Do Hipnotic Anesthetic Agents Used in Patients Undergoing Radical Prostatectomy Have An Effect on the Neutrophil/Lymphocyte Ratio? Retrospective Study
Yıl: 2022 Cilt: 9 Sayı: 2 Sayfa Aralığı: 128 - 132 Metin Dili: İngilizce DOI: 10.4274/jus.galenos.2021.2021.0059 İndeks Tarihi: 05-07-2022
Do Hipnotic Anesthetic Agents Used in Patients Undergoing Radical Prostatectomy Have An Effect on the Neutrophil/Lymphocyte Ratio? Retrospective Study
Öz: Objective: Anesthetic agents and applications affect tumor pathophysiology and immunosuppression in the postoperative period. We evaluated the
changes made by hypnotic anesthetic agents used during anesthesia on neutrophil/lymphocyte ratio (NLR) in patients undergoing radical prostate
surgery and its relationship with short-term morbidity.
Materials and Methods: Age of patients who had radical prostatectomy, physical classification of the American Society of Anesthesiology,
perioperative blood transfusion, drugs used during general anesthesia (intravenous, opioid, volatile anesthetic), duration of anesthesia, analgesics
used in postoperative pain was examined. Preoperative, postoperative day-0 and day-2 NLR results were recorded.
Results: The data of 159 patients who underwent radical prostatectomy were assessed. The patients were divided into 2 groups; Group pentotalsevoflurane/desflurane (PSD) (n=101) and Group propofol-sevoflurane/desflurane (PrSD) (n=58). There was no difference in terms of preoperative
and postoperative 2 day NLR value, but the highest NLR values in the postoperative day 0 was found to be in Group PrSD. Postoperative complications
were higher in Group PSD. However, preoperative NLR values of these complications were higher in Group PrSD. Erythrocyte (red blood cell)
replacement patients were divided into 2 groups; between 0 and 2 units (n=147) and more than >2 units (n=12), their preoperative NLR ratios were
2.54 (0.7-16.3) and 3.3 (1.8-8.8) respectively. The cut value of NLR for bleeding was set at 1.77.
Conclusion: Increased NLR result is associated with immunosuppression and tumorigenesis, and is an easy and inexpensive technique. In prostate
cancer, preoperative high NLR (>1.7) may have a predictive value for bleeding, blood transfusion, and postoperative respiratory distress
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- 1. Cao Z, Ji J, Zhang C, Wang F, Xu H, Yu Y, Sun Y. the preoperative neutrophil‐ to‐lymphocyte ratio is not a marker of prostate cancer characteristics but is an independent predictor of biochemical recurrence in patients receiving radical prostatectomy. Cancer Med 2019;8:1004-1012.
- 2. Wuethrich PY, Thalmann GN, Studer UE, Burkhard FC. Epidural analgesia during open radical prostatectomy does not improve long-term cancerrelated outcome: a retrospective study in patients with advanced prostate cancer. PloS One 2013;8:e72873.
- 3. Fant F, Axelsson K, Sandblom D, Magnuson A, Andersson SO, Gupta A. Thoracic epidural analgesia or patient-controlled local analgesia for radical retropubic prostatectomy: a randomized, double-blind study. Br J Anaesth 2011;107:782-789.
- 4. Lusty AJ, Hosier GW, Koti M, Chenard S, Mizubuti GB, Jaeger M, Siemens DR. Anesthetic technique and oncological outcomes in urology: A clinical practice review. Urol Oncol 2019;37:845-852.
- 5. Scavonetto F, Yeoh TY, Umbreit EC, Weingarten TN, Gettman MT, Frank I, Sprung J. Association neuraxial between analgesia, cancer progression, and mortality after radical prostatectomy: a large, retrospective matched cohort study. Br J Anaesth 2014;113(Suppl 1):i95-i102.
- 6. Sfanos KS, De Marzo AM, Prostate cancer and inflammation: the evidence. Histopathology 2012;60:199-215.
- 7. Zhang GM, Zhu Y, Ma XC, Qin XJ, Wan FN, Dai B, Yu DW. Pretreatment Neutrophil to-Lymphocyte Ratio. A Predictor of Advanced Prostate Cancer and Biochemical Recurrence in Patients Receiving Radical Prostatectomy. Medicine (Baltimore) 2015;94:e1473.
- 8. Lee H, Jeong SJ, Hong SK, Byun SS, Lee SE, Oh JJ. High preoperative neutrophil‐lymphocyte ratio predicts biochemical recurrence in patients with localized prostate cancer after radical prostatectomy. World J Urol 2016;34:821‐827.
- 9. Kim R. Effects of surgery and anesthetic choice on immunosuppression and cancer recurrence. J Transl Med 2018;16:8.
- 10. Biki B, Mascha E, Moriarty DC, Fitzpatrick JM, Sessler DI, Buggy DJ. Anesthetic technique for radical prostatectomy surgery affects cancer recurrence: a retrospective analysis. Anesthesiology 2008;109:180-187.
- 11. Mao L, Lin S, Lin J. The effects of anesthetics on tumor progression. Int J Physiol Pathophysiol Pharmacol 2013;5:1-10.
- 12. Looney M, Doran P, Buggy DJ. Effect of anesthetic technique on serum vascular endothelial growth factor C and transforming growth factor beta in women undergoing anesthesia and surgery for breast cancer. Anesthesiology 2010;113:1118-1125.
- 13. Miyamoto R, Inagawa S, Sano N, Tadono S, Adachi S, Yamamoto M, The neutrophil-to-lymphocyte ratio (NLR) predicts short-term and long-term outcomes in gastric cancer patients. Eur J Surg Oncol 2018;44:607-612.
APA | Onay M, Çetinkaya D, özer a, YELKEN B, Özen A, can c (2022). Do Hipnotic Anesthetic Agents Used in Patients Undergoing Radical Prostatectomy Have An Effect on the Neutrophil/Lymphocyte Ratio? Retrospective Study. , 128 - 132. 10.4274/jus.galenos.2021.2021.0059 |
Chicago | Onay Meryem,Çetinkaya Dilek,özer adem,YELKEN BIRGUL BUYUKKIDAN,Özen Ata,can cavit Do Hipnotic Anesthetic Agents Used in Patients Undergoing Radical Prostatectomy Have An Effect on the Neutrophil/Lymphocyte Ratio? Retrospective Study. (2022): 128 - 132. 10.4274/jus.galenos.2021.2021.0059 |
MLA | Onay Meryem,Çetinkaya Dilek,özer adem,YELKEN BIRGUL BUYUKKIDAN,Özen Ata,can cavit Do Hipnotic Anesthetic Agents Used in Patients Undergoing Radical Prostatectomy Have An Effect on the Neutrophil/Lymphocyte Ratio? Retrospective Study. , 2022, ss.128 - 132. 10.4274/jus.galenos.2021.2021.0059 |
AMA | Onay M,Çetinkaya D,özer a,YELKEN B,Özen A,can c Do Hipnotic Anesthetic Agents Used in Patients Undergoing Radical Prostatectomy Have An Effect on the Neutrophil/Lymphocyte Ratio? Retrospective Study. . 2022; 128 - 132. 10.4274/jus.galenos.2021.2021.0059 |
Vancouver | Onay M,Çetinkaya D,özer a,YELKEN B,Özen A,can c Do Hipnotic Anesthetic Agents Used in Patients Undergoing Radical Prostatectomy Have An Effect on the Neutrophil/Lymphocyte Ratio? Retrospective Study. . 2022; 128 - 132. 10.4274/jus.galenos.2021.2021.0059 |
IEEE | Onay M,Çetinkaya D,özer a,YELKEN B,Özen A,can c "Do Hipnotic Anesthetic Agents Used in Patients Undergoing Radical Prostatectomy Have An Effect on the Neutrophil/Lymphocyte Ratio? Retrospective Study." , ss.128 - 132, 2022. 10.4274/jus.galenos.2021.2021.0059 |
ISNAD | Onay, Meryem vd. "Do Hipnotic Anesthetic Agents Used in Patients Undergoing Radical Prostatectomy Have An Effect on the Neutrophil/Lymphocyte Ratio? Retrospective Study". (2022), 128-132. https://doi.org/10.4274/jus.galenos.2021.2021.0059 |
APA | Onay M, Çetinkaya D, özer a, YELKEN B, Özen A, can c (2022). Do Hipnotic Anesthetic Agents Used in Patients Undergoing Radical Prostatectomy Have An Effect on the Neutrophil/Lymphocyte Ratio? Retrospective Study. Journal of Urological Surgery, 9(2), 128 - 132. 10.4274/jus.galenos.2021.2021.0059 |
Chicago | Onay Meryem,Çetinkaya Dilek,özer adem,YELKEN BIRGUL BUYUKKIDAN,Özen Ata,can cavit Do Hipnotic Anesthetic Agents Used in Patients Undergoing Radical Prostatectomy Have An Effect on the Neutrophil/Lymphocyte Ratio? Retrospective Study. Journal of Urological Surgery 9, no.2 (2022): 128 - 132. 10.4274/jus.galenos.2021.2021.0059 |
MLA | Onay Meryem,Çetinkaya Dilek,özer adem,YELKEN BIRGUL BUYUKKIDAN,Özen Ata,can cavit Do Hipnotic Anesthetic Agents Used in Patients Undergoing Radical Prostatectomy Have An Effect on the Neutrophil/Lymphocyte Ratio? Retrospective Study. Journal of Urological Surgery, vol.9, no.2, 2022, ss.128 - 132. 10.4274/jus.galenos.2021.2021.0059 |
AMA | Onay M,Çetinkaya D,özer a,YELKEN B,Özen A,can c Do Hipnotic Anesthetic Agents Used in Patients Undergoing Radical Prostatectomy Have An Effect on the Neutrophil/Lymphocyte Ratio? Retrospective Study. Journal of Urological Surgery. 2022; 9(2): 128 - 132. 10.4274/jus.galenos.2021.2021.0059 |
Vancouver | Onay M,Çetinkaya D,özer a,YELKEN B,Özen A,can c Do Hipnotic Anesthetic Agents Used in Patients Undergoing Radical Prostatectomy Have An Effect on the Neutrophil/Lymphocyte Ratio? Retrospective Study. Journal of Urological Surgery. 2022; 9(2): 128 - 132. 10.4274/jus.galenos.2021.2021.0059 |
IEEE | Onay M,Çetinkaya D,özer a,YELKEN B,Özen A,can c "Do Hipnotic Anesthetic Agents Used in Patients Undergoing Radical Prostatectomy Have An Effect on the Neutrophil/Lymphocyte Ratio? Retrospective Study." Journal of Urological Surgery, 9, ss.128 - 132, 2022. 10.4274/jus.galenos.2021.2021.0059 |
ISNAD | Onay, Meryem vd. "Do Hipnotic Anesthetic Agents Used in Patients Undergoing Radical Prostatectomy Have An Effect on the Neutrophil/Lymphocyte Ratio? Retrospective Study". Journal of Urological Surgery 9/2 (2022), 128-132. https://doi.org/10.4274/jus.galenos.2021.2021.0059 |