RELATIONSHIPS BETWEEN PARKINSON’S 
DISEASE DEMENTIA AND 25-HYDROXY 
VITAMIN D AND BRAIN-DERIVED 
NEUROTROPHIC FACTOR LEVELS

Turkoz, Yusuf; ALTINAYAR, SİBEL; Demirtaş, Yasemin; Ekmekyapar, Tuba; AKSUNGUR, ZEYNEP

doi:10.31086/tjgeri.2021.238

RELATIONSHIPS BETWEEN PARKINSON’S DISEASE DEMENTIA AND 25-HYDROXY VITAMIN D AND BRAIN-DERIVED NEUROTROPHIC FACTOR LEVELS

Tuba EKMEKYAPAR, (Malatya Eğitim ve Araştırma Hastanesi, Nöroloji Anabilim Dalı, Malatya, Türkiye)

Yusuf TÜRKÖZ, (İnönü Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Malatya, Türkiye)

Zeynep ERDEMLİ, (Malatya Eğitim ve Araştırma Hastanesi, Biyokimya Anabilim Dalı, Malatya, Türkiye)

Yasemin DEMİRTAŞ, (İnönü Üniversitesi, Tıp Fakültesi, Nöroloji Anabilim Dalı, Malatya, Türkiye)

Sibel ALTINAYAR (İnönü Üniversitesi, Tıp Fakültesi, Nöroloji Anabilim Dalı, Malatya, Türkiye)

Türk Geriatri Dergisi

3 0

Yıl: 2021 Cilt: 24 Sayı: 3 Sayfa Aralığı: 407 - 415 Metin Dili: İngilizce DOI: 10.31086/tjgeri.2021.238 İndeks Tarihi: 03-07-2022

RELATIONSHIPS BETWEEN PARKINSON’S DISEASE DEMENTIA AND 25-HYDROXY VITAMIN D AND BRAIN-DERIVED NEUROTROPHIC FACTOR LEVELS

Öz:

Introduction: Parkinson’s disease dementia is an important condition that worsens the quality of life in approximately 30% of parkinson disease patients. Vitamin D deficiency and brain-derived neurotrophic factor have been implicated in the pathogenesis of alzheimer type dementia, parkinson’s disease, and many neurodegenerative diseases. The aim of this study was to investigate the relationship between cognitive impairment and 25-hydroxy vitamin D and brain-derived neurotrophic factor levels in parkinson’s disease dementia patients. Materials and Method: 25-hydroxy vitamin D and brain-derived neurotrophic factor serum levels were evaluated in patients with parkinson’s disease dementia (n = 63) and healthy controls (n = 33). Brain-derived neurotrophic factor and vitamin D levels were examined using one sample t-tests, and multiple comparisons among independent groups were done using ANOVA post hoc Tukey’s test analysis. Wechsler Memory Scale and MiniMental State Examination were used to evaluate the cognitive functions of the groups. The disease levels of the patients were determined using the Hoehn and Yahr scale and the Unified Parkinson’s Disease Rating Scale. Results: There was a significant negative correlation between the worsening of dementia and vitamin D levels (p = 0.009). However, there were significant negative correlations between the unified parkinson’s disease rating scale daily living activity and Hoehn and Yahr scales and vitamin D levels. No significant relationship was found between brain-derived neurotrophic factor and parkinson’s disease dementia (p = 0.983). Conclusions: Vitamin D deficiency plays a role in cognitive loss in parkinson’s disease dementia. Vitamin D replacement can be used in dementia support treatment.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Ekmekyapar T, Turkoz Y, AKSUNGUR Z, Demirtaş Y, ALTINAYAR S (2021). RELATIONSHIPS BETWEEN PARKINSON’S DISEASE DEMENTIA AND 25-HYDROXY VITAMIN D AND BRAIN-DERIVED NEUROTROPHIC FACTOR LEVELS. , 407 - 415. 10.31086/tjgeri.2021.238
Chicago	Ekmekyapar Tuba,Turkoz Yusuf,AKSUNGUR ZEYNEP,Demirtaş Yasemin,ALTINAYAR SİBEL RELATIONSHIPS BETWEEN PARKINSON’S DISEASE DEMENTIA AND 25-HYDROXY VITAMIN D AND BRAIN-DERIVED NEUROTROPHIC FACTOR LEVELS. (2021): 407 - 415. 10.31086/tjgeri.2021.238
MLA	Ekmekyapar Tuba,Turkoz Yusuf,AKSUNGUR ZEYNEP,Demirtaş Yasemin,ALTINAYAR SİBEL RELATIONSHIPS BETWEEN PARKINSON’S DISEASE DEMENTIA AND 25-HYDROXY VITAMIN D AND BRAIN-DERIVED NEUROTROPHIC FACTOR LEVELS. , 2021, ss.407 - 415. 10.31086/tjgeri.2021.238
AMA	Ekmekyapar T,Turkoz Y,AKSUNGUR Z,Demirtaş Y,ALTINAYAR S RELATIONSHIPS BETWEEN PARKINSON’S DISEASE DEMENTIA AND 25-HYDROXY VITAMIN D AND BRAIN-DERIVED NEUROTROPHIC FACTOR LEVELS. . 2021; 407 - 415. 10.31086/tjgeri.2021.238
Vancouver	Ekmekyapar T,Turkoz Y,AKSUNGUR Z,Demirtaş Y,ALTINAYAR S RELATIONSHIPS BETWEEN PARKINSON’S DISEASE DEMENTIA AND 25-HYDROXY VITAMIN D AND BRAIN-DERIVED NEUROTROPHIC FACTOR LEVELS. . 2021; 407 - 415. 10.31086/tjgeri.2021.238
IEEE	Ekmekyapar T,Turkoz Y,AKSUNGUR Z,Demirtaş Y,ALTINAYAR S "RELATIONSHIPS BETWEEN PARKINSON’S DISEASE DEMENTIA AND 25-HYDROXY VITAMIN D AND BRAIN-DERIVED NEUROTROPHIC FACTOR LEVELS." , ss.407 - 415, 2021. 10.31086/tjgeri.2021.238
ISNAD	Ekmekyapar, Tuba vd. "RELATIONSHIPS BETWEEN PARKINSON’S DISEASE DEMENTIA AND 25-HYDROXY VITAMIN D AND BRAIN-DERIVED NEUROTROPHIC FACTOR LEVELS". (2021), 407-415. https://doi.org/10.31086/tjgeri.2021.238

APA	Ekmekyapar T, Turkoz Y, AKSUNGUR Z, Demirtaş Y, ALTINAYAR S (2021). RELATIONSHIPS BETWEEN PARKINSON’S DISEASE DEMENTIA AND 25-HYDROXY VITAMIN D AND BRAIN-DERIVED NEUROTROPHIC FACTOR LEVELS. Türk Geriatri Dergisi, 24(3), 407 - 415. 10.31086/tjgeri.2021.238
Chicago	Ekmekyapar Tuba,Turkoz Yusuf,AKSUNGUR ZEYNEP,Demirtaş Yasemin,ALTINAYAR SİBEL RELATIONSHIPS BETWEEN PARKINSON’S DISEASE DEMENTIA AND 25-HYDROXY VITAMIN D AND BRAIN-DERIVED NEUROTROPHIC FACTOR LEVELS. Türk Geriatri Dergisi 24, no.3 (2021): 407 - 415. 10.31086/tjgeri.2021.238
MLA	Ekmekyapar Tuba,Turkoz Yusuf,AKSUNGUR ZEYNEP,Demirtaş Yasemin,ALTINAYAR SİBEL RELATIONSHIPS BETWEEN PARKINSON’S DISEASE DEMENTIA AND 25-HYDROXY VITAMIN D AND BRAIN-DERIVED NEUROTROPHIC FACTOR LEVELS. Türk Geriatri Dergisi, vol.24, no.3, 2021, ss.407 - 415. 10.31086/tjgeri.2021.238
AMA	Ekmekyapar T,Turkoz Y,AKSUNGUR Z,Demirtaş Y,ALTINAYAR S RELATIONSHIPS BETWEEN PARKINSON’S DISEASE DEMENTIA AND 25-HYDROXY VITAMIN D AND BRAIN-DERIVED NEUROTROPHIC FACTOR LEVELS. Türk Geriatri Dergisi. 2021; 24(3): 407 - 415. 10.31086/tjgeri.2021.238
Vancouver	Ekmekyapar T,Turkoz Y,AKSUNGUR Z,Demirtaş Y,ALTINAYAR S RELATIONSHIPS BETWEEN PARKINSON’S DISEASE DEMENTIA AND 25-HYDROXY VITAMIN D AND BRAIN-DERIVED NEUROTROPHIC FACTOR LEVELS. Türk Geriatri Dergisi. 2021; 24(3): 407 - 415. 10.31086/tjgeri.2021.238
IEEE	Ekmekyapar T,Turkoz Y,AKSUNGUR Z,Demirtaş Y,ALTINAYAR S "RELATIONSHIPS BETWEEN PARKINSON’S DISEASE DEMENTIA AND 25-HYDROXY VITAMIN D AND BRAIN-DERIVED NEUROTROPHIC FACTOR LEVELS." Türk Geriatri Dergisi, 24, ss.407 - 415, 2021. 10.31086/tjgeri.2021.238
ISNAD	Ekmekyapar, Tuba vd. "RELATIONSHIPS BETWEEN PARKINSON’S DISEASE DEMENTIA AND 25-HYDROXY VITAMIN D AND BRAIN-DERIVED NEUROTROPHIC FACTOR LEVELS". Türk Geriatri Dergisi 24/3 (2021), 407-415. https://doi.org/10.31086/tjgeri.2021.238