The Khans, which are important structures for the safety of the roads as well as meeting the accommodation needs of the caravans, reveal the trade network that spread all over Anatolia, especially in the XIIIth century. Although Khans are sheltered and solid structures, very few of them have reached to the present as many of them lost their function in time. One of these Khans, which had been already dilapidated until the recent years, but was destroyed during the road works, is Çermik Khan, located in the center of Çermik District, which is in 90 km distance from Diyarbakır Province. Çermik Khan, which is in the concentric Khans group, is an Anatolian Seljuk structure dated to the first half of the XIIIth century by taking into account similar plan examples. The building, which occupies a rectangular area close to a square, is divided into two by a wall parallel to the entrance. The part at the east of the wall dividing into the Khan two, which consists of completely closed sections, is arranged as a closed courtyard, iwans and service sections, whilst the part at its west is arranged as a sheltering section. The building, located on a mountainous area and on a road route that hard to use in winter, is located at a crossroad. While the road route leaving from Çermik connects Diyarbakır to Kâhta District and Malatya with a short road, another road connects Diyarbakır to Şanlıurfa via Siverek District. Our aim in this study is to contribute to the determination of road routes by announcing the existence of Çermik Khan on the one hand, and to emphasize the importance of these structures by drawing attention to the buildings that still exist but are in a neglected condition on the other hand.