TY  - JOUR
TI  - Assessment of cardiac autonomic parameters in patients
with uncomplicated familial Mediterranean fever
AB  - Aims: Cardiac dysautonomia and arrhythmias can occur in chronic inflammatory conditions
such as familial Mediterranean fever (FMF). The aim of this study was to evaluate the cardiac
autonomic functions in patients with FMF.
Methods: This was a retrospective case-control study. Electrocardiography (ECG) and 24-hour
Holter ECG recordings were obtained from the medical records. T-peak to T-end intervals
(Tp-e) and Tp-e/corrected QT (QTc) ratio were calculated on ECG. Heart rate variability (HRV)
parameters and heart rate turbulence (HRT) parameters including turbulence onset (TO) and
turbulence slope (TS) were evaluated using the 24-hour Holter ECG. All subjects were divided
into three groups according to HRT parameters (HRT-0: normal TO and TS; HRT-1: abnormal TS
or TO; and HRT-2: abnormal TO and TS).
Results: The study included 115 individuals (age, years, mean±standard deviation: 34.5±9.6
years, 57% female, 61 FMF patients and 54 controls). Patients with FMF exhibited an increased
ratio of Tp-e, Tp-e/QTc ratio (p<0.001 for both), and impairment in all HRV parameters (p<0.05
for all). Disease duration was correlated with Tp-e (r=0.402, p=0.001), Tp-e/QTc ratio (r=0.382,
p=0.003) and HRV parameters (r>0.264, p<0.05 for all). Of patients with FMF, 32 (52.5%) were in
the HRT-1 group, and 9 (14.8%) were in the HRT-2 group. Patients using anakinra showed more
impairment in the HRV parameters (p<0.05 for all) and Tp-e/QTc ratio (p=0.041) compared to
patients who were not on anakinra.
Conclusions: This study showed cardiac autonomic system impairments in patients with FMF
without complications, which correlated with the disease duration.
AU  - Candemir, Mustafa
AU  - Sezenöz, Burak
AU  - Candemir, Burcu
AU  - NURKOÇ, SERDAR GÖKHAN
DO  - 10.4274/gulhane.galenos.2021.25338
PY  - 2022
JO  - Gülhane Tıp Dergisi
VL  - 64
IS  - 1
SN  - 1302-0471
SP  - 32
EP  - 39
DB  - TRDizin
UR  - http://search/yayin/detay/525031
ER  -