TY  - JOUR
TI  - The effects of pulsed magnetic field on the key elements responsible for synthesis and
destruction of elastin-collagen in diabetic lung tissue
AB  - Changes in the expression levels of genes responsible for synthesis-destruction of elastin-collagen and the occurrence of lung diseases are in correlation. Although,
diabetes-related complications are important health problems, the mechanism by which diabetes exerts this effect is unclear. On the other hand, although the effect of
pulsed magnetic field (PMF) in lung diseases has been shown, its mechanism of action is unknown. The study aimed to determine the effects of PMF on the key regulator
elements of the synthesis-destruction of elastin-collagen at the transcriptional level. Rats were divided into groups as control, control + PMF 10Hz, diabetes, diabetes +
PMF 10Hz. PMF groups were exposed to 10 Hz PMF for four weeks. In diabetic conditions, ELN, ELANE, and COL1A1 genes were dysregulated at the transcriptional
level as their levels were 14.23±2.56; 7.62±1.37 and 0.24±0.04, respectively. Dysregulated ELN gene expressions were decreased to 6.17±1.97 by PMF application. There
were no meaningful changes in gene expressions in control + PMF 10 Hz groups. The present study shows that ELN, ELANE, and COL1A1 may play a key role at the
transcriptional level in the mechanism of diabetic-lung diseases. In addition, it may be said that “PMF shows its effect by re-regulating the expression level of ELN gene
in diabetic lung tissues”. In future studies, ELN gene-targeted PMF application methods may be developed. Moreover, PMF application might not affect the genes that are
responsible for elastin-collagen synthesis-destruction in healthy lungs when the PMF is applied on different tissues for the treatment of various diseases.
AU  - TOKUŞ, Murat
AU  - cicek, figen
AU  - Ocal, Isil
AU  - GÜNAY, ISMAIL
AU  - TOKGÜN, ONUR
AU  - Coşkun, Çağıl
DO  - 10.5455/medscience.2021.10.332
PY  - 2022
JO  - Medicine Science
VL  - 11
IS  - 2
SN  - 2147-0634
SP  - 586
EP  - 592
DB  - TRDizin
UR  - http://search/yayin/detay/529738
ER  -