Focus on natural pesticides from the necm tree, Azadirachta indica A. Juss (Meliaceae) In light of the extensive literature on different aspects of neem products, this review is by no means meant to be exclusive. It merely reflects a general view of neem products. It gives few examples to highlight and illustrate the potentiality, feasibility and promising utility of neem derivatives and their possibilities of manipulating or killing pests. The neem derivatives have been found to possess pest control properties that in¬clude antifeedant, antiovipositional, growth regulatory and lethal toxic activities against a wide variety of pests. These pests include agricultural, stored products and house-hold pests in addition to vectors of animal and human diseases. The neem derivatives are primarily considered as feeding-toxicants for larvae or nymphs of phytophagous insects and hence show considerable selectivity toward natural enemies and biocontrol agents such as parasitoids and predators. In relation to biological interaction, the detrimental effects of neem derivative are strongly enhanced by the presence of entomopathogens such as Bacillus thuringiensis. Owing to their effectiveness against pests, biodegradation, considerable selectivity, harmlessness to benefical and non target organisms, neem derivatives could be a potential component in integrated pest management.