Increasing the biocompatibility of graphene-based hybrid nanostructures with glycopolymer

Zengin Kurt, Belma; OMURTAG OZGEN, PINAR SINEM; Durmus, Zehra; Dag, Aydan

doi:10.3906/kim-2109-60

Increasing the biocompatibility of graphene-based hybrid nanostructures with glycopolymer

Aydan DAĞ, (Bezmialem Vakıf Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı, İstanbul, Türkiye)

Pınar Sinem OMURTAG ÖZGEN, (Bezmialem Vakıf Üniversitesi, İlaç Uygulama ve Araştırma Merkezi, İstanbul, Türkiye)

Belma ZENGİN KURT, (Bezmialem Vakıf Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı, İstanbul, Türkiye)

Zehra DURMUŞ (İstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Analitik Kimya Anabilim Dalı, İstanbul, Türkiye)

Turkish Journal of Chemistry

3 0

Yıl: 2022 Cilt: 46 Sayı: 2 Sayfa Aralığı: 404 - 414 Metin Dili: İngilizce DOI: 10.3906/kim-2109-60 İndeks Tarihi: 05-07-2022

Increasing the biocompatibility of graphene-based hybrid nanostructures with glycopolymer

Öz:

Hybrid nanostructures decorated with glycopolymers are appropriate for biomedical applications. In this paper, the results are obtained from nanographene (NG) decorated with glycoblock copolymer to increase their potential in use in therapies and in examining lectin interactions. A pyren-1-ylmethyl 4-cyano-4-((phenylcarbonothioyl)thio)pentanoate (CPADB-py) chain transfer agent was used in the synthesis of methyl methacrylate glycoblock copolymers (P2 and P3) by reversible addition-fragmentation chain transfer (RAFT) polymerization to adhere the polymer to the nanographene surface. Hybrid nanographenes (NG-1 and NG-2) were obtained by the non-covalent interaction of deprotected P2 and P3 with different fructopyranose groups (3-O-methacryloyl-1,2:4,5- di-O-isopropylidene-β-D-fructopyranose and 1-O-methacryloyl-2,3:4,5-di-O-isopropylidene-β-D-fructopyranose) in their backbones. Images obtained from transmission electron microscopy (TEM) of NG-1 and NG-2 show that glycoblock copolymer coating was performed homogeneously. Moreover, thermal gravimetric analysis (TGA) also confirmed a glycoblock copolymer coating of NG-1 and NG-2 by weight loss of 41% and 31%, respectively. In the last step of the study, the binding ability of glycoblock copolymers (P2-hyd and P3-hyd) with concanavalin A (ConA) lectin was investigated by a turbidimetric assay. Promising results were obtained from P3-hyd for the ConA interactions. Hence, this study may open a new avenue in the design of new multifunctional glyconanomaterials that show favorable binding properties with lectins.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Dag A, OMURTAG OZGEN P, Zengin Kurt B, Durmus Z (2022). Increasing the biocompatibility of graphene-based hybrid nanostructures with glycopolymer. , 404 - 414. 10.3906/kim-2109-60
Chicago	Dag Aydan,OMURTAG OZGEN PINAR SINEM,Zengin Kurt Belma,Durmus Zehra Increasing the biocompatibility of graphene-based hybrid nanostructures with glycopolymer. (2022): 404 - 414. 10.3906/kim-2109-60
MLA	Dag Aydan,OMURTAG OZGEN PINAR SINEM,Zengin Kurt Belma,Durmus Zehra Increasing the biocompatibility of graphene-based hybrid nanostructures with glycopolymer. , 2022, ss.404 - 414. 10.3906/kim-2109-60
AMA	Dag A,OMURTAG OZGEN P,Zengin Kurt B,Durmus Z Increasing the biocompatibility of graphene-based hybrid nanostructures with glycopolymer. . 2022; 404 - 414. 10.3906/kim-2109-60
Vancouver	Dag A,OMURTAG OZGEN P,Zengin Kurt B,Durmus Z Increasing the biocompatibility of graphene-based hybrid nanostructures with glycopolymer. . 2022; 404 - 414. 10.3906/kim-2109-60
IEEE	Dag A,OMURTAG OZGEN P,Zengin Kurt B,Durmus Z "Increasing the biocompatibility of graphene-based hybrid nanostructures with glycopolymer." , ss.404 - 414, 2022. 10.3906/kim-2109-60
ISNAD	Dag, Aydan vd. "Increasing the biocompatibility of graphene-based hybrid nanostructures with glycopolymer". (2022), 404-414. https://doi.org/10.3906/kim-2109-60

APA	Dag A, OMURTAG OZGEN P, Zengin Kurt B, Durmus Z (2022). Increasing the biocompatibility of graphene-based hybrid nanostructures with glycopolymer. Turkish Journal of Chemistry, 46(2), 404 - 414. 10.3906/kim-2109-60
Chicago	Dag Aydan,OMURTAG OZGEN PINAR SINEM,Zengin Kurt Belma,Durmus Zehra Increasing the biocompatibility of graphene-based hybrid nanostructures with glycopolymer. Turkish Journal of Chemistry 46, no.2 (2022): 404 - 414. 10.3906/kim-2109-60
MLA	Dag Aydan,OMURTAG OZGEN PINAR SINEM,Zengin Kurt Belma,Durmus Zehra Increasing the biocompatibility of graphene-based hybrid nanostructures with glycopolymer. Turkish Journal of Chemistry, vol.46, no.2, 2022, ss.404 - 414. 10.3906/kim-2109-60
AMA	Dag A,OMURTAG OZGEN P,Zengin Kurt B,Durmus Z Increasing the biocompatibility of graphene-based hybrid nanostructures with glycopolymer. Turkish Journal of Chemistry. 2022; 46(2): 404 - 414. 10.3906/kim-2109-60
Vancouver	Dag A,OMURTAG OZGEN P,Zengin Kurt B,Durmus Z Increasing the biocompatibility of graphene-based hybrid nanostructures with glycopolymer. Turkish Journal of Chemistry. 2022; 46(2): 404 - 414. 10.3906/kim-2109-60
IEEE	Dag A,OMURTAG OZGEN P,Zengin Kurt B,Durmus Z "Increasing the biocompatibility of graphene-based hybrid nanostructures with glycopolymer." Turkish Journal of Chemistry, 46, ss.404 - 414, 2022. 10.3906/kim-2109-60
ISNAD	Dag, Aydan vd. "Increasing the biocompatibility of graphene-based hybrid nanostructures with glycopolymer". Turkish Journal of Chemistry 46/2 (2022), 404-414. https://doi.org/10.3906/kim-2109-60