Objective: Osteosarcopenia is a relatively new defined syndrome in older people, elucidated as the coexistence of osteoporosis and sarcopenia. As this syndrome is newly defined, the interaction between physical dependence, frailty and mortality in older adults is not clear. To determine whether osteosarcopenia (OSP) has a greater effect on daily living activities, frailty, mortality, comorbidities than osteoporosis (OP) and sarcopenia (SP) alone. Materials and Methods: The study included patients aged 65 and over who underwent bone mineral densitometry (BMD) and bioelectrical impedance tests. According to World Health Organization criteria, the osteoporosis group was included as BMD femoral neck T-score of -2.5 and below. The diagnosis of sarcopenia was done according to the criteria of the, “European Working Group on Sarcopenia of Older People 2018”. Mortality detection was performed using the ‘‘TC Turkey Ministry of Health Public Health Agency of Death Reporting System’’. Comprehensive geriatric assessment, comorbidities and clinical frailty scores of the patients were recorded. Results: The mean age of 306 patients (199 women, 65%) was 76.93±7.03. The prevalence of each category (non-sarcopenic non-osteoporotic, OP, SP and OSP) was 40.8%, 17.0%, 19.0% and 23.2%, respectively. Katz, Lawton-Brody, mini-mental state exam and mini nutritional assessment scores were significantly lower in the OSP group (p=0.014; 0.005; <0.001; <0.001, respectively). The clinical frailty score was highest in OSP, consistent with frailty (p=0.001). Seventy-three (23.8%) of 306 patients died. Mortality was highest in OSP (37%, p=0.014). In the logistic analysis, presence of type 2 diabetes mellitus increased the risk of osteosarcopenia (β: 2.701, p=0.004). Conclusion: Osteosarcopenia maybe associated with physical and cognitive dependence, frailty and mortality in older people. Osteoporosis and sarcopenia should be screened together and preventive measures should be taken before they become serious.