TY  - JOUR
TI  - Long-Term Effects of Nusinersen Combined Physiotherapy in Spinal
Muscular Atrophy Type 1: A Case Study
AB  - Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disorder that is characterized by
generalized muscle weakness. Any study does not exist showing the results of Nusinersen and physiotherapy
in SMA type 1. Our case was diagnosed with SMA type 1 at the age of 3 months. At 8 months of age, Nusinersen
treatment and physiotherapy were started. The motor skills were evaluated with CHOP-Intend and Hammersmith
Infant Neurological Examinations-2 (HINE-2) before physiotherapy and Nusinersen treatments, and also applied
before each dose of Nusinersen during 22 months. An increase of 14 and 13 points in CHOP-Intend and HINE-2
were shown from baseline to the last visit, respectively. This report revealed the improvement of motor functions
of a child with SMA type 1 by the combination of physiotherapy and Nusinersen. Our study may encourage
physiotherapists and physicians to long-term use of a combination of these two therapies for the aim of motor
improvement in this neuromuscular disease.
AU  - Bulut, Numan
AU  - Uğur, Fatma
AU  - Yılmaz, Öznur
AU  - Karaduman, A. Ayşe
AU  - Aydın Yağcıoğlu, Güllü
AU  - ALEMDAROĞLU-GÜRBÜZ, İpek
DO  - 10.4274/buchd.galenos.2021.83713
PY  - 2022
JO  - İzmir Dr. Behçet Uz Çocuk Hastanesi Dergisi
VL  - 12
IS  - 1
SN  - 2146-2372
SP  - 91
EP  - 96
DB  - TRDizin
UR  - http://search/yayin/detay/524749
ER  -