TY  - JOUR
TI  - Electroanalytical investigation and voltammetric quantification of antiviral drug
favipiravir in the pharmaceutical formulation and urine sample using a glassy carbon
electrode in anionic surfactant media
AB  - This work describes the electrochemical investigation of a promising antiviral agent, favipiravir (FAV) utilizing a nonmodified glassy carbon (GC) electrode, along with a unique voltammetric approach that can determine FAV with a good degree of accuracy, speed, and cost-effectiveness. Using cyclic voltammetry, the compound demonstrated a single well-defined and an irreversible oxidation peak at approximately +1.12 V (vs. Ag/AgCl) in Britton–Robinson (BR) buffer at pH 10.0. The synergistic effect of anionic surfactant, sodium dodecyl sulfate (SDS) on the adsorption ability of GC electrode remarkably increased the sensitivity of the stripping voltammetric measurements of FAV. Employing square-wave adsorptive stripping voltammetry at +1.17 V (vs. Ag/AgCl) (after 60 s accumulation at open-circuit condition) in BR buffer (pH 10.0) containing 3 × 10–4 M SDS, the linear relationship is found for FAV quantification in the concentration from 1.0 to 100.0 $μg mL^{–1} (6.4 × 10^{–6}–6.4 × 10^{–}4 M)$ with a detection limit of 0.26 $μg mL^{–1} (1.7 × 10^{–6} M)$. The proposed approach was used successfully to determine FAV in pharmaceutical formulations and model human urine samples.
AU  - yardım, yavuz
AU  - Akca, Zeynep
AU  - ÖZOK, Hande İzem
AU  - Şentürk, Zühre
DO  - 10.55730/1300-0527.3375
PY  - 2022
JO  - Turkish Journal of Chemistry
VL  - 46
IS  - 3
SN  - 1300-0527
SP  - 869
EP  - 880
DB  - TRDizin
UR  - http://search/yayin/detay/529599
ER  -