TY  - JOUR
TI  - Prediction of mortality at first admission in COVID-19 pneumonia:
A retrospective cohort study
AB  - The Coronovirus-19 (COVID-19) pandemic that started in Wuhan, China, at the end of 2019 may cause severe acute respiratory syndrome in some patients. We aimed
to investigate the factors that can provide admission mortality prediction in patients with a definite diagnosis of COVID-19. We included patients with radiologically
confirmed COVID-19 pneumonia with any significant comorbidities between February 2020-May 2020. We included 129 patients with a mean age of 58 ±15.3 years (range
16-88), 74 (57.4%) men, and of which 27 (21%) died in hospital. Age, aspartate aminotransferase (AST), gamma-glutamyltranspeptidase (GGT), albumin, international
normalization ratio (INR), C-reactive protein (CRP), ferritin, d-dimer, and leukocyte levels differed between those who survived and died in the hospital. Multivariable
regression showed increased odds of in-hospital death associated with older age (odds ratio 1.09 95% Confidence Interval [CI] (1.021-1.169; p=0.01), and ferritin 1.003
(1.001-1.004; p<0.001) which could help clinicians to identify patients with poor prognosis at an early stage. The area under the receiver operating characteristic curve
was 0.886 (95% CI, 0.811-0.939; p<0.0001) for ferritin and 0.763 (95% CI, 0.673-0.85; p<0.0001) for age in differentiating between survived and died in-hospital patients
with cutoffs >289,1 ng/mL and >51 years, respectively. Elevated ferritin and advanced age significantly predicted mortality at the first admission in COVID-19 infection.
A ferritin cutoff >289 ng/mL had a 100% negative predictive value to differentiate surviving from in-hospital dead patients.
AU  - Senturk, Hakan
AU  - HÜSEYNOV, NURLAN
AU  - Yurtsever, İsmail
AU  - uysal, ömer
AU  - Köker, İbrahim Hakkı
DO  - 10.5455/medscience.2021.07.237
PY  - 2022
JO  - Medicine Science
VL  - 11
IS  - 2
SN  - 2147-0634
SP  - 457
EP  - 461
DB  - TRDizin
UR  - http://search/yayin/detay/529654
ER  -