TY  - JOUR
TI  - Characteristics that distinguish leiomyoma variants from the
ordinary leiomyomas and recurrence risk
AB  - Aims: To evaluate the clinical characteristics that distinguish the leiomyoma variants from the
ordinary ones, as well as the recurrence risk and patterns of these tumors.
Methods: This retrospective, case-control study included women diagnosed with uterine
leiomyoma between 2009 and 2019 at a tertiary referral center in Turkey. The clinical
characteristics of patients diagnosed with cellular leiomyoma (CL), leiomyoma with bizarre
nuclei (LBN), mitotically active leiomyoma (MAL), and ordinary leiomyoma (OL) were examined.
Disease recurrence and patterns of variants were evaluated.
Results: Among the 1,581 women with uterine leiomyoma, the incidence of CL, LBN, and MAL
were 2.9%, 1.2%, and 1.3%, respectively. The occurrence for a single mass (63% in CL, 78.9% in
LBN, 61.9% in MAL, 38.8% in OL; p=0.001) was more common, and the diagnosis of intramural
leiomyoma (67.4% in CL, 73.7% in LBN, 71.4% in MAL, 90.8% in OL; p=0.002) was less frequent
in the leiomyoma variant groups compared with the OL group. Recurrent leiomyosarcoma was
observed in one woman with MAL.
Conclusions: This study showed that single mass rate was higher and intramural leiomyoma
rate was lower in leiomyoma variants than in ordinary variants. Although rare, leiomyoma
variants carry a risk of malignant recurrence after hysterectomy, suggesting the need for longterm follow-up.
AU  - Karakaya, Jale
AU  - Dağdeviren, Gülşah
AU  - Yılmaz Ergani, Seval
AU  - Tapisiz, Omer
AU  - Kiykac Altinbas, Sadiman
AU  - AKPINAR, FUNDA
AU  - KINAY, TUGBA
AU  - KAYIKCIOGLU, FULYA
AU  - Guler Mesci, Cigdem
DO  - 10.4274/gulhane.galenos.2021.1315
PY  - 2022
JO  - Gülhane Tıp Dergisi
VL  - 64
IS  - 1
SN  - 1302-0471
SP  - 6
EP  - 11
DB  - TRDizin
UR  - http://search/yayin/detay/525024
ER  -