Synthesis of benzoyl hydrazones having 4-hydroxy-3,5-dimethoxy phenyl ring, their
biological activities, and molecular modeling studies on enzyme inhibition activities

KURSUN AKTAR, BEDRİYE SEDA; Tatar Yılmaz, Gizem; SICAK, Yusuf; oruç-emre, emine elçin

doi:10.3906/kim-2107-7

Synthesis of benzoyl hydrazones having 4-hydroxy-3,5-dimethoxy phenyl ring, their biological activities, and molecular modeling studies on enzyme inhibition activities

Bedriye Seda KURŞUN AKTAR, (Çankırı Karatekin Üniversitesi, Yapraklı Meslek Yüksekokulu, Mülkiyet Koruma ve Güvenlik Bölümü, Çankırı, Türkiye)

Yusuf SICAK, (Muğla Sıtkı Koçman Üniversitesi, Köyceğiz Meslek Yüksekokulu, Bitkisel ve Hayvansal Üretim Bölümü, Muğla, Türkiye)

Gizem TATAR, (Karadeniz Teknik Üniversitesi, Tıp Fakültesi, Biyoistatistik ve Tıp Bilişimi Anabilim Dalı, Trabzon, Türkiye)

Emine ELÇİN EMRE (Gaziantep Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü, Gaziantep, Türkiye)

Turkish Journal of Chemistry

17 0

Yıl: 2022 Cilt: 46 Sayı: 1 Sayfa Aralığı: 236 - 252 Metin Dili: İngilizce DOI: 10.3906/kim-2107-7 İndeks Tarihi: 05-07-2022

Synthesis of benzoyl hydrazones having 4-hydroxy-3,5-dimethoxy phenyl ring, their biological activities, and molecular modeling studies on enzyme inhibition activities

Öz:

Hydrazone compounds have high capacity in terms of antioxidant activity and enzyme inhibition activities such as anticholinesterase, tyrosinase, and urease. In this study, benzoyl hydrazones compounds (7a-7m) were synthesized starting from 3,5-dimethoxy-4-hydroxybenzaldehyde. Antioxidant activity of the synthesized compounds was evaluated. In the β-carotene-linoleic acid and ABTS cation radical scavenging activities, compounds 7j, 7e, and 7m stood out as the most active compounds, respectively. In the anticholinesterase enzyme inhibition activity results, compound 7f exhibited the best activity against AChE and BChE enzymes in the synthesis series. In addition, molecular docking analysis was performed to understand the inhibition mechanism of the synthesized compounds with target enzymes at the atomic level. In the light of biological activity and in silico studies, it has the potential to guide studies for the development of new drugs for Alzheimer disease in the future.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	KURSUN AKTAR B, SICAK Y, Tatar Yılmaz G, oruç-emre e (2022). Synthesis of benzoyl hydrazones having 4-hydroxy-3,5-dimethoxy phenyl ring, their biological activities, and molecular modeling studies on enzyme inhibition activities. , 236 - 252. 10.3906/kim-2107-7
Chicago	KURSUN AKTAR BEDRİYE SEDA,SICAK Yusuf,Tatar Yılmaz Gizem,oruç-emre emine elçin Synthesis of benzoyl hydrazones having 4-hydroxy-3,5-dimethoxy phenyl ring, their biological activities, and molecular modeling studies on enzyme inhibition activities. (2022): 236 - 252. 10.3906/kim-2107-7
MLA	KURSUN AKTAR BEDRİYE SEDA,SICAK Yusuf,Tatar Yılmaz Gizem,oruç-emre emine elçin Synthesis of benzoyl hydrazones having 4-hydroxy-3,5-dimethoxy phenyl ring, their biological activities, and molecular modeling studies on enzyme inhibition activities. , 2022, ss.236 - 252. 10.3906/kim-2107-7
AMA	KURSUN AKTAR B,SICAK Y,Tatar Yılmaz G,oruç-emre e Synthesis of benzoyl hydrazones having 4-hydroxy-3,5-dimethoxy phenyl ring, their biological activities, and molecular modeling studies on enzyme inhibition activities. . 2022; 236 - 252. 10.3906/kim-2107-7
Vancouver	KURSUN AKTAR B,SICAK Y,Tatar Yılmaz G,oruç-emre e Synthesis of benzoyl hydrazones having 4-hydroxy-3,5-dimethoxy phenyl ring, their biological activities, and molecular modeling studies on enzyme inhibition activities. . 2022; 236 - 252. 10.3906/kim-2107-7
IEEE	KURSUN AKTAR B,SICAK Y,Tatar Yılmaz G,oruç-emre e "Synthesis of benzoyl hydrazones having 4-hydroxy-3,5-dimethoxy phenyl ring, their biological activities, and molecular modeling studies on enzyme inhibition activities." , ss.236 - 252, 2022. 10.3906/kim-2107-7
ISNAD	KURSUN AKTAR, BEDRİYE SEDA vd. "Synthesis of benzoyl hydrazones having 4-hydroxy-3,5-dimethoxy phenyl ring, their biological activities, and molecular modeling studies on enzyme inhibition activities". (2022), 236-252. https://doi.org/10.3906/kim-2107-7

APA	KURSUN AKTAR B, SICAK Y, Tatar Yılmaz G, oruç-emre e (2022). Synthesis of benzoyl hydrazones having 4-hydroxy-3,5-dimethoxy phenyl ring, their biological activities, and molecular modeling studies on enzyme inhibition activities. Turkish Journal of Chemistry, 46(1), 236 - 252. 10.3906/kim-2107-7
Chicago	KURSUN AKTAR BEDRİYE SEDA,SICAK Yusuf,Tatar Yılmaz Gizem,oruç-emre emine elçin Synthesis of benzoyl hydrazones having 4-hydroxy-3,5-dimethoxy phenyl ring, their biological activities, and molecular modeling studies on enzyme inhibition activities. Turkish Journal of Chemistry 46, no.1 (2022): 236 - 252. 10.3906/kim-2107-7
MLA	KURSUN AKTAR BEDRİYE SEDA,SICAK Yusuf,Tatar Yılmaz Gizem,oruç-emre emine elçin Synthesis of benzoyl hydrazones having 4-hydroxy-3,5-dimethoxy phenyl ring, their biological activities, and molecular modeling studies on enzyme inhibition activities. Turkish Journal of Chemistry, vol.46, no.1, 2022, ss.236 - 252. 10.3906/kim-2107-7
AMA	KURSUN AKTAR B,SICAK Y,Tatar Yılmaz G,oruç-emre e Synthesis of benzoyl hydrazones having 4-hydroxy-3,5-dimethoxy phenyl ring, their biological activities, and molecular modeling studies on enzyme inhibition activities. Turkish Journal of Chemistry. 2022; 46(1): 236 - 252. 10.3906/kim-2107-7
Vancouver	KURSUN AKTAR B,SICAK Y,Tatar Yılmaz G,oruç-emre e Synthesis of benzoyl hydrazones having 4-hydroxy-3,5-dimethoxy phenyl ring, their biological activities, and molecular modeling studies on enzyme inhibition activities. Turkish Journal of Chemistry. 2022; 46(1): 236 - 252. 10.3906/kim-2107-7
IEEE	KURSUN AKTAR B,SICAK Y,Tatar Yılmaz G,oruç-emre e "Synthesis of benzoyl hydrazones having 4-hydroxy-3,5-dimethoxy phenyl ring, their biological activities, and molecular modeling studies on enzyme inhibition activities." Turkish Journal of Chemistry, 46, ss.236 - 252, 2022. 10.3906/kim-2107-7
ISNAD	KURSUN AKTAR, BEDRİYE SEDA vd. "Synthesis of benzoyl hydrazones having 4-hydroxy-3,5-dimethoxy phenyl ring, their biological activities, and molecular modeling studies on enzyme inhibition activities". Turkish Journal of Chemistry 46/1 (2022), 236-252. https://doi.org/10.3906/kim-2107-7