Obstrüktif uyku apne sendromu, endotel disfonksiyonu ve koroner ateroskleroz

DURSUNOĞLU, Dursun; DURSUNOGLU, NESE

Obstrüktif uyku apne sendromu, endotel disfonksiyonu ve koroner ateroskleroz

Neşe DURSUNOĞLU, (Pamukkale Üniversitesi, Tıp Fakültesi, Göğüs Hastalıkları Anabilim Dalı, Denizli, Türkiye)

Dursun DURSUNOĞLU (Pamukkale Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Denizli, Türkiye)

Tüberküloz ve Toraks

4 0

Yıl: 2005 Cilt: 53 Sayı: 3 Sayfa Aralığı: 299 - 306 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Obstrüktif uyku apne sendromu, endotel disfonksiyonu ve koroner ateroskleroz

Öz:

Obstrüktif uyku apne sendromu (OUAS)’nda ardı sıra gelen apne atakları sempatik sistem aktivitesinde artışa, oksidatif strese, intratorasik basınç dalgalanmalarına, sistemik kan basıncında ani sıçramalara, hipoksi ve hiperkapniye yol açmaktadır. Hipertansiyon, diyabet, obezite, koroner arter hastalıkları, inme ve kalp yetersizliği gibi fizyopatolojisinde endotel disfonksiyonun önemli rol oynadığı hastalıklar ile OUAS’ın birlikteliği sıktır. OUAS’da hipoksi sonucu artmış sempatik sistem aktivitesinin yanı sıra, gelişen endotel disfonksiyonunun da vasküler komplikasyonlarda rol oynadığı düşünülmektedir. Sağlıklı kişilerle karşılaştırıldığında, OUAS’lı hastalarda endotel fonksiyonunun bozulduğu ve sendromun şiddeti ile endotel disfonksiyonu arasında anlamlı bir ilişkinin olduğu gösterilmiştir. Bu derlemede OUAS ile endotel disfonksiyonu ilişkisi gözden geçirilmiştir.

Anahtar Kelime: Uyku apne, tıkayıcı Endotel Uyku apne sendromları Ateroskleroz

Konular: Solunum Sistemi Kulak, Burun, Boğaz

Obstructive sleep apnea syndrome, endothelial dysfunction and coronary atherosclerosis

Öz:

In obstructive sleep apnea syndrome (OSAS), repetitive episodes of apnea cause increased sympathetic nerve activity, increased surges in arterial blood pressure, swings in intrathoracic pressure, oxidative stress, hypoxia and hypercapnia. Theassociation of OSAS with some diseases, having endothelial dysfunction in their physiopathology, such as hypertension,diabetes mellitus, obesity, coronary artery diseases, stroke and heart failure is common. Increased sympathetic nerve activity and also endothelial dysfunction which are the results of hypoxia, have important roles in vascular complications of OSAS. When compared with healthy population, an important endothelial dysfunction in OSAS patients and relationship between OSAS severity and endothelial dysfunction have been shown. In this review, the relationship between OSAS and endothelial dysfunction was overviewed.

Anahtar Kelime: Sleep Apnea, Obstructive Endothelium Sleep Apnea Syndromes Atherosclerosis

Konular: Solunum Sistemi Kulak, Burun, Boğaz

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Bibliyografik

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APA	DURSUNOGLU N, DURSUNOĞLU D (2005). Obstrüktif uyku apne sendromu, endotel disfonksiyonu ve koroner ateroskleroz. , 299 - 306.
Chicago	DURSUNOGLU NESE,DURSUNOĞLU Dursun Obstrüktif uyku apne sendromu, endotel disfonksiyonu ve koroner ateroskleroz. (2005): 299 - 306.
MLA	DURSUNOGLU NESE,DURSUNOĞLU Dursun Obstrüktif uyku apne sendromu, endotel disfonksiyonu ve koroner ateroskleroz. , 2005, ss.299 - 306.
AMA	DURSUNOGLU N,DURSUNOĞLU D Obstrüktif uyku apne sendromu, endotel disfonksiyonu ve koroner ateroskleroz. . 2005; 299 - 306.
Vancouver	DURSUNOGLU N,DURSUNOĞLU D Obstrüktif uyku apne sendromu, endotel disfonksiyonu ve koroner ateroskleroz. . 2005; 299 - 306.
IEEE	DURSUNOGLU N,DURSUNOĞLU D "Obstrüktif uyku apne sendromu, endotel disfonksiyonu ve koroner ateroskleroz." , ss.299 - 306, 2005.
ISNAD	DURSUNOGLU, NESE - DURSUNOĞLU, Dursun. "Obstrüktif uyku apne sendromu, endotel disfonksiyonu ve koroner ateroskleroz". (2005), 299-306.

APA	DURSUNOGLU N, DURSUNOĞLU D (2005). Obstrüktif uyku apne sendromu, endotel disfonksiyonu ve koroner ateroskleroz. Tüberküloz ve Toraks, 53(3), 299 - 306.
Chicago	DURSUNOGLU NESE,DURSUNOĞLU Dursun Obstrüktif uyku apne sendromu, endotel disfonksiyonu ve koroner ateroskleroz. Tüberküloz ve Toraks 53, no.3 (2005): 299 - 306.
MLA	DURSUNOGLU NESE,DURSUNOĞLU Dursun Obstrüktif uyku apne sendromu, endotel disfonksiyonu ve koroner ateroskleroz. Tüberküloz ve Toraks, vol.53, no.3, 2005, ss.299 - 306.
AMA	DURSUNOGLU N,DURSUNOĞLU D Obstrüktif uyku apne sendromu, endotel disfonksiyonu ve koroner ateroskleroz. Tüberküloz ve Toraks. 2005; 53(3): 299 - 306.
Vancouver	DURSUNOGLU N,DURSUNOĞLU D Obstrüktif uyku apne sendromu, endotel disfonksiyonu ve koroner ateroskleroz. Tüberküloz ve Toraks. 2005; 53(3): 299 - 306.
IEEE	DURSUNOGLU N,DURSUNOĞLU D "Obstrüktif uyku apne sendromu, endotel disfonksiyonu ve koroner ateroskleroz." Tüberküloz ve Toraks, 53, ss.299 - 306, 2005.
ISNAD	DURSUNOGLU, NESE - DURSUNOĞLU, Dursun. "Obstrüktif uyku apne sendromu, endotel disfonksiyonu ve koroner ateroskleroz". Tüberküloz ve Toraks 53/3 (2005), 299-306.