TY  - JOUR
TI  - Effect of Non-surgical Periodontal 
Treatment on Gingival Crevicular Fluid 
Interleukin-1beta and Interleukin-37 in 
Different Periodontal Diseases
AB  - Objective: Interleukin-37 (IL-37), which is a natural inhibitor of innate immunity, 
is correlated with chronic inflammation and some autoimmune diseases. Proinflammatory cytokines, for example, interleukin-1beta (IL-1β), which plays a key 
part in the periodontium, can induce IL-37. This study aimed to investigate the 
effect of non-surgical periodontal treatment on gingival crevicular fluid (GCF) IL37 and IL-1β levels in generalized aggressive periodontitis (G-AgP) and generalized 
chronic periodontitis (GCP).
Materials and Methods: Thirty-five patients with G-AgP, 30 patients with GCP 
and 30 volunteers with healthy periodontal status (C) were included in this 
research. Patient groups received scaling and root planning with periodontal hand 
instrumentations. Clinical periodontal parameters and GCF samples were collected 
at baseline and at six weeks following SRP. Biomarker levels in GCF were analysed 
by enzyme-linked immunosorbent assay.
Results: Both periodontitis groups exhibited significant improvement in clinical 
parameters (p<0.05). GCF IL-37 levels were significantly higher in G-AgP and GCP 
groups than in the C group at baseline (p<0.05). Following periodontal treatment, 
GCF IL-37 levels were decreased and comparable in all groups. The GCF IL-1β levels 
were significantly higher at baseline in the G-AgP group than those in GCP and C 
groups, and after periodontal therapy, a decrease was detected in GCF IL-1β levels. 
GCF levels of IL-1β were positively correlated with GCF IL-37 levels.
Conclusion: Clinical improvement was found in both periodontitis groups after 
periodontal treatment. IL-1β is a key regulator of periodontal inflammation and 
bone resorption. According to the results of our research, IL-37 may be useful 
marker of determining the clinical health and disease status of patients with 
periodontitis. However, further studies are required to determine the mechanism 
of IL-37 in periodontal inflammation.
AU  - PİRİM GÖRGÜN, EMİNE
AU  - TOKER, HÜLYA
AU  - poyraz, ömer
DO  - 10.4274/meandros.galenos.2021.09821
PY  - 2021
JO  - Meandros Medical And Dental Journal
VL  - 22
IS  - 1
SN  - 2149-9063
SP  - 110
EP  - 118
DB  - TRDizin
UR  - http://search/yayin/detay/530113
ER  -