TY  - JOUR
TI  - Synthesis, molecular modeling, and biological evaluation of novel imatinib derivatives as
anticancer agents
AB  - Different derivatives of imatinib were synthesized by a 3-step reaction method. The structures of the new compounds were characterized by spectroscopic methods. For quantitative evaluation of the biological activity of the compounds, MTT assays were performed, where four BCR-ABL negative leukemic cell lines (Jurkat, Reh, Nalm-6 and Molt-4), one BCR-ABL positive cell line (K562), and one non-leukemic cell line (Hek293T) were incubated with various concentrations of the derivatives. Although imatinib was specifically designed for the BCR-ABL protein, our results showed that it was also effective on BCR-ABL negative cell lines except for Reh cell line. Compound 9 showed lowest I$C_{50}$ values against Nalm-6 cells as 1.639 µM, also the values of Compound 10 for each cell were very close to imatinib. Molecular docking simulations suggest that except for compound 6, the compounds prefer a DFG-out conformation of the ABL kinase domain. Among them, compound 10 has the highest affinity for ABL kinase domain that is close to the affinity of imatinib. The common rings between compound 10 and imatinib adopt exactly the same conformation and same type of interactions in the ATP binding site with the ABL kinase domain. 
AU  - NG, YUK YIN
AU  - Günay, Fulya
AU  - Balta, Sevcan
AU  - Turgut, Zuhal
AU  - Gunkara, Omer Tahir
AU  - Ulucan, Ozlem
DO  - 10.3906/kim-2107-23
PY  - 2022
JO  - Turkish Journal of Chemistry
VL  - 46
IS  - 1
SN  - 1300-0527
SP  - 86
EP  - 102
DB  - TRDizin
UR  - http://search/yayin/detay/529806
ER  -