The effects of oral steroid therapy on
prolidase enzyme activity in patients
with nasal polyps

Özcan, Müge; KAYADİBİ, Hüseyin; DEMİR, Emre; EKİNCİ, ADNAN

doi:10.1515/tjb-2019-0204

The effects of oral steroid therapy on prolidase enzyme activity in patients with nasal polyps

Adnan EKİNCİ, (Hitit Üniversitesi Tıp Fakültesi, Kulak Burun Boğaz Anabilim Dalı, Çorum, Türkiye)

Hüseyin KAYADİBİ, (Hitit Üniversitesi Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Çorum, Türkiye)

Emre DEMİR, (Hitit Üniversitesi Tıp Fakültesi Anabilim Dalı Biyoistatistik, Çorum, Türkiye)

Müge ÖZCAN (Ankara Numune Eğitim ve Araştırma Hastanesi, Kulak Burun Boğaz Kliniği, Ankara, Türkiye)

Türk Biyokimya Dergisi

1 1

Yıl: 2021 Cilt: 46 Sayı: 4 Sayfa Aralığı: 473 - 477 Metin Dili: İngilizce DOI: 10.1515/tjb-2019-0204 İndeks Tarihi: 24-06-2022

The effects of oral steroid therapy on prolidase enzyme activity in patients with nasal polyps

Öz:

Objective: To compare prolidase enzyme activity (PEA) in serum and polyp specimens of patients with nasal polyps obtained before and after the oral steroid therapy. Materials and methods: Thirty three patients with nasal polyps (39 ± 13 years) received 1 mg/kg of oral steroids. Serum samples were collected from each patient, but nasal polyp specimens could be obtained only from 23 patients (38 ± 13 years) before and after the oral steroid therapy. PEA was measured by ELISA method. Results: Serum PEA values were 210 (176–242) U/L and 184 (147–217) U/L before and after the oral steroid therapy, respectively (p = 0.015). Polyp tissue PEA was 1337 (738–2130) U/g and 871 (590–1663) U/g before and after the oral steroid therapy, respectively (p = 0.429). Conclusion: In patients with nasal polyps, significantly lower serum PEA after the oral steroid therapy may be a consequence of the role of prolidase enzyme in inflammatory processes which are important for the development of nasal polyps. More comprehensive studies with larger sample sizes are needed to elucidate the role of PEA in the pathogenesis of nasal polyps.

Anahtar Kelime:

Nazal polipli hastalarda oral steroid tedavisinin prolidaz enzim aktivitesi üzerine etkisi

Öz:

Amaç: Nazal polip hastalarının serum ve burun polip dokusu örneklerinde steroid tedavisinden önce ve sonra prolidaz enzim aktivitesini karşılaştırmaktır. Gereç ve Yöntem: Nazal polipli 33 hasta (39 ± 13 yıl) 1 mg/kg oral steroid tedavisi aldı. Oral steroid tedavisi öncesi ve sonrasında her bir hastadan serum örnekleri alınabilirken, sadece 23 hastadan (38 ± 13 yıl) nazal polip dokusu örnekleri alınabildi. Prolidaz enzim aktivitesi ELISA yöntemiyle ölçüldü. Bulgular: Serum prolidaz enzim aktivitesi tedavi öncesi 210 (176–242) U/L iken tedavi sonrası 184 (147–217) U/L idi (p = 0.015). Nazal polip dokusundaki prolidaz enzim aktivitesi ise tedavi öncesi 1.337 (738–2.130) U/g iken tedavi sonrası 871 (590–1.663) U/g idi (p = 0.429). Sonuç: Nazal polipli hastalarda oral steroid tedavisinden sonra görülen anlamlı derecede daha düşük serum prolidaz enzim aktivitesi nazal polip gelişimi için önemli olan enflamatuar süreçlerde prolidaz enzim aktivitesinin bir rolünün olmasından dolayı olabilir. Nazal poliplerin patogenezinde prolidaz enzim aktivitesinin rolünü açıklığa kavuşturmak için daha fazla hastayla daha detaylı çalışmalar yapılması gerekir.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	EKİNCİ A, KAYADİBİ H, DEMİR E, Özcan M (2021). The effects of oral steroid therapy on prolidase enzyme activity in patients with nasal polyps. , 473 - 477. 10.1515/tjb-2019-0204
Chicago	EKİNCİ ADNAN,KAYADİBİ Hüseyin,DEMİR Emre,Özcan Müge The effects of oral steroid therapy on prolidase enzyme activity in patients with nasal polyps. (2021): 473 - 477. 10.1515/tjb-2019-0204
MLA	EKİNCİ ADNAN,KAYADİBİ Hüseyin,DEMİR Emre,Özcan Müge The effects of oral steroid therapy on prolidase enzyme activity in patients with nasal polyps. , 2021, ss.473 - 477. 10.1515/tjb-2019-0204
AMA	EKİNCİ A,KAYADİBİ H,DEMİR E,Özcan M The effects of oral steroid therapy on prolidase enzyme activity in patients with nasal polyps. . 2021; 473 - 477. 10.1515/tjb-2019-0204
Vancouver	EKİNCİ A,KAYADİBİ H,DEMİR E,Özcan M The effects of oral steroid therapy on prolidase enzyme activity in patients with nasal polyps. . 2021; 473 - 477. 10.1515/tjb-2019-0204
IEEE	EKİNCİ A,KAYADİBİ H,DEMİR E,Özcan M "The effects of oral steroid therapy on prolidase enzyme activity in patients with nasal polyps." , ss.473 - 477, 2021. 10.1515/tjb-2019-0204
ISNAD	EKİNCİ, ADNAN vd. "The effects of oral steroid therapy on prolidase enzyme activity in patients with nasal polyps". (2021), 473-477. https://doi.org/10.1515/tjb-2019-0204

APA	EKİNCİ A, KAYADİBİ H, DEMİR E, Özcan M (2021). The effects of oral steroid therapy on prolidase enzyme activity in patients with nasal polyps. Türk Biyokimya Dergisi, 46(4), 473 - 477. 10.1515/tjb-2019-0204
Chicago	EKİNCİ ADNAN,KAYADİBİ Hüseyin,DEMİR Emre,Özcan Müge The effects of oral steroid therapy on prolidase enzyme activity in patients with nasal polyps. Türk Biyokimya Dergisi 46, no.4 (2021): 473 - 477. 10.1515/tjb-2019-0204
MLA	EKİNCİ ADNAN,KAYADİBİ Hüseyin,DEMİR Emre,Özcan Müge The effects of oral steroid therapy on prolidase enzyme activity in patients with nasal polyps. Türk Biyokimya Dergisi, vol.46, no.4, 2021, ss.473 - 477. 10.1515/tjb-2019-0204
AMA	EKİNCİ A,KAYADİBİ H,DEMİR E,Özcan M The effects of oral steroid therapy on prolidase enzyme activity in patients with nasal polyps. Türk Biyokimya Dergisi. 2021; 46(4): 473 - 477. 10.1515/tjb-2019-0204
Vancouver	EKİNCİ A,KAYADİBİ H,DEMİR E,Özcan M The effects of oral steroid therapy on prolidase enzyme activity in patients with nasal polyps. Türk Biyokimya Dergisi. 2021; 46(4): 473 - 477. 10.1515/tjb-2019-0204
IEEE	EKİNCİ A,KAYADİBİ H,DEMİR E,Özcan M "The effects of oral steroid therapy on prolidase enzyme activity in patients with nasal polyps." Türk Biyokimya Dergisi, 46, ss.473 - 477, 2021. 10.1515/tjb-2019-0204
ISNAD	EKİNCİ, ADNAN vd. "The effects of oral steroid therapy on prolidase enzyme activity in patients with nasal polyps". Türk Biyokimya Dergisi 46/4 (2021), 473-477. https://doi.org/10.1515/tjb-2019-0204