TY  - JOUR
TI  - RELATIONSHIPS BETWEEN PARKINSON’S 
DISEASE DEMENTIA AND 25-HYDROXY 
VITAMIN D AND BRAIN-DERIVED 
NEUROTROPHIC FACTOR LEVELS
AB  - Introduction: Parkinson’s disease dementia is an important condition 
that worsens the quality of life in approximately 30% of parkinson disease 
patients. Vitamin D deficiency and brain-derived neurotrophic factor have 
been implicated in the pathogenesis of alzheimer type dementia, parkinson’s 
disease, and many neurodegenerative diseases. The aim of this study was to 
investigate the relationship between cognitive impairment and 25-hydroxy 
vitamin D and brain-derived neurotrophic factor levels in parkinson’s disease 
dementia patients.
Materials and Method: 25-hydroxy vitamin D and brain-derived 
neurotrophic factor serum levels were evaluated in patients with parkinson’s 
disease dementia (n = 63) and healthy controls (n = 33). Brain-derived 
neurotrophic factor and vitamin D levels were examined using one sample 
t-tests, and multiple comparisons among independent groups were done 
using ANOVA post hoc Tukey’s test analysis. Wechsler Memory Scale and MiniMental State Examination were used to evaluate the cognitive functions of the 
groups. The disease levels of the patients were determined using the Hoehn 
and Yahr scale and the Unified Parkinson’s Disease Rating Scale.
Results: There was a significant negative correlation between the 
worsening of dementia and vitamin D levels (p = 0.009). However, there were 
significant negative correlations between the unified parkinson’s disease rating 
scale daily living activity and Hoehn and Yahr scales and vitamin D levels. No 
significant relationship was found between brain-derived neurotrophic factor 
and parkinson’s disease dementia (p = 0.983).
Conclusions: Vitamin D deficiency plays a role in cognitive loss in 
parkinson’s disease dementia. Vitamin D replacement can be used in dementia 
support treatment.
AU  - Turkoz, Yusuf
AU  - ALTINAYAR, SİBEL
AU  - Demirtaş, Yasemin
AU  - Ekmekyapar, Tuba
AU  - AKSUNGUR, ZEYNEP
DO  - 10.31086/tjgeri.2021.238
PY  - 2021
JO  - Türk Geriatri Dergisi
VL  - 24
IS  - 3
SN  - 1304-2947
SP  - 407
EP  - 415
DB  - TRDizin
UR  - http://search/yayin/detay/529320
ER  -