TY  - JOUR
TI  - The effects of oral steroid therapy on
prolidase enzyme activity in patients
with nasal polyps
AB  - Objective: To compare prolidase enzyme activity (PEA) in
serum and polyp specimens of patients with nasal polyps
obtained before and after the oral steroid therapy.
Materials and methods: Thirty three patients with nasal
polyps (39 ± 13 years) received 1 mg/kg of oral steroids.
Serum samples were collected from each patient, but
nasal polyp specimens could be obtained only from
23 patients (38 ± 13 years) before and after the oral steroid
therapy. PEA was measured by ELISA method.
Results: Serum PEA values were 210 (176–242) U/L
and 184 (147–217) U/L before and after the oral steroid
therapy, respectively (p = 0.015). Polyp tissue PEA was
1337 (738–2130) U/g and 871 (590–1663) U/g before and
after the oral steroid therapy, respectively (p = 0.429).
Conclusion: In patients with nasal polyps, significantly
lower serum PEA after the oral steroid therapy may be a
consequence of the role of prolidase enzyme in inflammatory
processes which are important for the development
of nasal polyps. More comprehensive studies with larger
sample sizes are needed to elucidate the role of PEA in the
pathogenesis of nasal polyps.
AU  - Özcan, Müge
AU  - KAYADİBİ, Hüseyin
AU  - DEMİR, Emre
AU  - EKİNCİ, ADNAN
DO  - 10.1515/tjb-2019-0204
PY  - 2021
JO  - Türk Biyokimya Dergisi
VL  - 46
IS  - 4
SN  - 1303-829X
SP  - 473
EP  - 477
DB  - TRDizin
UR  - http://search/yayin/detay/524249
ER  -