TY  - JOUR
TI  - High Fetuin-A Levels in Children with Celiac Disease
AB  - Objective: Fetuin-A is a multifunctional non-collagen protein that plays a role in bone mineralization. Celiac
disease is a chronic inflammatory disorder of the small intestine due to exposure to gluten. In this research,
it was aimed to investigate levels of Fetuin-A and its relationship with bone mineral density in children with
celiac disease.
Materials and Methods: The study was conducted on 59 children with celiac and 29 healthy children. The celiac
disease group was composed of three groups, newly diagnosed, gluten-free diet compliant and, non- glutenfree
diet compliant patients. Serum Fetuin-A concentrations were measured by an enzyme-linked immunosorbent
assay kit. Measurement of bone mineral density was performed a dual-energy x-ray absorptiometry.
Results: Serum Fetuin-A levels were 136.85 ± 38.09 μg/L and 112.95 ± 44.39 μg/L in the celiac disease and
healthy control groups, respectively. There was a statistically significant difference between groups in levels of
serum Fetuin-A (P < .05). A significant positive correlation was observed between serum Fetuin-A and bone
mineral density Z-score in the celiac patients.
Conclusion: Increased Fetuin-A levels and positive correlation between Fetuin-A and bone mineral density
in children with celiac disease suggest that Fetuin-A may be a biomarker for celiac disease.
AU  - Gül, Mehmet Ali
AU  - OZGERIS, FATMA BETÜL
AU  - Cayir, Atilla
AU  - KURT, Nezahat
AU  - Volkan, Burcu
DO  - 10.5152/eurasianjmed.2022.21293
PY  - 2022
JO  - Eurasian Journal of Medicine
VL  - 54
IS  - 2
SN  - 1308-8734
SP  - 186
EP  - 190
DB  - TRDizin
UR  - http://search/yayin/detay/530176
ER  -