TY  - JOUR
TI  - The Importance of Heat Shock-Related 70-kDa Protein 2 Expression in
Laryngeal Squamous Cell Carcinomas
AB  - Objective: Laryngeal squamous cell carcinoma has a high mortality rate, and approximately 60% of patients
are in advanced stage at the time of diagnosis. Thus, determining the prognostic parameters of this cancer
and markers related to these parameters are very important. There are studies showing that heat shockrelated
70-kDa protein 2, which is used as a biomarker, may be associated with prognostic parameter in some
cancers. However, no study has investigated the prognostic role of heat shock-related 70-kDa protein 2 in
laryngeal squamous cell carcinoma in the literature. Thus, in our study, the aim was to examine the relationship
between heat shock-related 70-kDa protein 2 expression and clinicopathological prognostic parameters
in laryngeal squamous cell carcinoma.
Materials and Methods: Our study included 104 patients diagnosed with laryngeal squamous cell carcinoma
between January 2005 and January 2016. The correlation between heat shock-related 70-kDa protein
2 expression and prognostic parameters was investigated by using the immunohistochemical method with
heat shock-related 70-kDa protein 2 antibody.
Results: In all the cases, heat shock-related 70-kDa protein 2 positivity was determined in tumoral areas
(100%). The overexpression rate of heat shock-related 70-kDa protein 2 in adjacent non-cancerous tissues
with dysplasia was 48/104 (42%) (P < .0001). A significant relationship was found between heat shockrelated
70-kDa protein 2 expression and important prognostic parameters such as macroscopic tumor
size, lymphovascular invasion, primary tumor, lymph node metastasis, distant organ metastasis, tumor, node,
metastasis (TNM) stage stage, recurrence, and survival rates (P < .05).
Conclusion: Our study supports the presence of an association between high heat shock-related 70-kDa
protein 2 expression levels and prognostic parameters in laryngeal squamous cell carcinoma. We consider
that heat shock-related 70-kDa protein 2 can be used as a prognostic marker in laryngeal squamous cell
carcinoma. In addition, it may be important in early diagnosis due to its increased expression even under
laryngeal squamous cell carcinoma precursor conditions.
AU  - Ceylan, Onur
AU  - ARSLAN, REMZİ
DO  - 10.5152/eurasianjmed.2022.21113
PY  - 2022
JO  - Eurasian Journal of Medicine
VL  - 54
IS  - 2
SN  - 1308-8734
SP  - 165
EP  - 172
DB  - TRDizin
UR  - http://search/yayin/detay/530136
ER  -