The Importance of Heat Shock-Related 70-kDa Protein 2 Expression in Laryngeal Squamous Cell Carcinomas
Yıl: 2022 Cilt: 54 Sayı: 2 Sayfa Aralığı: 165 - 172 Metin Dili: İngilizce DOI: 10.5152/eurasianjmed.2022.21113 İndeks Tarihi: 05-07-2022
The Importance of Heat Shock-Related 70-kDa Protein 2 Expression in Laryngeal Squamous Cell Carcinomas
Öz: Objective: Laryngeal squamous cell carcinoma has a high mortality rate, and approximately 60% of patients
are in advanced stage at the time of diagnosis. Thus, determining the prognostic parameters of this cancer
and markers related to these parameters are very important. There are studies showing that heat shockrelated
70-kDa protein 2, which is used as a biomarker, may be associated with prognostic parameter in some
cancers. However, no study has investigated the prognostic role of heat shock-related 70-kDa protein 2 in
laryngeal squamous cell carcinoma in the literature. Thus, in our study, the aim was to examine the relationship
between heat shock-related 70-kDa protein 2 expression and clinicopathological prognostic parameters
in laryngeal squamous cell carcinoma.
Materials and Methods: Our study included 104 patients diagnosed with laryngeal squamous cell carcinoma
between January 2005 and January 2016. The correlation between heat shock-related 70-kDa protein
2 expression and prognostic parameters was investigated by using the immunohistochemical method with
heat shock-related 70-kDa protein 2 antibody.
Results: In all the cases, heat shock-related 70-kDa protein 2 positivity was determined in tumoral areas
(100%). The overexpression rate of heat shock-related 70-kDa protein 2 in adjacent non-cancerous tissues
with dysplasia was 48/104 (42%) (P < .0001). A significant relationship was found between heat shockrelated
70-kDa protein 2 expression and important prognostic parameters such as macroscopic tumor
size, lymphovascular invasion, primary tumor, lymph node metastasis, distant organ metastasis, tumor, node,
metastasis (TNM) stage stage, recurrence, and survival rates (P < .05).
Conclusion: Our study supports the presence of an association between high heat shock-related 70-kDa
protein 2 expression levels and prognostic parameters in laryngeal squamous cell carcinoma. We consider
that heat shock-related 70-kDa protein 2 can be used as a prognostic marker in laryngeal squamous cell
carcinoma. In addition, it may be important in early diagnosis due to its increased expression even under
laryngeal squamous cell carcinoma precursor conditions.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- 1. Markou K, Christoforidou A, Karasmanis I, et al. Laryngeal cancer: epidemiological data from Northern Greece and review of the literature. Hippokratia. 2013;17(4):313-318.
- 2. Fong PY, Tan SH, Lim DWT, et al. Association of clinical factors with survival outcomes in laryngeal squamous cell carcinoma (LSCC). PLOS ONE. 2019;14(11):e0224665. [CrossRef]
- 3. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394-424. [CrossRef]
- 4. Ferlay J, Soerjomataram I, Dikshit R, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;136(5):E359-E386. [CrossRef]
- 5. Groome PA, O’Sullivan B, Irish JC, et al. Management and outcome differences in supraglottic cancer between Ontario, Canada, and the surveillance, epidemiology, and end results areas of the United States. J Clin Oncol. 2003;21(3):496- 505. [CrossRef]
- 6. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2016. CA Cancer J Clin. 2016;66(1):7-30. [CrossRef]
- 7. Zhai LL, Xie Q, Zhou CH, Huang DW, Tang ZG, Ju TF. Overexpressed HSPA2 correlates with tumor angiogenesis and unfavorable prognosis in pancreatic carcinoma. Pancreatology. 2017;17(3):457-463. [CrossRef]
- 8. Garg M, Kanojia D, Saini S, et al. Germ cell-specific heat shock protein 70-2 is expressed in cervical carcinoma and is involved in the growth, migration, and invasion of cervical cells. Cancer. 2010;116(16):3785-3796. [CrossRef]
- 9. Garg M, Kanojia D, Seth A, et al. Heat-shock protein 70-2 (HSP70-2) expression in bladder urothelial carcinoma is associated with tumour progression and promotes migration and invasion. Eur J Cancer. 2010;46(1):207-215. [CrossRef]
- 10. Scieglinska D, Piglowski W, Chekan M, Mazurek A, Krawczyk Z. Differential expression of HSPA1 and HSPA2 proteins in human tissues; tissue microarray-based immunohistochemical study. Histochem Cell Biol. 2011;135(4):337-350. [CrossRef]
- 11. Barańska A, Maziarz A, Roliński J, et al. Expression of heat shock protein 70 in the tissue of patients with laryngeal squamous cell carcinoma. Eur J Clin Exp Med. 2019;17(1):16-21. [CrossRef]
- 12. Dix DJ, Allen JW, Collins BW, et al. HSP70-2 is required for desynapsis of synaptonemal complexes during meiotic prophase in juvenile and adult mouse spermatocytes. Development. 1997;124(22):4595-4603. [CrossRef]
- 13. Rohde M, Daugaard M, Jensen MH, Helin K, Nylandsted J, Jäättelä M. Members of the heatshock protein 70 family promote cancer cell growth by distinct mechanisms. Genes Dev. 2005;19(5):570-582. [CrossRef]
- 14. Scieglinska D, Gogler-Piglowska A, Butkiewicz D, et al. HSPA2 is expressed in human tumors and correlates with clinical features in non-small cell lung carcinoma patients. Anticancer Res. 2014;34(6):2833-2840.
- 15. Zhang H, Chen W, Duan CJ, Zhang CF. Overexpression of HSPA2 is correlated with poor prognosis in esophageal squamous cell carcinoma. World J Surg Oncol. 2013;11:141. [CrossRef]
- 16. Jalbout M, Bouaouina N, Gargouri J, Corbex M, Ben Ahmed SB, Chouchane L. Polymorphism of the stress protein HSP70-2 gene is associated with the susceptibility to the nasopharyngeal carcinoma. Cancer Lett. 2003;193(1):75-81. [CrossRef]
- 17. Fu Y, Zhao H, Li XS, et al. Expression of HSPA2 in human hepatocellular carcinoma and its clinical significance. Tumour Biol. 2014;35(11):11283- 11287. [CrossRef]
- 18. Amin MB, Edge SB. AJCC Cancer Staging Manual. Berlin: Springer; 2017.
- 19. Fourie AM, Peterson PA, Yang Y. Characterization and regulation of the major histocompatibility complex–encoded proteins Hsp70-Hom and Hsp70-1/2. Cell Stress Chaperones. 2001;6(3):282- 295. [CrossRef]
- 20. Zhu D, Dix DJ, Eddy EM. HSP70-2 is required for CDC2 kinase activity in meiosis I of mouse spermatocytes. Development. 1997;124(15): 3007-3014. [CrossRef]
- 21. Cao L, Yuan X, Bao F, et al. Downregulation of HSPA2 inhibits proliferation via ERK1/2 pathway and endoplasmic reticular stress in lung adenocarcinoma. Ann Transl Med. 2019;7(20):540. [CrossRef]
- 22. Ścieglińska D, Pigłowski W, Mazurek A, et al. The HspA2 protein localizes in nucleoli and centrosomes of heat shocked cancer cells. J Cell Biochem. 2008;104(6):2193-2206. [CrossRef]
APA | Ceylan O, ARSLAN R (2022). The Importance of Heat Shock-Related 70-kDa Protein 2 Expression in Laryngeal Squamous Cell Carcinomas. , 165 - 172. 10.5152/eurasianjmed.2022.21113 |
Chicago | Ceylan Onur,ARSLAN REMZİ The Importance of Heat Shock-Related 70-kDa Protein 2 Expression in Laryngeal Squamous Cell Carcinomas. (2022): 165 - 172. 10.5152/eurasianjmed.2022.21113 |
MLA | Ceylan Onur,ARSLAN REMZİ The Importance of Heat Shock-Related 70-kDa Protein 2 Expression in Laryngeal Squamous Cell Carcinomas. , 2022, ss.165 - 172. 10.5152/eurasianjmed.2022.21113 |
AMA | Ceylan O,ARSLAN R The Importance of Heat Shock-Related 70-kDa Protein 2 Expression in Laryngeal Squamous Cell Carcinomas. . 2022; 165 - 172. 10.5152/eurasianjmed.2022.21113 |
Vancouver | Ceylan O,ARSLAN R The Importance of Heat Shock-Related 70-kDa Protein 2 Expression in Laryngeal Squamous Cell Carcinomas. . 2022; 165 - 172. 10.5152/eurasianjmed.2022.21113 |
IEEE | Ceylan O,ARSLAN R "The Importance of Heat Shock-Related 70-kDa Protein 2 Expression in Laryngeal Squamous Cell Carcinomas." , ss.165 - 172, 2022. 10.5152/eurasianjmed.2022.21113 |
ISNAD | Ceylan, Onur - ARSLAN, REMZİ. "The Importance of Heat Shock-Related 70-kDa Protein 2 Expression in Laryngeal Squamous Cell Carcinomas". (2022), 165-172. https://doi.org/10.5152/eurasianjmed.2022.21113 |
APA | Ceylan O, ARSLAN R (2022). The Importance of Heat Shock-Related 70-kDa Protein 2 Expression in Laryngeal Squamous Cell Carcinomas. Eurasian Journal of Medicine, 54(2), 165 - 172. 10.5152/eurasianjmed.2022.21113 |
Chicago | Ceylan Onur,ARSLAN REMZİ The Importance of Heat Shock-Related 70-kDa Protein 2 Expression in Laryngeal Squamous Cell Carcinomas. Eurasian Journal of Medicine 54, no.2 (2022): 165 - 172. 10.5152/eurasianjmed.2022.21113 |
MLA | Ceylan Onur,ARSLAN REMZİ The Importance of Heat Shock-Related 70-kDa Protein 2 Expression in Laryngeal Squamous Cell Carcinomas. Eurasian Journal of Medicine, vol.54, no.2, 2022, ss.165 - 172. 10.5152/eurasianjmed.2022.21113 |
AMA | Ceylan O,ARSLAN R The Importance of Heat Shock-Related 70-kDa Protein 2 Expression in Laryngeal Squamous Cell Carcinomas. Eurasian Journal of Medicine. 2022; 54(2): 165 - 172. 10.5152/eurasianjmed.2022.21113 |
Vancouver | Ceylan O,ARSLAN R The Importance of Heat Shock-Related 70-kDa Protein 2 Expression in Laryngeal Squamous Cell Carcinomas. Eurasian Journal of Medicine. 2022; 54(2): 165 - 172. 10.5152/eurasianjmed.2022.21113 |
IEEE | Ceylan O,ARSLAN R "The Importance of Heat Shock-Related 70-kDa Protein 2 Expression in Laryngeal Squamous Cell Carcinomas." Eurasian Journal of Medicine, 54, ss.165 - 172, 2022. 10.5152/eurasianjmed.2022.21113 |
ISNAD | Ceylan, Onur - ARSLAN, REMZİ. "The Importance of Heat Shock-Related 70-kDa Protein 2 Expression in Laryngeal Squamous Cell Carcinomas". Eurasian Journal of Medicine 54/2 (2022), 165-172. https://doi.org/10.5152/eurasianjmed.2022.21113 |