TY  - JOUR
TI  - Restless legs syndrome in migraine patients at an outpatient
clinic
AB  - Aims: The prevalence of Restless legs syndrome (RLS) in migraine patients is estimated to be
8.7-39.0%. In this study, we set out to compare the frequency of RLS in patients diagnosed with
migraine with headache free participants.
Methods: We included 201 patients with migraine with or without aura and age and gendermatched 102 headache free group from outpatient setting in this cross-sectional study.
None of the migraine patients were receiving prophylactic medications that could affect
dopamine metabolism. Patients with comorbidities such as kidney disease, Parkinson’s disease,
rheumatoid arthritis, and polyneuropathy were excluded from this study. The headache free
participants had no neurological or systemic disease, no addiction/and no medical treatment.
The frequency and severity (with RLS Rating Scale) of RLS was examined in two groups.
Results: 40.3% (n=81) of the migraine patients met the diagnostic criteria for RLS than the
headaches-free participants (15.7%, n=16) (p<0.001). The RLS (+) and RLS (-) migraine groups
were similar in terms of age, gender, number of attacks per month, presence of aura, smoking,
and family history for RLS. Disease duration was longer in the migraine patients with RLS and
RLS severity was higher in patients with longer disease duration (p<0.001 and p=0.05). Five of
six patients with hypertension and migraine patients had RLS (vs. 76 of 195 for patients without
hypertension, p=0.04). Logistic regression analysis showed a significant association only
between the disease duration and the presence of RLS [Odds ratio: 13.25, (95% confidence
interval: 5.62-31.24), p=0.001].
Conclusions: This study found almost three times higher frequency of RLS in patients with
migraine. RLS symptoms should be questioned during the management of patients with a
migraine diagnosis, particularly in long-standing disease.
AU  - Akbostanci, Muhittin Cenk
AU  - Sarilar, Ayse Çağlar
AU  - KARAHAN, NESRİN
AU  - arica polat, busra sumeyye
DO  - 10.4274/gulhane.galenos.2021.17363
PY  - 2022
JO  - Gülhane Tıp Dergisi
VL  - 64
IS  - 1
SN  - 1302-0471
SP  - 84
EP  - 88
DB  - TRDizin
UR  - http://search/yayin/detay/525145
ER  -