TY  - JOUR
TI  - Serum Calprotectin and Iron Metabolism Biomarker Levels in 
Behçet’s Disease
AB  - Objective: This study aimed to investigate the serum levels of calprotectin, hepcidin, iron, and ferritin in Behçet’s disease (BD).
Materials and Methods: This study included 40 patients with BD who met the diagnostic criteria of the BD International Study Group (1990) 
and 40 healthy control participants. Serum high-sensitive C-reactive protein (hsCRP), hepcidin, calprotectin, ferritin, iron, and unsaturated 
iron-binding capacity (UIBC) levels were determined in all study participants.
Results: Statistically significant difference was found between the groups in respect of calprotectin (p<0.05), UIBC (p<0.05), hsCRP (p<0.05), 
and hemoglobin (p<0.05) levels. No statistically significant differences were determined between the patients and the controls in terms of 
hepcidin, iron, and ferritin levels. Cut-off value of 212.3 pg/mL for calprotectin was determined to identify patients with BD having a sensitivity 
and specificity of 100% and 90%, respectively.
Conclusion: Serum calprotectin may be a useful biomarker in the evaluation of inflammatory status and BD diagnosis. Total iron-binding 
capacity and hemoglobin may be more useful in evaluating iron deficiency anemia in patients with BD.
AU  - KARADAĞ, Ahmet
AU  - DOĞAN, Halef Okan
DO  - 10.4274/tod.galenos.2021.45403
PY  - 2021
JO  - Türk Osteoporoz Dergisi
VL  - 27
IS  - 3
SN  - 2147-2653
SP  - 140
EP  - 144
DB  - TRDizin
UR  - http://search/yayin/detay/527464
ER  -