TY  - JOUR
TI  - Identification of microRNAs in the follicular and luteal tissues of Holstein-Friesian cows
AB  - MicroRNAs (miRNAs) regulate many physiological pathways, including development, cell differentiation, immune response
as well as diseases by post-transcriptional processes. However, information is limited regarding the biological roles of miRNAs in the
development of the follicular and luteal tissues in cows. The main aim of the present study was to identify miRNAs that are expressed
in the follicular and luteal tissues of cows. We used a comparative RNA sequencing method to identify miRNA candidates that might
play key roles in the follicular and luteal phases of Holstein cows. Nine miRNAs were expressed at a high ratio: 8 in the follicular tissue
and one in the luteal tissue. Bioinformatics analysis predicted 2479 target genes. RNA sequencing identified several miRNA candidates,
including bta-miR-196a, bta-miR-490, bta-miR-1247-5p, bta-miR-34c, and bta-miR-222. These were associated with pathways like
TGF-beta signaling, gonadotropin-releasing hormone receptor, prolactin signaling, and progesterone-mediated oocyte maturation
associated with the reproductive system. These findings will be beneficial in future comprehensive studies on the miRNAs involved in
regulating the development of follicular and luteal tissues in cows.
AU  - özdemir, selçuk
AU  - ÇOMAKLI, Selim
DO  - 10.3906/vet-2005-80
PY  - 2021
JO  - Turkish Journal of Veterinary and Animal Sciences
VL  - 45
IS  - 3
SN  - 1300-0128
SP  - 508
EP  - 518
DB  - TRDizin
UR  - http://search/yayin/detay/529565
ER  -