TY  - JOUR
TI  - The application of qNMR for the determination of rosuvastatin in tablet form
AB  - In this study, quantative nuclear magnetic resonance (qNMR) method was used to determine the content of rosuvastatin in
tablet. Linearity, range, limit of detection (LOD), limit of quantification (LOQ), accuracy, and precision were determined in validation
study of rosuvastatin. Furthermore, validation study of rosuvastatin was performed with high performance liquid chromatography
(HPLC). Uncertainties of qNMR and HPLC methods were determined using per EURACHEM/CITAC Guide CG 4 (3th edition),
quantifying uncertainty in analytical measurement. qNMR and HPLC methods were linear in the ranges of 0.10 - 5.00 mg/mL and 0.001
- 0.0995 mg/mL, respectively and these lineraties indicate very good linearity performance with regression coefficients (R2 value) above
> 0.99. Moreover, LOD and LOQ values using qNMR method were observed as 0.25 mg/mL and 0.80 mg/mL, respectively. These values
using HPLC method were found as 0.00051 µg/mL and 0.001695 µg/mL, respectively. The strengths and weaknesses of qNMR method
and HPLC method were determined with spectral emphasis on the role of identical reference standards in qualitive and quantitative
analyses. It was found that qNMR method is simple, efficient, reliable, and accurate method. Moreover, qNMR method is an easy, practical, and useful method for the validation and optimization of rosuvastatin in the tablet.
AU  - Dikmen, Gökhan
AU  - Uslu, Okan
DO  - 10.3906/kim-2007-7
PY  - 2021
JO  - Turkish Journal of Chemistry
VL  - 45
IS  - 1
SN  - 1300-0527
SP  - 132
EP  - 142
DB  - TRDizin
UR  - http://search/yayin/detay/525664
ER  -