Mediating effect of disease severity on the relationship between smoking status and quality of life in psoriasis patients
Yıl: 2022 Cilt: 47 Sayı: 2 Sayfa Aralığı: 792 - 799 Metin Dili: İngilizce DOI: 10.17826/cumj.1088577 İndeks Tarihi: 29-07-2022
Mediating effect of disease severity on the relationship between smoking status and quality of life in psoriasis patients
Öz: Purpose: The aim of this study was to examine the relationship between smoking and quality of life and to investigate the mediating role of disease severity on this relationship in psoriasis patients.
Materials and Methods: In the study, 268 psoriasis patients were reached by the convenience sampling method. In the study, patients' quality of life was measured with “dermatology quality of life index (DLQI)” and disease severity was measured with “psoriasis area and severity index (PASI)”. The effect of the independent variable (smoking) on the dependent variable (quality of life), both directly and indirectly through the mediating variable (disease severity), was examined by process analysis.
Results: Smoking status shows statistically significant differences according to gender, age, marital status, occupation, and income groups. 17.02% of women and 44.09% of men smoke.19.74% of single and 33.85% of married smoke. 20% of unemployed and 39.13% of employees smoke. 17.76% of low-income, 50.91% of middle-income, and 40.98% of high-income people smoke. This cross-sectional study revealed that smoking in psoriasis has no direct effect on the quality of life, but that smoking has a full indirect effect on the quality of life through disease severity.
Conclusion: In the study, it was found that smoking negatively affects the quality of life through both disease severity. Accordingly, it is recommended that patients be informed about the effect of smoking on their diseases.
Anahtar Kelime: Psoriasis hastalarında sigara içme durumu ile yaşam kalitesi arasındaki ilişkide hastalık şiddetinin aracı etkisi
Öz: Amaç: Bu çalışmada, psoriasis hastalarında sigara kullanımı ile yaşam kalitesi arasındaki ilişkinin incelenmesi ve bu ilişkide hastalık şiddetinin aracı rolünün araştırılması amaçlanmıştır.
Gereç ve Yöntem: Çalışmada 268 psoriasis hastasına kolayda örnekleme yöntemi ile ulaşılmıştır. Çalışmada hastaların yaşam kaliteleri “dermatoloji yaşam kalite indeksi (DLQI)” ve hastalık şiddetleri ise “psoriasis alan ve şiddet indeksi (PASI)” ile ölçülmüştür. Ayrıca bağımsız değişkenin (sigara içme) bağımlı değişken (yaşam kalitesi) üzerindeki etkisi, hem doğrudan etkisi hem de aracı değişken (hastalık şiddeti) aracılığıyla dolaylı etkisi süreç analizi ile incelenmiştir.
Bulgular: Sigara kullanma durumu cinsiyete, yaşa, medeni durumuna, mesleğe ve gelir gruplarına göre istatistiksel olarak anlamlı farklılık göstermektedir. Kadınların %17,02'si ve erkeklerin %44,09'u sigara içmektedir. Bekârların %19.74'ü ve evlilerin %33.85'i sigara içmektedir. İşsizlerin %20'si ve çalışanların %39,13'ü sigara içmektedir. Düşük gelirlilerin %17,76'sı, orta gelirlilerin %50,91'i ve yüksek gelirlilerin %40,98'i sigara içmektedir. Çalışmada temel olarak psoriasis hastalığında sigara içmenin yaşam kalitesi üzerinde doğrudan bir etkisinin olmadığı, ancak sigara içmenin hastalık şiddeti aracılığıyla yaşam kalitesi üzerinde dolaylı tam bir etkisinin olduğunu bulunmuştur.
Sonuç: Çalışmada sigara içmenin hem hastalık şiddeti aracılığıyla yaşam kalitesini olumsuz etkilediği bulunmuştur. Buna göre hastalar sigara içmenin hastalıkları üzerindeki etkisi konusunda bilgilendirilmesi önerilmektedir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- 1. WHO. Global Report on Psoriasis. Geneva, World Health Organization, 2016.
- 2. Griffiths CE, Armstrong AW, Gudjonsson JE, Barker JN. Psoriasis. Lancet. 2021; 397:1301-1315.
- 3. Seldin MF. The genetics of human autoimmune disease: a perspective on progress in the field and future directions. J Autoimmun. 2015;64:1-12.
- 4. Dika E, Bardazzi F, Balestri R, Maibach HI. Environmental factors and psoriasis. Curr Probl Dermatol. 2007;35:118-135.
- 5. Lee EB, Wu KK, Lee MP, Bhutani T, Wu JJ. Psoriasis risk factors and triggers. Cutis. 2018;102:18-20.
- 6. Zeng J, Luo S, Huang Y, Lu Q. Critical role of environmental factors in the pathogenesis of psoriasis. J Dermatol. 2017;44:863-872.
- 7. Barrea L, Nappi F, Di Somma C, et al. Environmental risk factors in psoriasis: the point of view of the nutritionist. Int J Environ Res Public Health. 2016;13:743.
- 8. Raychaudhuri SP, Gross J. Psoriasis risk factors: role of lifestyle practices. Cutis. 2000; 66:348-352.
- 9. Jankovic S, Raznatovic M, Marinkovic J, Jankovic J, Maksimovic N. Risk factors for psoriasis: a case– control study. J Dermatol. 2009;36:328-334.
- 10. Heller MM, Lee ES, Koo JY. Stress as an influencing factor in psoriasis. Skin Therapy Lett. 2011;16:1-4.
- 11. Jankowiak B, Kowalewska B, Krajewska-Kułak E, Khvorik DF. Stigmatization and quality of life in patients with psoriasis. Dermatol Ther. 2020;10:285- 296.
- 12. Roszkiewicz M, Dopytalska K, Szymanska E, Jakimiuk A, Walecka I. Environmental risk factors and epigenetic alternations in psoriasis. Ann Agric Environ Med. 2020;27:335-342.
- 13. Amoruso GF, Nisticò SP, Iannone L, Russo E, Rago G, Patruno C et al. Ixekizumab may improve renal function in psoriasis. Healthcare. 2021;9:543-548.
- 14. Constantin MM, Bucur S, Mutu CC, Poenaru E, Olteanu R, Ionescu RA et al. The ımpact of smoking on psoriasis patients with biological therapies in a Bucharest Hospital. J Pers Med. 2021;11:752-762.
- 15. Fortes C, Mastroeni S, Leffondré K, Sampogna F, Melchi F, Mazzotti E et al. Relationship between smoking and the clinical severity of psoriasis. AMA Arch Derm. 2005;141:1580-1584.
- 16. Attwa E, Swelam E. Relationship between smoking‐ induced oxidative stress and the clinical severity of psoriasis. J Eur Acad Dermatol Venereol. 2011;25:782-787.
- 17. Emre S, Metin A, Demirseren DD, Kilic S, Isikoglu S, Erel O. The relationship between oxidative stress, smoking and the clinical severity of psoriasis. J Eur Acad Dermatol Venereol. 2013;27:370-375.
- 18. Hayran Y, Yalçın B. Smoking habits amongst patients with psoriasis and the effect of smoking on clinical and treatment‐associated characteristics: A cross‐ sectional study. Int J Clin Pract Suppl. 2021:75:e13751.
- 19. Temiz SA, Özer İ, Ataseven A, Dursun R, Uyar M. The effect of smoking on the psoriasis: Is it related to nail involvement? Dermatol Ther. 2020;33:e13960.
- 20. Choi J, Koo JY. Quality of life issues in psoriasis. J Am Acad Dermatol. 2003;49:57-61.
- 21. Tan X, Feldman SR, Balkrishnan R. Quality of life issues and measurement in patients with psoriasis. Psoriasis Targets Ther. 2012;2:13-23.
- 22. Obradors M, Blanch C, Comellas M, Figueras M, Lizan L. Health-related quality of life in patients with psoriasis: a systematic review of the European literature. Qual Life Res. 2016;25:2739-2754.
- 23. Bhosle MJ, Kulkarni A, Feldman SR, Balkrishnan R. Quality of life in patients with psoriasis. Health Qual Life Outcomes. 2006;4:1-7.
- 24. Mattei PL, Corey KC, Kimball AB. Psoriasis Area Severity Index (PASI) and the Dermatology Life Quality Index (DLQI): the correlation between disease severity and psychological burden in patients treated with biological therapies. J Eur Acad Dermatol Venereol. 2014;28:333-337.
- 25. Sampogna F, Tabolli S, Söderfeldt B, Axtelius B, Aparo U, Abeni D et al. Multipurpose Psoriasis Research on Vital Experiences (IMPROVE) investigators. Measuring quality of life of patients with different clinical types of psoriasis using the SF‐36. Br J Dermatol. 2006;154:844-849.
- 26. Jankovic S, Raznatovic M, Marinkovic J, Jankovic, J, Kocev, N, Tomic-Spiric V et al. Health-related quality of life in patients with psoriasis. J Cutan Med Surg. 2011;15:29-36.
- 27. Çakmur H, Derviş E. The relationship between quality of life and the severity of psoriasis in Turkey. Eur J Dermatol. 215;25:169-176.
- 28. Fredriksson T, Pettersson U. Severe psoriasis–oral therapy with a new retinoid. Dermatology. 1978;157:238-244.
- 29. Finlay AY, Khan G. Dermatology Life Quality Index (DLQI)—a simple practical measure for routine clinical use. Clin Exp Dermatol. 1994;19:210-216.
- 30. Öztürkcan S, Ermertcan AT, Eser E, Turhan Şahin M. Cross validation of the Turkish version of dermatology life quality index. Int J Dermatol. 2006; 45:1300-1307.
- 31. Hayes AF. Introduction to Mediation, Moderation, and Conditional Process Analysis: A RegressionBased Approach, New York, Guilford Publications, 2018.
- 32. Kayiran N, Korkmaz S, Özgöztasi O. Plak tip psoriasis hastalarinda sigaranin hastalik siddeti üzerine etkisi/Impact of smoking on disease severity in patients with plaque type psoriasis. Turkderm-Turkish Archives of Dermatology and Venereology. 2015;49:19.
- 33. Higgins E. Alcohol, smoking and psoriasis. Clin Exp Dermatol. 2000;25:107-110.
- 34. Ryder MI, Saghizadeh M, Ding Y, Nguyen N, Soskolne A. Effects of tobacco smoke on the secretion of interleukin‐1β, tumor necrosis factor‐α, and transforming growth factor‐β from peripheral blood mononuclear cells. Oral Microbiol Immunol. 2002;17:331-336.
- 35. Ahdout J, Kotlerman J, Elashoff D, Kim J, Chiu MW. Modifiable lifestyle factors associated with metabolic syndrome in patients with psoriasis. Clin Exp Dermatol. 2012;37:477-83.
- 36. Demirseren DD, Emre S, Akoğlu G, Kılıç S, Metin A. Evaluation of effects of smoking and body mass index on clinical severity of psoriasis. Proceedings of 21st Congress of the EADV, January 2012, p.27-30.
- 37. Neimann AL, Shin DB, Wang X, Margolis DJ, Troxel AB, Gelfand JM. Prevalence of cardiovascular risk factors in patients with psoriasis. J Am Acad Dermatol. 2006;55:829-835.
- 38. Wolk K, Haugen HS, Xu W, Witte E, Waggie K, Anderson M et al. IL-22 and IL-20 are key mediators of the epidermal alterations in psoriasis while IL-17 and IFN-γ are not. J Mol Med. 2009;87:523-536.
- 39. Rakhesh SV, D'Souza M, Sahai A. Quality of life in psoriasis: a study from south India. Indian J Dermatol Venereol Leprol. 2008;74:600-606.
- 40. Aghaei S, Moradi A, Ardekani GS. Impact of psoriasis on quality of life in Iran. Indian J Dermatol Venereol Leprol. 2009;75:220-224.
- 41. Çakmur H, Derviş E. The relationship between quality of life and the severity of psoriasis in Turkey. Eur J Dermatol. 2015;25:169–176.
- 42. Koryürek ÖM, Togral AK, Koryürek MM, Eksioglu HM. Türk psoriasis hastalarinda yasam kalitesini etkileyen faktörler. Turk Dermatoloji Dergisi. 2015;9:123.
- 43. Al Raddadi A, Jfri A, Samarghandi S, Matury N, Habibullah T, Alfarshoti M, Mahdi A. (Psoriasis: Correlation between severity index (PASI) and quality of life index (DLQI) based on the type of treatment. Journal of Dermatology & Dermatologic Surgery. 2016;20:15-18.
| APA | Tosun M, İlgün G, tosun n (2022). Mediating effect of disease severity on the relationship between smoking status and quality of life in psoriasis patients. , 792 - 799. 10.17826/cumj.1088577 |
| Chicago | Tosun Mustafa,İlgün Gülnur,tosun nurperihan Mediating effect of disease severity on the relationship between smoking status and quality of life in psoriasis patients. (2022): 792 - 799. 10.17826/cumj.1088577 |
| MLA | Tosun Mustafa,İlgün Gülnur,tosun nurperihan Mediating effect of disease severity on the relationship between smoking status and quality of life in psoriasis patients. , 2022, ss.792 - 799. 10.17826/cumj.1088577 |
| AMA | Tosun M,İlgün G,tosun n Mediating effect of disease severity on the relationship between smoking status and quality of life in psoriasis patients. . 2022; 792 - 799. 10.17826/cumj.1088577 |
| Vancouver | Tosun M,İlgün G,tosun n Mediating effect of disease severity on the relationship between smoking status and quality of life in psoriasis patients. . 2022; 792 - 799. 10.17826/cumj.1088577 |
| IEEE | Tosun M,İlgün G,tosun n "Mediating effect of disease severity on the relationship between smoking status and quality of life in psoriasis patients." , ss.792 - 799, 2022. 10.17826/cumj.1088577 |
| ISNAD | Tosun, Mustafa vd. "Mediating effect of disease severity on the relationship between smoking status and quality of life in psoriasis patients". (2022), 792-799. https://doi.org/10.17826/cumj.1088577 |
| APA | Tosun M, İlgün G, tosun n (2022). Mediating effect of disease severity on the relationship between smoking status and quality of life in psoriasis patients. Cukurova Medical Journal, 47(2), 792 - 799. 10.17826/cumj.1088577 |
| Chicago | Tosun Mustafa,İlgün Gülnur,tosun nurperihan Mediating effect of disease severity on the relationship between smoking status and quality of life in psoriasis patients. Cukurova Medical Journal 47, no.2 (2022): 792 - 799. 10.17826/cumj.1088577 |
| MLA | Tosun Mustafa,İlgün Gülnur,tosun nurperihan Mediating effect of disease severity on the relationship between smoking status and quality of life in psoriasis patients. Cukurova Medical Journal, vol.47, no.2, 2022, ss.792 - 799. 10.17826/cumj.1088577 |
| AMA | Tosun M,İlgün G,tosun n Mediating effect of disease severity on the relationship between smoking status and quality of life in psoriasis patients. Cukurova Medical Journal. 2022; 47(2): 792 - 799. 10.17826/cumj.1088577 |
| Vancouver | Tosun M,İlgün G,tosun n Mediating effect of disease severity on the relationship between smoking status and quality of life in psoriasis patients. Cukurova Medical Journal. 2022; 47(2): 792 - 799. 10.17826/cumj.1088577 |
| IEEE | Tosun M,İlgün G,tosun n "Mediating effect of disease severity on the relationship between smoking status and quality of life in psoriasis patients." Cukurova Medical Journal, 47, ss.792 - 799, 2022. 10.17826/cumj.1088577 |
| ISNAD | Tosun, Mustafa vd. "Mediating effect of disease severity on the relationship between smoking status and quality of life in psoriasis patients". Cukurova Medical Journal 47/2 (2022), 792-799. https://doi.org/10.17826/cumj.1088577 |
