cilingir-Kaya, Ozlem Tugce

doi:10.1515/tjb-2020-0320

Effects of resveratrol against scattered radiation-induced testicular damage in rats

Tarık ŞENER, (Marmara Üniversitesi, Tıp Fakültesi, Üroloji Anabilim Dalı, İstanbul, Türkiye)

Beste Melek ATASOY, (Marmara Üniversitesi, Tıp Fakültesi, Radyasyon Bölümü Onkoloji, İstanbul, Türkiye)

Özge ÇEVİK, (Adnan Menderes Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Aydın, Türkiye)

Özlem Tuğçe ÇİLİNGİR KAYA (Marmara Üniversitesi, Tıp Fakültesi, Histoloji Anabilim Dalı Embriyoloji, İstanbul, Türkiye)

Türk Biyokimya Dergisi

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Yıl: 2021 Cilt: 46 Sayı: 4 Sayfa Aralığı: 425 - 433 Metin Dili: İngilizce DOI: 10.1515/tjb-2020-0320 İndeks Tarihi: 24-06-2022

Effects of resveratrol against scattered radiation-induced testicular damage in rats

Öz:

Objectives: To investigate the possible protective effects of resveratrol against oxidative testicular damage due to scattered radiation during pelvic ionizing radiation exposure in rats. Methods: Rats were divided into 5 groups; control, radiation, and radiation + resveratrol therapy in early and late periods. Under anesthesia, 20 Gy ionizing radiation was applied to prostatic region. Resveratrol was administered (10 mg/kg/day) orally before ionizing radiation exposure. Animals were decapitated at the end of 1st and 10th weeks. Biochemical markers of oxidative stress; caspase-3 and sirtuin-1 protein expressions; testosterone levels were evaluated, histological examinations were performed. Results: Significant increases in malondialdehyde, 8-hydroxy-deoxyguanosine levels, myeloperoxidase, and caspase-3 activities were observed after ionizing radiation exposure, also superoxide dismutase and glutathione activities were significantly decreased. Radiotherapy increased caspase-3 and decreased sirtuin-1 protein expressions. Resveratrol treatment significantly reversed these parameters and also reversed the decrease in testosterone levels back to control levels in late period. Conclusion: Resveratrol showed antioxidant and sirtuinactivating properties against oxidative damage caused by scattered radiation to testis and provided hormonal protection. These results suggest that resveratrol may be an alternative protective agent on testicular tissues against the effects of scattered pelvic radiation.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Sener T, ATASOY B, ÇEVİK Ö, Cilingir-Kaya O (2021). Effects of resveratrol against scattered radiation-induced testicular damage in rats. , 425 - 433. 10.1515/tjb-2020-0320
Chicago	Sener Tarik Emre,ATASOY Beste Melek,ÇEVİK Özge,Cilingir-Kaya Ozlem Tugce Effects of resveratrol against scattered radiation-induced testicular damage in rats. (2021): 425 - 433. 10.1515/tjb-2020-0320
MLA	Sener Tarik Emre,ATASOY Beste Melek,ÇEVİK Özge,Cilingir-Kaya Ozlem Tugce Effects of resveratrol against scattered radiation-induced testicular damage in rats. , 2021, ss.425 - 433. 10.1515/tjb-2020-0320
AMA	Sener T,ATASOY B,ÇEVİK Ö,Cilingir-Kaya O Effects of resveratrol against scattered radiation-induced testicular damage in rats. . 2021; 425 - 433. 10.1515/tjb-2020-0320
Vancouver	Sener T,ATASOY B,ÇEVİK Ö,Cilingir-Kaya O Effects of resveratrol against scattered radiation-induced testicular damage in rats. . 2021; 425 - 433. 10.1515/tjb-2020-0320
IEEE	Sener T,ATASOY B,ÇEVİK Ö,Cilingir-Kaya O "Effects of resveratrol against scattered radiation-induced testicular damage in rats." , ss.425 - 433, 2021. 10.1515/tjb-2020-0320
ISNAD	Sener, Tarik Emre vd. "Effects of resveratrol against scattered radiation-induced testicular damage in rats". (2021), 425-433. https://doi.org/10.1515/tjb-2020-0320

APA	Sener T, ATASOY B, ÇEVİK Ö, Cilingir-Kaya O (2021). Effects of resveratrol against scattered radiation-induced testicular damage in rats. Türk Biyokimya Dergisi, 46(4), 425 - 433. 10.1515/tjb-2020-0320
Chicago	Sener Tarik Emre,ATASOY Beste Melek,ÇEVİK Özge,Cilingir-Kaya Ozlem Tugce Effects of resveratrol against scattered radiation-induced testicular damage in rats. Türk Biyokimya Dergisi 46, no.4 (2021): 425 - 433. 10.1515/tjb-2020-0320
MLA	Sener Tarik Emre,ATASOY Beste Melek,ÇEVİK Özge,Cilingir-Kaya Ozlem Tugce Effects of resveratrol against scattered radiation-induced testicular damage in rats. Türk Biyokimya Dergisi, vol.46, no.4, 2021, ss.425 - 433. 10.1515/tjb-2020-0320
AMA	Sener T,ATASOY B,ÇEVİK Ö,Cilingir-Kaya O Effects of resveratrol against scattered radiation-induced testicular damage in rats. Türk Biyokimya Dergisi. 2021; 46(4): 425 - 433. 10.1515/tjb-2020-0320
Vancouver	Sener T,ATASOY B,ÇEVİK Ö,Cilingir-Kaya O Effects of resveratrol against scattered radiation-induced testicular damage in rats. Türk Biyokimya Dergisi. 2021; 46(4): 425 - 433. 10.1515/tjb-2020-0320
IEEE	Sener T,ATASOY B,ÇEVİK Ö,Cilingir-Kaya O "Effects of resveratrol against scattered radiation-induced testicular damage in rats." Türk Biyokimya Dergisi, 46, ss.425 - 433, 2021. 10.1515/tjb-2020-0320
ISNAD	Sener, Tarik Emre vd. "Effects of resveratrol against scattered radiation-induced testicular damage in rats". Türk Biyokimya Dergisi 46/4 (2021), 425-433. https://doi.org/10.1515/tjb-2020-0320