TY  - JOUR
TI  - Effects of resveratrol against scattered
radiation-induced testicular damage in rats
AB  - Objectives: To investigate the possible protective effects
of resveratrol against oxidative testicular damage due to
scattered radiation during pelvic ionizing radiation exposure
in rats.
Methods: Rats were divided into 5 groups; control, radiation,
and radiation + resveratrol therapy in early and late
periods. Under anesthesia, 20 Gy ionizing radiation was
applied to prostatic region. Resveratrol was administered
(10 mg/kg/day) orally before ionizing radiation exposure.
Animals were decapitated at the end of 1st and 10th weeks.
Biochemical markers of oxidative stress; caspase-3 and
sirtuin-1 protein expressions; testosterone levels were evaluated,
histological examinations were performed.
Results: Significant increases in malondialdehyde,
8-hydroxy-deoxyguanosine levels, myeloperoxidase, and caspase-3 activities were observed after ionizing radiation
exposure, also superoxide dismutase and glutathione activities
were significantly decreased. Radiotherapy increased
caspase-3 and decreased sirtuin-1 protein expressions.
Resveratrol treatment significantly reversed these parameters
and also reversed the decrease in testosterone levels
back to control levels in late period.
Conclusion: Resveratrol showed antioxidant and sirtuinactivating
properties against oxidative damage caused by
scattered radiation to testis and provided hormonal protection.
These results suggest that resveratrol may be an
alternative protective agent on testicular tissues against
the effects of scattered pelvic radiation.
AU  - Sener, Tarik Emre
AU  - ÇEVİK, Özge
AU  - ATASOY, Beste Melek
AU  - Cilingir-Kaya, Ozlem Tugce
DO  - 10.1515/tjb-2020-0320
PY  - 2021
JO  - Türk Biyokimya Dergisi
VL  - 46
IS  - 4
SN  - 1303-829X
SP  - 425
EP  - 433
DB  - TRDizin
UR  - http://search/yayin/detay/524230
ER  -