TY  - JOUR
TI  - Synthesis of hydroxy benzoin/benzil analogs and investigation of their antioxidant,
antimicrobial, enzyme inhibition, and cytotoxic activities
AB  - In this study, hydroxy benzoin (1-7), benzil (8-14), and benzoin/benzil-O-β-D-glucosides (15-25) were synthesized to
investigate their biological activities. An efficient method for synthesizing hydroxy benzoin compounds (1-7) was prepared from four
different benzaldehydes using an ultrasonic bath. Then, antioxidant (FRAP, CUPRAC, and DPPH), antimicrobial (3 Gram (-), 4/6 Gram
(+), one tuberculosis and one fungus), and enzyme inhibition (acetylcholinesterase, butyrylcholine esterase, tyrosinase, α-amylase, and
α- glucosidase) for the all synthesized compounds (1-25) were evaluated. And also, four most active compounds (4, 12, 18a+b, and 25)
from each group were evaluated to the human cervical cancer cell line (HeLa) and anticancer screening tests against the human retinal
normal cell line (RPE). Compound 4 showed HeLa and RPE cancer cell activities as much as cisplatin. The synthesized compounds were
characterized by spectroscopic methods (NMR, FT-IR, UV, LC-QTOF-MS) and the ACD NMR program’s help.
AU  - aliyazicioglu, rezzan
AU  - YAYLI, Nurettin
AU  - BOZDAL, Gözde
AU  - SELLİTEPE, Hasan Erdinç
AU  - Kahriman, Nuran
AU  - Alpay Karaoğlu, Şengül
AU  - aydin, ali
AU  - Miller-Van Wieren, Leila
AU  - BOZDEVECİ, ARİF
AU  - DOGAN, INCI SELIN
AU  - KANBOLAT, Şeyda
DO  - 10.3906/kim-2012-25
PY  - 2021
JO  - Turkish Journal of Chemistry
VL  - 45
IS  - 3
SN  - 1300-0527
SP  - 788
EP  - 804
DB  - TRDizin
UR  - http://search/yayin/detay/526281
ER  -