TY  - JOUR
TI  - Detection of Ibuprofen Levels by High Performance
Liquid Chromatography After Phonophoresis in the
Tissues of Patients with Knee Osteoarthritis:
A Controlled Preliminary Study
AB  - Objective: This study is aimed to detect the drug concentration in
articular tissues after phonophoresis application in patients with knee osteoarthritis who were planned to undergo total knee arthroplasty. Material and
Methods: Seventeen patients with grade 4 knee OA were allocated to 6 groups
according to ultrasound parameters and three sessions of ibuprofen phonophoresis were applied before surgery. Six groups were divided into as follows: Group
1; 5 minutes, frequency 0 MHz, power 0 W/cm2
, continuous mode; Group 2; 5
minutes, frequency 1 MHz, power 1 W/cm2
, continuous mode; Group 3; 5 minutes, frequency 1 MHz, power 1.5 W/cm2
, continuous mode; Group 4; 5 minutes,
frequency 1 MHz, power 1.5 W/cm2
, pulse mode; Group 5; 8 minutes, frequency
1 MHz, power 1.5 W/cm2
, continuous mode; Group 6; 5 minutes, frequency 1
MHz, power 2 W/cm2
, continuous mode. Bone, synovial fluid and synovial tissue samples were obtained from patients during the surgery. A high-performance
liquid chromatographic method was used for the determination of ibuprofen levels from isolated human synovial fluid, synovial tissue and bone. Results: Ibuprofen was detected to the articular tissues of patients. The highest concentrations of
ibuprofen in synovial fluid were detected in Group 3 and 5. The highest concentrations in bone were obtained in Group 2 and in synovial tissue were obtained
in Group 2 and Group 3. Conclusion: Optimal penetration of ibuprofen to articular tissues was obtained with 1 MHz and 1-1.5 W/cm2
, and continuous ultrasound mode. Phonophoresis is seemed as an effective treatment modality in
patients with OA.
AU  - giray, sultan
AU  - KOZANOĞLU, ERKAN
AU  - Kelle, Bayram
AU  - TEKIN, MUSTAFA
AU  - deveci, mehmet ali
AU  - Turk, Murat
DO  - 10.31609/jpmrs.2021-86584
PY  - 2022
JO  - Fiziksel Tıp ve Rehabilitasyon Bilimleri Dergisi
VL  - 25
IS  - 2
SN  - 1309-3843
SP  - 205
EP  - 212
DB  - TRDizin
UR  - http://search/yayin/detay/525225
ER  -