Oxidative stress and neurocognitive function in patients with autogenous and reactive type Obsessive Compulsive Disorder

Evrim ÖZKORUMAK KARAGÜZEL, (Karadeniz Teknik Üniversitesi, Tıp Fakültesi, Psikiyatri Anabilim Dalı, Trabzon, Türkiye)
FİLİZ CİVİL ARSLAN, (Karadeniz Teknik Üniversitesi, Tıp Fakültesi, Psikiyatri Anabilim Dalı, Trabzon, Türkiye)
Selim DEMİR, (Karadeniz Teknik Üniversitesi, Tıp Fakültesi, Psikiyatri Anabilim Dalı, Trabzon, Türkiye)
Demet SAĞLAM AYKUT, (Karadeniz Teknik Üniversitesi, Tıp Fakültesi, Psikiyatri Anabilim Dalı, Trabzon, Türkiye)
Yusuf DEMİRTAŞ, (Karadeniz Teknik Üniversitesi, Tıp Fakültesi, Psikiyatri Anabilim Dalı, Trabzon, Türkiye)
Suleyman Caner KARAHAN (Karadeniz Teknik Üniversitesi, Tıp Fakültesi, Psikiyatri Anabilim Dalı, Trabzon, Türkiye)
Klinik Psikiyatri Dergisi
8 1
Yıl: 2022 Cilt: 25 Sayı: 1 Sayfa Aralığı: 15 - 22 Metin Dili: İngilizce DOI: 10.5505/kpd.2022.37431 İndeks Tarihi: 02-07-2022

Oxidative stress and neurocognitive function in patients with autogenous and reactive type Obsessive Compulsive Disorder

Öz:
Objective: The number of studies investigating oxidative stress levels in OCD subtypes is limited. This study aimed to compared total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index values between OCD subtypes and to determine relationship between oxidative stress and neurocognitive function. Method: T19 autogenous type OCD, 21 reactive type OCD and 42 healthy controls were taken to this study.All patients were rated using the Yale-Brown Obsessive Compulsive Scale, the Metacognition Questionnaire, the Beck Depression Inventory and Beck Anxiety Inventory, the Wisconsin Card Sorting Test, and the Stroop test. Serum TOS and TAS levels were determined. Results: TAS levels were significantly higher in patients with OCD (p=0.018) than in the healthy controls. TAS levels were also significantly higher in patients with RT type OCD than in the healthy controls (p=0.003). In RT OCD, TAS was correlated with the Wisconsin Card Sorting Test – trials to complete the first category (p=0.02) and the Metacognition Questionnaire - need to control thoughts (p=0.02) subscales. Discussion: The study findings indicated an overall oxidative imbalance shift toward the antioxidant side in patients with OCD and RT type OCD. This may be a way of coping with the disease. The correlation between TAS and the Wisconsin Card Sorting Test – trials to complete the first category subscale suggests that the change in serum TAS level may be a condition that for overcoming mental inflexibility. These results should be confirmed by prospective studies.
Anahtar Kelime:

Otojen ve reaktif tip Obsesif Kompulsif Bozukluk’lu hastalarda oksidatif stres ve nörokognitif fonksiyon

Öz:
Amaç: OKB altiplerinde oksidatif stres düzeylerini araştıran çalışma sayısı sınırlıdır. Bu çalışma total oksidatif stres(TOS), total antioksidan düzeyi (TAS) ve oksidatif stres indeksini Obsesif Kompulsif Bozukluk (OKB) altiplerinde karşılaştırmak ve oksidatif stresle nörobilişsel işlevler arasındaki ilişkiyi tespit etmek amacıyla planlanmıştır. Yöntem: Bu çalışmaya19 otojen tip OKB, 21 reaktif tip OKB VE 42 sağlıklı kontrol alınmıştır.Tüm hastalara Yale-Brown Obsesif Kompulsif derecelendirme Ölçeği, Metakognisyon Ölçeği, Beck Depreson Ölçeği ve Beck Anksiyete Ölçeği, Stroop Testi ve Winconsin Kart Eşleme ölçeği uygulanmış ve serum TOS ve TAS düzeylerine bakılmıştır. Bulgular: Serum TAS düzeyi OKB hastalarında sağlıklı kontrollere göre anlamlı yüksek tespit edilmiştir(p=0.018). Serum TAS seviyesi Reaktif Tip OKB'de sağlıklı kontrollere göre anlamlı yüksek bulunmuştur(p=0.003). RT OKB'de serum TAS düzeyi Winkonsin Kart Eşleme Testi-ilk kategoriyi tamamlama için deneme sayısı ve Metakognisyon testi-düşünceleri kontrol etme ihtiyacı alt ölçeği ile korele bulunmuştur(sırasıyla p=0.02 p=0.02 ). Sonuç: Bu çalışma OKB hastalarında ve Reaktif Tip tip OKB hastalarında oksidatif stresin antioksidan yöne doğru bir kaymaya yolaçtığını göstermiştir. Bu değişiklik hastalıkla baş etmede kullanılan bir başa çıkma yolu olabilir. TAS ve Winconson Kart Eşleme testi arasındaki korelasyonun tespit edilmiş olması serum TAS düzeyindeki değişimin zihinsel esnekliğe etki edebilen bir durum olabileceğini düşündürtmektedir. Bu çalışmanın sonuçları ileri çalışmalarla doğrulanmalıdır.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1.Toyokuni S. Reactive oxygen species‐induced molecular damage and its application in pathology. Pathology international. 1999;49(2):91-102.
  • 2. Ng F, Berk M, Dean O, Bush AI. Oxidative stress in psychiatric disorders: evidence base and therapeutic implications. Int J Neuropsychopharmacol. 2008 Sep;11(6):851-76.
  • 3. Maia A, Oliveira J, Lajnef M, Mallet L, Tamouza R, Leboyer M, Oliveira-Maia AJ. Oxidative and nitrosative stress markers in obsessive–compulsive disorder: a systematic review and metaanalysis. Acta Psychiat Scand. 2019;139(5):420-33.
  • 4. Kuelz AK, Hohagen F, Voderholzer U. Neuropsychological performance in obsessive-compulsive disorder: a critical review. Biol Psychol. 2004;65(3):185-236.
  • 5. Lee H-J, Kwon S-M. Two different types of obsession: autogenous obsessions and reactive obsessions. Behav Res Ther. 2003;41(1):11-29.
  • 6. Bragdon LB, Gibb BE, Coles ME. Does neuropsychological performance in OCD relate to different symptoms? A metaanalysis comparing the symmetry and obsessing dimensions. Depress Anxiety. 2018;35(8):761-74.
  • 7. Mecocci P, Boccardi V, Cecchetti R, Bastiani P, Scamosci M, Ruggiero C, Baroni M. A long journey into aging, brain aging, and Alzheimer’s disease following the oxidative stress tracks. Journal of Alzheimer's Disease. 2018;62(3):1319-35.
  • 8. Hajjar I, Hayek SS, Goldstein FC, Martin G, Jones DP, Quyyumi A. Oxidative stress predicts cognitive decline with aging in healthy adults: an observational study. Journal of neuroinflammation. 2018;15(1):17.
  • 9. Goodman WK, Price LH, Rasmussen SA, Mazure C, Fleischmann RL, Hill CL, Heninger GR, Charney DS. The Yale-Brown Obsessive Compulsive Scale. I. Development, use, and reliability. Arch Gen Psychiatry. 1989 Nov;46(11):1006-11.
  • 10. Taylor S. Assessment of Obsessions and Compulsions - Reliability, Validity and Sensitivity to Treatment Effects. Clin Psychol Rev. 1995;15(4):261-96.
  • 11. Beck AT, Steer RA, Brown GK. Beck depression inventory- II. San Antonio. 1996;78(2):490-8.
  • 12. Cartwright-Hatton S, Wells A. Beliefs about worry and intrusions: The Meta-Cognitions Questionnaire and its correlates. J Anxiety Disord. 1997;11(3):279-96.
  • 13. Wells A, Cartwright-Hatton S. A short form of the metacognitions questionnaire: properties of the MCQ-30. Behav ResTher. 2004;42(4):385-96.
  • 14. Tosun A, Irak M. Adaptation, validity, and reliability of the metacognition questionnaire-30 for the Turkish population, and its relationship to anxiety and obsessive-compulsive symptoms. Turk Psikiyatr Derg. 2008;19(1):67-80.
  • 15. Olley A, Malhi G, Sachdev P. Memory and executive functioning in obsessive–compulsive disorder: a selective review. J Affect Disorders. 2007;104(1-3):15-23.
  • 16. Stroop JR. The basis of Ligon's theory. The American Journal of Psychology. 1935.
  • 17. MacLeod CM. Half a century of research on the Stroop effect: an integrative review. Psychol Bull. 1991;109(2):163-203.
  • 18. Mentese U, Dogan OV, Turan I, Usta S, Dogan E, Mentese SO, Demir S, Ozer T, Aykan AC, Alver A. Oxidant-Antioxidant Balance during On-Pump Coronary Artery Bypass Grafting. Sci World J. 2014.
  • 19. Menteşe U, Turan I, Usta S, Demir S, Koral Ö, Öztaş Menteşe S, Çavuşoğlu IG, Karahan SC, Alver A, Doğan OV, Aykan AÇ. Systemic oxidant/antioxidant balance in human abdominal aortic aneurysm. Perfusion-Uk. 2016;31(4):288-94.
  • 20. Yilmaz H, Kostakoğlu U, Demir S, Aksoy F, Menteşe A, Karahan SC, Köksal İ, Alver A, Yilmaz G. Carbonic anhydrase I-II autoantibodies and oxidative status in long-term follow-up of patients with Crimean-Congo haemorrhagic fever. Arch Physiol Biochem. 2018;124(1):69-74.
  • 21. Alici D, Bulbul F, Virit O, Unal A, Altindag A, Alpak G, Alici H, Ermis B, Orkmez M, Taysi S, Savas H. Evaluation of oxidative metabolism and oxidative DNA damage in patients with obsessive–compulsive disorder. Psychiatry and clinical neurosciences. 2016;70(2):109-15.
  • 22. Şimşek Ş, Gençoğlan S, Yüksel T. DNA damage and antioxidants in treatment naïve children with obsessive–compulsive disorder. Psychiat Res. 2016;237:133-7.
  • 23. Behl A, Swami G, Sircar SS, Bhatia MS, Banerjee BD. Relationship of possible stress-related biochemical markers to oxidative/antioxidative status in obsessive-compulsive disorder. Neuropsychobiology. 2010;61(4):210-4.
  • 24. Myers SG, Wells A. Obsessive-compulsive symptoms: the contribution of metacognitions and responsibility. J Anxiety Disord. 2005;19(7):806-17.
  • 25. Clark DA, Purdon CL. The assessment of unwanted intrusive thoughts: A review and critique of the literature. Behav Res Ther. 1995;33(8):967-76.
  • 26. Irak M, Tosun A. Exploring the role of metacognition in obsessive–compulsive and anxiety symptoms. J Anxiety Disord. 2008;22(8):1316-25.
  • 27. Cumurcu BE, Ozyurt H, Etikan I, Demir S, Karlidag R. Total antioxidant capacity and total oxidant status in patients with major depression: Impact of antidepressant treatment. Psychiatry and Clinical Neurosciences. 2009;63(5):639-45.
  • 28. Xie T, Li Q, Luo X, Tian L, Wang Z, Tan S, Chen S, Yang G, An H, Yang F, Tan Y. Plasma total antioxidant status and cognitive impairments in first-episode drug-naïve patients with schizophrenia. Cognitive Neurodynamics. 2019;13(4):357-65.
  • 29. Poyurovsky M. Obsessive-compulsive disorder with schizotypal personality disorder (schizotypal OCD). Obsessive- Compulsive Symptoms in Schizophrenia: Springer; 2015. p. 63- 76.
  • 30. Lee HJ, Kim ZS, Kwon SM. Thought disorder in patients with obsessive‐compulsive disorder. J Clin Psychol. 2005;61(4):401-13.
  • 31. Selek S, Herken H, Bulut M, Ceylan MF, Celik H, Savas HA, Erel O. Oxidative imbalance in obsessive compulsive disorder patients: a total evaluation of oxidant-antioxidant status. Prog Neuropsychopharmacol Biol Psychiatry. 2008 Feb 15;32(2):487- 91.
  • 32. Kuloglu M, Atmaca M, Tezcan E, Gecici O, Tunckol H, Ustundag B. Antioxidant enzyme activities and malondialdehyde levels in patients with obsessive-compulsive disorder. Neuropsychobiology. 2002;46(1):27-32.
  • 33. Aydin PC, Koybasi GP, Sert E, Mete L, Oyekcin DG. Executive functions and memory in autogenous and reactive subtype of obsessive-compulsive disorder patients. Compr Psychiatry. 2014;55(4):904-11.
  • 34. Evola M, Hall A, Wall T, Young A, Grammas P. Oxidative stress impairs learning and memory in apoE knockout mice. Pharmacol Biochem Behav. 2010;96(2):181-6.
  • 35. Kolosova NG, Shcheglova TV, Sergeeva SV, Loskutova LV. Long-term antioxidant supplementation attenuates oxidative stress markers and cognitive deficits in senescent-accelerated OXYS rats. Neurobiol Aging. 2006;27(9):1289-97.
  • 36. Akyol O, Zoroglu SS, Armutcu F, Sahin S, Gurel A. Nitric oxide as a physiopathological factor in neuropsychiatric disorders. In Vivo. 2004;18(3):377-90.
  • 37. Nunomura A, Moreira PI, Castellani RJ, Lee HG, Zhu X, Smith MA, Perry G. Oxidative Damage to RNA in Aging and Neurodegenerative Disorders. Neurotox Res. 2012;22(3):231- 48.
  • 38. Bradbury C, Cassin SE, Rector NA. Obsessive beliefs and neurocognitive flexibility in obsessive–compulsive disorder. Psychiat Res. 2011;187(1-2):160-5.
  • 39. Martínez-Cengotitabengoa M, Mac-Dowell KS, Leza JC, Micó JA, Fernandez M, Echevarría E, Sanjuan J, Elorza J, González-Pinto A. Cognitive impairment is related to oxidative stress and chemokine levels in first psychotic episodes. Schizophr Res. 2012;137(1-3):66-72.
  • 40. Talarowska M, Gałecki P, Maes M, Gardner A, Chamielec M, Orzechowska A, Bobińska K, Kowalczyk E. Malondialdehyde plasma concentration correlates with declarative and working memory in patients with recurrent depressive disorder. Mol Biol Rep. 2012;39(5):5359-66.
  • 41. Aydemir O, Cubukcuoglu Z, Erdin S, Tas C, Onur E, Berk M. Oxidative stress markers, cognitive functions, and psychosocial functioning in bipolar disorder: an empirical cross-sectional study. Rev Bras Psiquiatr. 2014;36(4):293-7.
APA özkorumak e, CİVİL ARSLAN F, Demir S, Saglam Aykut D, Demirtaş Y, KARAHAN S (2022). Oxidative stress and neurocognitive function in patients with autogenous and reactive type Obsessive Compulsive Disorder. , 15 - 22. 10.5505/kpd.2022.37431
Chicago özkorumak evrim,CİVİL ARSLAN FİLİZ,Demir Selim,Saglam Aykut Demet,Demirtaş Yusuf,KARAHAN SÜLEYMAN CANER Oxidative stress and neurocognitive function in patients with autogenous and reactive type Obsessive Compulsive Disorder. (2022): 15 - 22. 10.5505/kpd.2022.37431
MLA özkorumak evrim,CİVİL ARSLAN FİLİZ,Demir Selim,Saglam Aykut Demet,Demirtaş Yusuf,KARAHAN SÜLEYMAN CANER Oxidative stress and neurocognitive function in patients with autogenous and reactive type Obsessive Compulsive Disorder. , 2022, ss.15 - 22. 10.5505/kpd.2022.37431
AMA özkorumak e,CİVİL ARSLAN F,Demir S,Saglam Aykut D,Demirtaş Y,KARAHAN S Oxidative stress and neurocognitive function in patients with autogenous and reactive type Obsessive Compulsive Disorder. . 2022; 15 - 22. 10.5505/kpd.2022.37431
Vancouver özkorumak e,CİVİL ARSLAN F,Demir S,Saglam Aykut D,Demirtaş Y,KARAHAN S Oxidative stress and neurocognitive function in patients with autogenous and reactive type Obsessive Compulsive Disorder. . 2022; 15 - 22. 10.5505/kpd.2022.37431
IEEE özkorumak e,CİVİL ARSLAN F,Demir S,Saglam Aykut D,Demirtaş Y,KARAHAN S "Oxidative stress and neurocognitive function in patients with autogenous and reactive type Obsessive Compulsive Disorder." , ss.15 - 22, 2022. 10.5505/kpd.2022.37431
ISNAD özkorumak, evrim vd. "Oxidative stress and neurocognitive function in patients with autogenous and reactive type Obsessive Compulsive Disorder". (2022), 15-22. https://doi.org/10.5505/kpd.2022.37431
APA özkorumak e, CİVİL ARSLAN F, Demir S, Saglam Aykut D, Demirtaş Y, KARAHAN S (2022). Oxidative stress and neurocognitive function in patients with autogenous and reactive type Obsessive Compulsive Disorder. Klinik Psikiyatri Dergisi, 25(1), 15 - 22. 10.5505/kpd.2022.37431
Chicago özkorumak evrim,CİVİL ARSLAN FİLİZ,Demir Selim,Saglam Aykut Demet,Demirtaş Yusuf,KARAHAN SÜLEYMAN CANER Oxidative stress and neurocognitive function in patients with autogenous and reactive type Obsessive Compulsive Disorder. Klinik Psikiyatri Dergisi 25, no.1 (2022): 15 - 22. 10.5505/kpd.2022.37431
MLA özkorumak evrim,CİVİL ARSLAN FİLİZ,Demir Selim,Saglam Aykut Demet,Demirtaş Yusuf,KARAHAN SÜLEYMAN CANER Oxidative stress and neurocognitive function in patients with autogenous and reactive type Obsessive Compulsive Disorder. Klinik Psikiyatri Dergisi, vol.25, no.1, 2022, ss.15 - 22. 10.5505/kpd.2022.37431
AMA özkorumak e,CİVİL ARSLAN F,Demir S,Saglam Aykut D,Demirtaş Y,KARAHAN S Oxidative stress and neurocognitive function in patients with autogenous and reactive type Obsessive Compulsive Disorder. Klinik Psikiyatri Dergisi. 2022; 25(1): 15 - 22. 10.5505/kpd.2022.37431
Vancouver özkorumak e,CİVİL ARSLAN F,Demir S,Saglam Aykut D,Demirtaş Y,KARAHAN S Oxidative stress and neurocognitive function in patients with autogenous and reactive type Obsessive Compulsive Disorder. Klinik Psikiyatri Dergisi. 2022; 25(1): 15 - 22. 10.5505/kpd.2022.37431
IEEE özkorumak e,CİVİL ARSLAN F,Demir S,Saglam Aykut D,Demirtaş Y,KARAHAN S "Oxidative stress and neurocognitive function in patients with autogenous and reactive type Obsessive Compulsive Disorder." Klinik Psikiyatri Dergisi, 25, ss.15 - 22, 2022. 10.5505/kpd.2022.37431
ISNAD özkorumak, evrim vd. "Oxidative stress and neurocognitive function in patients with autogenous and reactive type Obsessive Compulsive Disorder". Klinik Psikiyatri Dergisi 25/1 (2022), 15-22. https://doi.org/10.5505/kpd.2022.37431
Sayfa Oluşturulma Tarihi
23-04-2024 23:45

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