Predictive Factors for Muscle Weakness in Rheumatoid Arthritis
Yıl: 2022 Cilt: 25 Sayı: 2 Sayfa Aralığı: 248 - 253 Metin Dili: İngilizce DOI: 10.31609/jpmrs.2021-87049 İndeks Tarihi: 26-06-2022
Predictive Factors for Muscle Weakness in Rheumatoid Arthritis
Öz: Objective: We aimed to determine muscle strength in patients with rheumatoid arthritis (RA) and several factors including structural
joint damage that may affect decrease in muscle strength. The relations between muscle strength and quality of life and functional disability were examined. Material and Methods: Seventy five RA patients and 51 controls
were involved. Demographic characteristics, body mass index, waist circumference, 25-hydroxy vitamin D, and patient global assessments of disease activity (PGA) were documented. Disease Activity Score-28 (DAS28),
Visual Analog Scale-Pain (VAS-pain), Health Assessment Questionnaire
(HAQ) and the Rheumatoid Arthritis Quality of Life Questionnaire
(RAQoL) were calculated. Radiographs of the hands were evaluated by van
der Heijde modified Sharp score (vdHSS). Grip strength of both hands was
measured by Jamar dynamometer. Results: Demographics (age, gender)
were not different between RA patients and control group. Grip strength of
patients with RA (22.79±18.58) was lower than control group (26.00±11.25,
p=0.04). There was a significant correlation with grip strength and disease
duration, tender joint count, VAS-pain, PGA, DAS28, HAQ, RAQoL, erosion and narrowing score (p<0.05). DAS28 and erosion score were associated
with grip strength in multivariate analyses p<0.05). Conclusion: This study
showed that RA obtains decreased muscle strength, impaired function and
quality of life. Joint space narrowing and disease activity are the main parameters that affect muscle strength.
Anahtar Kelime: Romatoid Artritte Kas Güçsüzlüğü İçin Öngördürücü Faktörler
Öz: Amaç: Romatoid artritli (RA) hastalarda, kas kuvvetini değerlendirmeyi ve kas kuvvetindeki azalmayı etkileyebilecek yapısal eklem hasarı
dâhil çeşitli faktörleri belirlemeyi amaçladık. Bu çalışmada, kas gücü ile
yaşam kalitesi ve fonksiyonel yetersizlik arasındaki ilişki incelenmiştir.
Gereç ve Yöntemler: Yetmiş beş RA hastası ve 51 kontrol alındı. Demografik özellikler, beden kitle indeksi, bel çevresi, 25-hidroksi vitamin D,
hastanın hastalık aktivitesinin küresel değerlendirmesi [patient global assessments of disease activity (PGA)] kaydedildi. Hastalık Aktivite Skoru-28
[Disease Activity Score-28 (DAS28)], Görsel Analog Skala [Visual Analog Scale (VAS)]-ağrı Sağlık Değerlendirme Anketi [Health Assessment
Questionnaire (HAQ)] ve Romatoid Artrit Yaşam Kalitesi Anketi [Rheumatoid Arthritis Quality of Life Questionnaire (RAQoL)] hesaplandı. El
radyografileri van der Heijde modifiye Sharp skoru [van der Heijde modified Sharp score (vdHSS)] ile değerlendirildi. Jamar dinamometre ile her
iki elin kavrama gücü ölçüldü. Bulgular: Demografik özellikler (yaş, cinsiyet) RA hastaları ve kontrol grubu arasında farklı değildi. RA’lı hastaların kavrama gücü (22,79±18,58) kontrol grubundan düşüktü (26,00±11,25;
p=0,04). Kavrama gücü ile hastalık süresi, “tender joint count”, VAS-ağrı,
PGA, DAS28, HAQ, RAQoL, erozyon ve daralma skoru arasında anlamlı
korelasyon vardı (p<0,05). Çok değişkenli analizlerde DAS28 ve erozyon
skoru kavrama gücü ile ilişkili bulundu (p<0,05). Sonuç: Bu çalışma,
RA’nın kas gücünü azalttığını ve fonksiyonel yetersizliğe ve yaşam kalitesinde bozulmaya neden olduğunu göstermiştir. Eklem aralığı ve hastalık aktivitesi kas gücünü etkileyen ana parametrelerdir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- 1. Księżopolska-Orłowska K, Sadura-Sieklucka T, Kasprzak K, et al. The beneficial effects of rehabilitation on hand function in patients with rheumatoid arthritis. Reumatologia. 2016;54: 285-90. [Crossref] [PubMed] [PMC]
- 2. Brooks JM, Titus AJ, Bruce ML, et al. Depression and Handgrip Strength Among U.S. Adults Aged 60 Years and Older from NHANES 2011-2014. J Nutr Health Aging. 2018;22:938-43. [Crossref] [PubMed] [PMC]
- 3. Riviati N, Setiati S, Laksmi PW, et al. Factors related with handgrip strength in elderly patients. Acta Med Indones. 2017;49:215-9. [PubMed]
- 4. Moreira VG, Perez M, Lourenço RA. Prevalence of sarcopenia and its associated factors: the impact of muscle mass, gait speed, and handgrip strength reference values on reported frequencies. Clinics (Sao Paulo). 2019;74:e477. [Crossref] [PubMed] [PMC]
- 5. Summers GD, Metsios GS, Stavropoulos-Kalinoglou A, et al. Rheumatoid cachexia and cardiovascular disease. Nat Rev Rheumatol. 2010;6:445-51. [Crossref] [PubMed]
- 6. Uutela TI, Kautiainen HJ, Häkkinen AH. Decreasing muscle performance associated with increasing disease activity in patients with rheumatoid arthritis. PLoS One. 2018;13: e0194917. [Crossref] [PubMed] [PMC]
- 7. Santillán-Díaz C, Ramírez-Sánchez N, EspinosaMorales R, et al. Prevalence of rheumatoid cachexia assessed by bioelectrical impedance vector analysis and its relation with physical function. Clin Rheumatol. 2018;37:607-14. [Crossref] [PubMed]
- 8. da Rocha OM, de Almeida Peduti Batista A, Maestá N, et al. Sarcopenia in rheumatoid cachexia: definition, mechanisms, clinical consequences and potential therapies. Revista Brasileira de Reumatologia. 2009;49:288-301. [Crossref]
- 9. Baker JF, Von Feldt J, Mostoufi-Moab S, et al. Deficits in muscle mass, muscle density, and modified associations with fat in rheumatoid arthritis. Arthritis Care Res (Hoboken). 2014;66:1612-8. [Crossref] [PubMed] [PMC]
- 10. Sokka T, Häkkinen A, Kautiainen H, et al; QUESTRA Group. Physical inactivity in patients with rheumatoid arthritis: data from twenty-one countries in a cross-sectional, international study. Arthritis Rheum. 2008;59:42-50. [Crossref] [PubMed]
- 11. Yamada T, Steinz MM, Kenne E, et al. Muscle weakness in rheumatoid arthritis: the role of Ca2+ and free radical signaling. EBioMedicine. 2017;23:12-19. [Crossref] [PubMed] [PMC]
- 12. Erol AM, Ceceli E, Uysal Ramadan S, et al. Effect of rheumatoid arthritis on strength, dexterity, coordination and functional status of the hand: the relationship with magnetic resonance imaging findings. Acta Reumatol Port. 2016;41:328-37. English. [PubMed]
- 13. Aletaha D, Neogi T, Silman AJ, et al. 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum. 2010;62:2569-81. [PubMed]
- 14. Prevoo ML, van't Hof MA, Kuper HH, et al. Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum. 1995;38:44-8. [Crossref] [PubMed]
- 15. Price DD, McGrath PA, Rafii A, et al. The validation of visual analogue scales as ratio scale measures for chronic and experimental pain. Pain. 1983;17:45-56. [Crossref] [PubMed]
- 16. Küçükdeveci AA, Sahin H, Ataman S, et al. Issues in cross-cultural validity: example from the adaptation, reliability, and validity testing of a Turkish version of the Stanford Health Assessment Questionnaire. Arthritis Rheum. 2004;51:14-9. [Crossref] [PubMed]
- 17. Kutlay S, Küçükdeveci AA, Gönül D, et al. Adaptation and validation of the Turkish version of the Rheumatoid Arthritis Quality of Life Scale. Rheumatol Int. 2003;23:21-6. [Crossref] [PubMed] 18. van der Heijde D. How to read radiographs according to the Sharp/van der Heijde method. J Rheumatol. 2000;27:261-3. [PubMed]
- 19. Shechtman O, Gestewitz L, Kimble C. Reliability and validity of the DynEx dynamometer. J Hand Ther. 2005;18:339-47. [Crossref] [PubMed]
- 20. Schober P, Boer C, Schwarte LA. Correlation coefficients: appropriate use and interpretation. Anesth Analg. 2018;126:1763-8. [Crossref] [PubMed]
- 21. Taştekin N, Uzunca K, Birtane M ve ark. [The relationship of range of motion and grip strength of the hand with disease activity, hand functions and disability in patients with rheumatoid arthritis]. Romatizma. 2006;21:13-7. [Link]
- 22. Schaap LA, Pluijm SM, Deeg DJ, et al; Health ABC Study. Higher inflammatory marker levels in older persons: associations with 5-year change in muscle mass and muscle strength. J Gerontol A Biol Sci Med Sci. 2009;64:1183-9. [Crossref] [PubMed] [PMC]
- 23. Torii M, Hashimoto M, Hanai A, et al. Prevalence and factors associated with sarcopenia in patients with rheumatoid arthritis. Mod Rheumatol. 2019;29:589- 95. [Crossref] [PubMed]
- 24. Beenakker KG, Ling CH, Meskers CG, et al. Patterns of muscle strength loss with age in the general population and patients with a chronic inflammatory state. Ageing Res Rev. 2010;9:431-6. [Crossref] [PubMed] [PMC]
- 25. Sheehy C, Gaffney K, Mukhtyar C. Standardized grip strength as an outcome measure in early rheumatoid arthritis. Scand J Rheumatol. 2013;42:289-93. [Crossref] [PubMed]
- 26. Uchitomi R, Oyabu M, Kamei Y. Vitamin D and sarcopenia: Potential of Vitamin D supplementation in sarcopenia prevention and treatment. Nutrients. 2020;12:3189. [Crossref] [PubMed] [PMC]
- 27. Özeri Z, Çakıt B, Taşkın S ve ark. [The relationships among functional impairment, disability and articular damage in rheumatoid hand]. FTR Bil Der JPMR Sci. 2008;2:53-8.
- 28. Bodur H, Yilmaz O, Keskin D. Hand disability and related variables in patients with rheumatoid arthritis. Rheumatol Int. 2006;26:541-4. [Crossref] [PubMed]
APA | Onder M, kılıçarslan a, Keskin D, Bodur H (2022). Predictive Factors for Muscle Weakness in Rheumatoid Arthritis . , 248 - 253. 10.31609/jpmrs.2021-87049 |
Chicago | Onder Mustafa Erkut,kılıçarslan ayşegül,Keskin Dilek,Bodur Hatice Predictive Factors for Muscle Weakness in Rheumatoid Arthritis . (2022): 248 - 253. 10.31609/jpmrs.2021-87049 |
MLA | Onder Mustafa Erkut,kılıçarslan ayşegül,Keskin Dilek,Bodur Hatice Predictive Factors for Muscle Weakness in Rheumatoid Arthritis . , 2022, ss.248 - 253. 10.31609/jpmrs.2021-87049 |
AMA | Onder M,kılıçarslan a,Keskin D,Bodur H Predictive Factors for Muscle Weakness in Rheumatoid Arthritis . . 2022; 248 - 253. 10.31609/jpmrs.2021-87049 |
Vancouver | Onder M,kılıçarslan a,Keskin D,Bodur H Predictive Factors for Muscle Weakness in Rheumatoid Arthritis . . 2022; 248 - 253. 10.31609/jpmrs.2021-87049 |
IEEE | Onder M,kılıçarslan a,Keskin D,Bodur H "Predictive Factors for Muscle Weakness in Rheumatoid Arthritis ." , ss.248 - 253, 2022. 10.31609/jpmrs.2021-87049 |
ISNAD | Onder, Mustafa Erkut vd. "Predictive Factors for Muscle Weakness in Rheumatoid Arthritis ". (2022), 248-253. https://doi.org/10.31609/jpmrs.2021-87049 |
APA | Onder M, kılıçarslan a, Keskin D, Bodur H (2022). Predictive Factors for Muscle Weakness in Rheumatoid Arthritis . Fiziksel Tıp ve Rehabilitasyon Bilimleri Dergisi, 25(2), 248 - 253. 10.31609/jpmrs.2021-87049 |
Chicago | Onder Mustafa Erkut,kılıçarslan ayşegül,Keskin Dilek,Bodur Hatice Predictive Factors for Muscle Weakness in Rheumatoid Arthritis . Fiziksel Tıp ve Rehabilitasyon Bilimleri Dergisi 25, no.2 (2022): 248 - 253. 10.31609/jpmrs.2021-87049 |
MLA | Onder Mustafa Erkut,kılıçarslan ayşegül,Keskin Dilek,Bodur Hatice Predictive Factors for Muscle Weakness in Rheumatoid Arthritis . Fiziksel Tıp ve Rehabilitasyon Bilimleri Dergisi, vol.25, no.2, 2022, ss.248 - 253. 10.31609/jpmrs.2021-87049 |
AMA | Onder M,kılıçarslan a,Keskin D,Bodur H Predictive Factors for Muscle Weakness in Rheumatoid Arthritis . Fiziksel Tıp ve Rehabilitasyon Bilimleri Dergisi. 2022; 25(2): 248 - 253. 10.31609/jpmrs.2021-87049 |
Vancouver | Onder M,kılıçarslan a,Keskin D,Bodur H Predictive Factors for Muscle Weakness in Rheumatoid Arthritis . Fiziksel Tıp ve Rehabilitasyon Bilimleri Dergisi. 2022; 25(2): 248 - 253. 10.31609/jpmrs.2021-87049 |
IEEE | Onder M,kılıçarslan a,Keskin D,Bodur H "Predictive Factors for Muscle Weakness in Rheumatoid Arthritis ." Fiziksel Tıp ve Rehabilitasyon Bilimleri Dergisi, 25, ss.248 - 253, 2022. 10.31609/jpmrs.2021-87049 |
ISNAD | Onder, Mustafa Erkut vd. "Predictive Factors for Muscle Weakness in Rheumatoid Arthritis ". Fiziksel Tıp ve Rehabilitasyon Bilimleri Dergisi 25/2 (2022), 248-253. https://doi.org/10.31609/jpmrs.2021-87049 |