TY  - JOUR
TI  - The Relationship Between Clinical Outcomes and Calculated Thrombus
Burden Before and After Initial Flow in Patients with ST-Segment
Elevation Myocardial Infarction
AB  - Objective: Primary percutaneous coronary intervention is the standard treatment for ST-segment elevation
myocardial infarction. Although myocardial and epicardial perfusion is usually achieved with primary
percutaneous coronary intervention, infarct-related arterial thrombus burden negatively affects the procedural
success and clinical outcomes of primary percutaneous coronary intervention. Therefore, we aimed
to investigate the association between thrombus burden (calculated before and after initial flow) and clinical
consequences in patients with ST-segment elevation myocardial infarction.
Materials and Methods: This study retrospectively enrolled 1376 patients who had ST-segment elevation myocardial
infarction between May 2012 and November 2015. Patients who had only undergone balloon angioplasty
and emergency coronary artery bypass grafting were not included in the study. Data regarding the initial
clinical and demographic features of the patients were obtained from their hospital records. Thrombus burden
was calculated using baseline and final (after wire inflation or small balloon dilatation) thrombolysis in myocardial
infarction thrombus grades. The endpoints of the study were defined as no-reflow development after primary
percutaneous coronary intervention and 1-year all-cause mortality. Statistical significance was defined as P < .05.
Results: No-reflow was detected in 169 patients (12.3%). The calculated basal thrombus burden was significantly
associated with post-procedural no-reflow (P < .001). No-reflow was also associated with advanced
age (P < .001), longer pain-to-door time (P < .001), and increased blood glucose levels (P = .032). The calculated
final thrombus burden was related to 1-year all-cause mortality (P = .047). One-year all-cause mortality
was also associated with advanced age (P < .001), high Killip scores (P = .003), increased white blood cell
counts (P = .001), and low estimated glomerular filtration rates (P < .001).
Conclusion: Basal thrombus burden was associated with no-reflow, and final thrombus burden was associated
with 1-year all-cause mortality. The calculation of thrombus burden before and after initial flow may
help to predict clinical outcomes.
AU  - GÜNDOĞDU, FUAT
AU  - Karakelleoğlu, Şule
AU  - Şenocak, Hüseyin
AU  - topcu, selim
AU  - AKSAKAL, Emrah
AU  - KOZA, YAVUZER
AU  - Birdal, Oğuzhan
AU  - Tanboga, Ibrahim Halil
DO  - 10.5152/eurasianjmed.2022.21021
PY  - 2022
JO  - Eurasian Journal of Medicine
VL  - 54
IS  - 2
SN  - 1308-8734
SP  - 145
EP  - 149
DB  - TRDizin
UR  - http://search/yayin/detay/530124
ER  -