Determination of characterization, antibacterial and drug release properties of POSSbased film synthesized with sol-gel technique

Ates, Burhan; Yılmaz, ismet; Koytepe, Suleyman; Seckin, Turgay; KARACA AÇARI, İDİL

doi:10.3906/kim-2101-56

Determination of characterization, antibacterial and drug release properties of POSSbased film synthesized with sol-gel technique

İdil KARACA AÇARI, (Malatya Turgut Özal Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomühendislik Bölümü, Malatya, Türkiye)

Süleyman KÖYTEPE, (İnönü Üniversitesi, Fen Fakültesi, Kimya Bölümü, Malatya, Türkiye)

Burhan ATEŞ, (İnönü Üniversitesi, Fen Fakültesi, Kimya Bölümü, Malatya, Türkiye)

İsmet YILMAZ, (İnönü Üniversitesi, Fen Fakültesi, Kimya Bölümü, Malatya, Türkiye)

Turgay SEÇKİN (İnönü Üniversitesi, Fen Fakültesi, Kimya Bölümü, Malatya, Türkiye)

Turkish Journal of Chemistry

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Yıl: 2021 Cilt: 45 Sayı: 6 Sayfa Aralığı: 1774 - 1785 Metin Dili: İngilizce DOI: 10.3906/kim-2101-56 İndeks Tarihi: 01-07-2022

Determination of characterization, antibacterial and drug release properties of POSSbased film synthesized with sol-gel technique

Öz:

In the study, antibacterial film synthesis was aimed using sol-gel technique from POSS structure with various functional groups. For this purpose, antibacterial properties have been acquired by metronidazole to the films to be synthesized. The films obtained were coated on glass surface samples by dip coating method. Antibacterial activities of surface coated glass samples were observed in E.coli and S. aureus bacteria. Metronidazole release studies in the film samples were followed by UV spectrophotometer. It was observed that drug release reached 68.90% at the end of the 24th h. As a result, it is thought that the synthesized film will be a good candidate especially for biomedical surface coating areas.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Pielichowski K, Njuguna J, Janouski B, Pielichawski J. Polyhedral oligomeric silsesquioxane (POSS)-containing nanohybrid polymers. Advances in Polymer Science 2006; 201: 225-296. doi:10.1007/12_077
2. Baney RH, Hoh M, Sakakibara A, Suzuki T. Silsesquioxanes. Chemical Reviews 1995; 95(5): 1409-1430. doi:10.1021/cr00037a012
3. Belot V, Corriu R, Leclerg D, Vioux A. Thermal reactivity of hydrogenosilsesquioxane gels. Chemistry of Materials 1991; 3 (1): 127-131. doi: 10.1021/cm00013a029
4. Seçkin T, Köytepe S, Adıgüzel Hİ. Molecular design of POSS core star polyimides as a route to low-kappa dielectric materials. Materials Chemistry and Physics 2008; 112 (3): 1040-1046. doi: 10.1016/j.matchemphys.2008.07.017
5. Cordes DB, Lickiss PD, Rataboul F. Recent developments in the chemistry of cubic polyhedral oligosilsesquioxanes. Chemical Reviews 2010; 110 (4): 2081-2173. doi: 10.1021/cr900201r
6. Fan H, He J, Yang R. Synthesis, characterization, and termal curing of a novel polyhedral oligomeric octa (propargyl amino phenyl) silsesquioxane. Journal of Applied Polymer Science 2013; 127(1): 463-470. doi: 10.1002/app.37734
7. Kanamori K, Nakanishi K. Controlled pore formation in organotrialkoxy-silane-derived hybrids: from aerogels to hierarchically porous monoliths. Chemical Society Reviews 2011; 40: 754-770. doi: 10.1039/c0cs00068j
8. Kuo SW, Chang FC. POSS related polymer nanocomposites. Progress in Polymer Science 2011; 36 (12): 1649-1696. doi: 10.1016/j. progpolymsci.2011.05.002
9. Shea KJ, Loy DA. Bridged polysilsesquioxanes molecular-engineered hybrid organic-inorganic materials. Chemistry of Materials 2001; 13 (10): 3306-3319. doi: 10.1021/cm011074s
10. Ayandele E, Sarkar B, Alexandridis P. Polyhedral Oligomeric Silsesquioxane (POSS)-containing polymer nanocomposites. Nanomaterials 2012; 2 (4): 445-475. doi: 10.3390/nano2040445
11. Pan M-J, Gorzkowski E, McAlliste K. Dielectric properties of polyhedral oligomeric silsesquioxane (POSS)-based nanocomposites at 77K. Hybrid and Nano-Structured Materials 2011; 18: 082006. doi: 10.1088/1757-899X/18/8/082006
12. Li GZ, Wang HN, Pittman CU. Polyhedral oligomeric silsesquioxane (POSS) polymers and copolymers. Journal of Inorganic and Organometalic Polymers 2001; 11 (3): 123-154. doi: 10.1023/A:1015287910502
13. Li GZ, Yamamato T, Nozaki K, Hikosaka M. Crystallization of ladder like polyphenyl silsesquioxane (PPSQ)/isotactic polystyrene (i-PS) blends. Polymer 2009; 42 (20): 8435-8441. doi: 10.1016/s0032-3861 (01)00326-3
14. Wu J, Mather PT. POSS Polymers: Physical Properties and Biomaterials Applications. Polymer Reviews 2009; 49 (1): 25-63. doi: 10.1080/15583720802656237
15. Punshon G, Vara DS, Sales KM, Kidane AG, Salacinski HJ et al. Interactions between endothelial cells and a poly(carbonate-silsesquioxanebridge-urea) urethane. Biomaterials 2005; 26 (32): 6271-6279. doi: 10.1016/j.biomaterials.2005.03.034
16. Khabnadideh S, Rezael Z, Khalafi NA, Motazedian MH. Synthesis of Metronidazole derivatives as antigiardiasis agents. Daru-Jornal of Faculty of Pharmacy 2007; 15 (1): 17-20. doi: 10.1007/12_077
17. Rediguieri CF, Porta V, Nunes DSG, Nunes TM, Junginger HE et al. Biowaiver monographs for immediate release solid oral dosage forms: metronidazole. Journal of Pharmaceutical Sciences 2011; 100 (5): 1618-1627. doi: org/10.1002/jps.22409
18. Ralph ED, Clarke DA. Inactivation of metronidazole by anaerobic and aerobic bacteria. Antimicrobial Agents and Chemotherapy 1978; 14 (3): 377-383. doi: 10.1128/aac.14.3.377
19. Song S, Won J, Kim J-J, Jang YD, Kang YS et al. Organic-Inorganic hybrid compounds containing polyhedral oligomeric silsesquioxane for conservation of stone heritage. ACS Applied Materials & Interfaces 2009; 1 (2): 393-401. doi: 10.1021/am800105t
20. Karasınskı P. Influence of technological parameters on the properties of sol-gel silica films. Optica Applicata 2005; 35 (1): 117-128.
21. Brinker CJ, Frye GC, Hurd AJ, Ashley CS. Fundamentals of sol-gel dip coating. Thin Solid Films 1991; 201 (1): 97-108. doi: 10.1016/0040- 6090 (91)90158-T
22. Liu M, Kono K, Frechet JM. Water-soluble dendritic unimolecular micelles: Their potential as drug delivery agents. Journal of Controlled Release 2000; 65 (1-2): 121-131 doi: 10.1016/s0168-3659(99)00245-X
23. Baker CN, Stocker SA, Culver DHC. Thomsberry. Comparison of the E test to agar dilution broth microdilution, and agar diffusion susceptibility testing techniques by using a special challenge set of bacteria. Journal of Clinical Microbiology 1991; 29 (3): 533-538. doi: 10.1128/JCM.41.3.1062-1068.2003
24. Obaleye JA, Lawal A. Synthesis, characterization and antifungal studies of some metronidazole complexes. Jornal of Applied Sciences and Environmental Management 2007; 11 (4): 15-18.
25. Jabar A. Synthesis and antibacterial activities of new metronidazole and ımıdazole derivatives. Molecules 2009; 14 (7): 2431-2446. doi: 10.3390/molecules 14072431
26. Gültek A, Seçkin T, Adıgüzel Hİ. Design and characterization of amino and chloro functionalized rhombohedral silsesquioxanes. Turkish Journal of Chemistry 2005; 29 (4): 391-399
27. Karatasios I, Maravelaki-Kalaitzaki P. A biomimetic approach to strengthen and protect construction materials with a novel calciumoxalate-silica nanocomposite. Construction and Building Materials 2014; 62: 8-17. doi: 10.1016/j.conbuildmat.2014.01.079
28. Jiang L, Park-Lee KJ, Clinton RM, Tang Z. Mechanical durability of liquid repellent coatings. Surface and Coatings Technology 2017; 328: 182-191. doi: 10.1016/j.surfcoat.2017.08.007
29. Latthe SS, Gurav AB, Maruti CS, Vhatkar RS. Recent progress in preparation of superhydrophobic surfaces: A review. Journal of Surface Engineered Materials 2012; 2: 76-94. doi: 10.4236/jsemat.2012.22014
30. Li B-C, Chang H, Ren K, Xu J-P. Substrate-mediated delivery of gene complex nanoparticles via polydopamine coating for enhancing competitiveness of endothelial cells. Colloids and Surfaces B: Biointerfaces 2016; 147: 172-179. doi: 10.1016/j.colsurfb.2016.07.063
31. Alon N, Miroshnikov Y, Perkas N, Nissan I. Silver nanoparticles promote neuronal growth. Procedia Engineering 2013; 59: 25-29. doi: 10.1016/j.proeng.2013.05.089
32. Siegel SJ, Kahn JB, Metzger K, Winey KI, Werner K et al. Effects of drug type on the degradation rate of PLGA matrices. European Journal of Pharmaceutics and Biopharmaceutics 2006; 64 (3) 287-293. doi: 10.1016/j.ejpb.2006.06.009
33. Junmahabathien T, Panraksa P, Protiarn P, Hormdee D, Noisombut R et al. Preparation and evaluation of metronidazole-loaded pectin films for potentially targeting a microbial infection associated with periodontal disease. Polymers 2013; 10 (9): 2021. doi: 10.3390/ polym10091021
34. Farshforoush P, Ghanbarzadeh S, Goganian AM, Hamishhehkar H. Novel metronidazole- loaded hydrogel as a gastroretentive drug delivery system. Iranian Polymer Journal 2017; 26 (12): 895-901. doi: 10.1007/s13726-017-0575-4
35. Salehi MA, Akbari M, Jahani-kadosari M. Assessing the loading and release of metronidazole from bacterial cellulose films as a pharmaceutical dressing. Journal of Kashan University of Medical Sciences 2017; 21 (3): 240-246.
36. Rima K, Dima M, Cherine S, Paolo Y. Encapsulation of metronidazole in polycaprolactone microspheres. Journal of Drug Delivery&Therapeutics 2019; 9 (1): 190-194. doi: 10.22270/jddt.vgi1.2306
37. Czarnobaj K. Sol-gel-processed silica/polydimethylsiloxane/calcium xerogels as polymeric matrices for metronidazole delivery system. Polymer Bulletin 2011; 66 (2): 223-237. doi: 10.1007/s00289-010-0332-8
38. Czarnobaj K. The design of nanostructured metronidazole - loaded HPC/Oxide Xerogel composites: influence of the formulation parameters on in vitro characterisation. American Association of Pharmaceutical Scientists Technology 2015; 16 (5): 1160-1168. doi: 10.1208/s12249-015-0310-4
39. Li C, Li X, Tao C, Ren L, Zhao Y et al. Amphiphilic antifogging/anti-ıcing coatings containing POSS-PDMAEMA-b-PSBMA. ACS Applied Materials& Interfaces 2017; 9 (27): 22959-22969. doi: 10.1021/acsami.7b05286
40. Bakhshi R, Darbyshire A, Evans JE, You Z, Lu J. Polymeric coating of surface modified nitinol stent with POSS-nanocomposite polymer. Colloids and Surfaces B: Biointerfaces 2011; 86 (1): 93-105. doi: 10.1016/j.colsurfb.2011.03.024
41. Devaux E, Rochery M, Bourbigot S. Polyurethane/clay and polyurethane/POSS nanocomposites as flame retarded coating for polyester and cotton fabrics. Fire and Materials 2002; 26 (4-5): 149-154. doi: 10.1002/fam.792

APA	KARACA AÇARI İ, Koytepe S, Ates B, Yılmaz i, Seckin T (2021). Determination of characterization, antibacterial and drug release properties of POSSbased film synthesized with sol-gel technique. , 1774 - 1785. 10.3906/kim-2101-56
Chicago	KARACA AÇARI İDİL,Koytepe Suleyman,Ates Burhan,Yılmaz ismet,Seckin Turgay Determination of characterization, antibacterial and drug release properties of POSSbased film synthesized with sol-gel technique. (2021): 1774 - 1785. 10.3906/kim-2101-56
MLA	KARACA AÇARI İDİL,Koytepe Suleyman,Ates Burhan,Yılmaz ismet,Seckin Turgay Determination of characterization, antibacterial and drug release properties of POSSbased film synthesized with sol-gel technique. , 2021, ss.1774 - 1785. 10.3906/kim-2101-56
AMA	KARACA AÇARI İ,Koytepe S,Ates B,Yılmaz i,Seckin T Determination of characterization, antibacterial and drug release properties of POSSbased film synthesized with sol-gel technique. . 2021; 1774 - 1785. 10.3906/kim-2101-56
Vancouver	KARACA AÇARI İ,Koytepe S,Ates B,Yılmaz i,Seckin T Determination of characterization, antibacterial and drug release properties of POSSbased film synthesized with sol-gel technique. . 2021; 1774 - 1785. 10.3906/kim-2101-56
IEEE	KARACA AÇARI İ,Koytepe S,Ates B,Yılmaz i,Seckin T "Determination of characterization, antibacterial and drug release properties of POSSbased film synthesized with sol-gel technique." , ss.1774 - 1785, 2021. 10.3906/kim-2101-56
ISNAD	KARACA AÇARI, İDİL vd. "Determination of characterization, antibacterial and drug release properties of POSSbased film synthesized with sol-gel technique". (2021), 1774-1785. https://doi.org/10.3906/kim-2101-56

APA	KARACA AÇARI İ, Koytepe S, Ates B, Yılmaz i, Seckin T (2021). Determination of characterization, antibacterial and drug release properties of POSSbased film synthesized with sol-gel technique. Turkish Journal of Chemistry, 45(6), 1774 - 1785. 10.3906/kim-2101-56
Chicago	KARACA AÇARI İDİL,Koytepe Suleyman,Ates Burhan,Yılmaz ismet,Seckin Turgay Determination of characterization, antibacterial and drug release properties of POSSbased film synthesized with sol-gel technique. Turkish Journal of Chemistry 45, no.6 (2021): 1774 - 1785. 10.3906/kim-2101-56
MLA	KARACA AÇARI İDİL,Koytepe Suleyman,Ates Burhan,Yılmaz ismet,Seckin Turgay Determination of characterization, antibacterial and drug release properties of POSSbased film synthesized with sol-gel technique. Turkish Journal of Chemistry, vol.45, no.6, 2021, ss.1774 - 1785. 10.3906/kim-2101-56
AMA	KARACA AÇARI İ,Koytepe S,Ates B,Yılmaz i,Seckin T Determination of characterization, antibacterial and drug release properties of POSSbased film synthesized with sol-gel technique. Turkish Journal of Chemistry. 2021; 45(6): 1774 - 1785. 10.3906/kim-2101-56
Vancouver	KARACA AÇARI İ,Koytepe S,Ates B,Yılmaz i,Seckin T Determination of characterization, antibacterial and drug release properties of POSSbased film synthesized with sol-gel technique. Turkish Journal of Chemistry. 2021; 45(6): 1774 - 1785. 10.3906/kim-2101-56
IEEE	KARACA AÇARI İ,Koytepe S,Ates B,Yılmaz i,Seckin T "Determination of characterization, antibacterial and drug release properties of POSSbased film synthesized with sol-gel technique." Turkish Journal of Chemistry, 45, ss.1774 - 1785, 2021. 10.3906/kim-2101-56
ISNAD	KARACA AÇARI, İDİL vd. "Determination of characterization, antibacterial and drug release properties of POSSbased film synthesized with sol-gel technique". Turkish Journal of Chemistry 45/6 (2021), 1774-1785. https://doi.org/10.3906/kim-2101-56