Yıl: 2022 Cilt: 14 Sayı: 2 Sayfa Aralığı: 179 - 187 Metin Dili: İngilizce DOI: 10.4274/jcrpe.galenos.2021.2021-11-1 İndeks Tarihi: 05-07-2022

Low Complement C1q/TNF-related Protein-13 Levels are Associated with Childhood Obesity But not Binge Eating Disorder

Öz:
Objective: C1q/tumor necrosis factor-related proteins (CTRPs) are recently described members of the adipokine family. CTRP-13, a new member of this family, has been shown to increase insulin sensitivity and had an anorexigenic effect on food intake in experimental studies. The aim was to investigate serum CTRP-13 levels in children with obesity, and its relationship with other adipokines, metabolic parameters, or binge eating disorder (BED). Methods: A cross-sectional study was conducted with 105 pubertal children attending a single center. Clinical (metabolic syndrome, BED) and biochemical (glucose, insulin, lipids, leptin, adiponectin, CTRP-13 levels) parameters were assessed. Results: Sixty children with obesity [24 males (40%); median age 14.7 (13.0-16.4) years] and 45 healthy controls [15 males (33.3%); median age 15.2 (14.1-16.5) years] were included. Serum adiponectin and CTRP-13 levels were significantly lower in children with obesity than controls (7.1 vs 20.1 μg/mL, p<0.001; 64.7 vs 103.8 ng/mL, p<0.001, respectively). CTRP-13 levels correlated negatively with body mass index (Spearman rho=-0.230, p=0.018) and positively with high-density lipoprotein-cholesterol levels (Spearman rho=0.218, p=0.026). There was no significant difference in serum CTRP-13 concentrations in terms of the presence of metabolic syndrome or BED. Conclusion: Childhood obesity seems to be causing dysregulation in adipokine production and function, including the down-regulation of CTRP-13. The positive correlation between CTRP-13 and HDL-C levels suggested a possible effect of this adipokine on lipid metabolism. Thus CTRP-13 may be a novel biomarker for dyslipidemia in childhood obesity.
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APA Erbas I, PAKETÇİ A, TURAN S, Şişman A, Demir K, Bober E, Abaci A (2022). Low Complement C1q/TNF-related Protein-13 Levels are Associated with Childhood Obesity But not Binge Eating Disorder. , 179 - 187. 10.4274/jcrpe.galenos.2021.2021-11-1
Chicago Erbas Ibrahim Mert,PAKETÇİ AHU,TURAN SERKAN,Şişman Ali Rıza,Demir Korcan,Bober Ece,Abaci Ayhan Low Complement C1q/TNF-related Protein-13 Levels are Associated with Childhood Obesity But not Binge Eating Disorder. (2022): 179 - 187. 10.4274/jcrpe.galenos.2021.2021-11-1
MLA Erbas Ibrahim Mert,PAKETÇİ AHU,TURAN SERKAN,Şişman Ali Rıza,Demir Korcan,Bober Ece,Abaci Ayhan Low Complement C1q/TNF-related Protein-13 Levels are Associated with Childhood Obesity But not Binge Eating Disorder. , 2022, ss.179 - 187. 10.4274/jcrpe.galenos.2021.2021-11-1
AMA Erbas I,PAKETÇİ A,TURAN S,Şişman A,Demir K,Bober E,Abaci A Low Complement C1q/TNF-related Protein-13 Levels are Associated with Childhood Obesity But not Binge Eating Disorder. . 2022; 179 - 187. 10.4274/jcrpe.galenos.2021.2021-11-1
Vancouver Erbas I,PAKETÇİ A,TURAN S,Şişman A,Demir K,Bober E,Abaci A Low Complement C1q/TNF-related Protein-13 Levels are Associated with Childhood Obesity But not Binge Eating Disorder. . 2022; 179 - 187. 10.4274/jcrpe.galenos.2021.2021-11-1
IEEE Erbas I,PAKETÇİ A,TURAN S,Şişman A,Demir K,Bober E,Abaci A "Low Complement C1q/TNF-related Protein-13 Levels are Associated with Childhood Obesity But not Binge Eating Disorder." , ss.179 - 187, 2022. 10.4274/jcrpe.galenos.2021.2021-11-1
ISNAD Erbas, Ibrahim Mert vd. "Low Complement C1q/TNF-related Protein-13 Levels are Associated with Childhood Obesity But not Binge Eating Disorder". (2022), 179-187. https://doi.org/10.4274/jcrpe.galenos.2021.2021-11-1
APA Erbas I, PAKETÇİ A, TURAN S, Şişman A, Demir K, Bober E, Abaci A (2022). Low Complement C1q/TNF-related Protein-13 Levels are Associated with Childhood Obesity But not Binge Eating Disorder. Journal of Clinical Research in Pediatric Endocrinology, 14(2), 179 - 187. 10.4274/jcrpe.galenos.2021.2021-11-1
Chicago Erbas Ibrahim Mert,PAKETÇİ AHU,TURAN SERKAN,Şişman Ali Rıza,Demir Korcan,Bober Ece,Abaci Ayhan Low Complement C1q/TNF-related Protein-13 Levels are Associated with Childhood Obesity But not Binge Eating Disorder. Journal of Clinical Research in Pediatric Endocrinology 14, no.2 (2022): 179 - 187. 10.4274/jcrpe.galenos.2021.2021-11-1
MLA Erbas Ibrahim Mert,PAKETÇİ AHU,TURAN SERKAN,Şişman Ali Rıza,Demir Korcan,Bober Ece,Abaci Ayhan Low Complement C1q/TNF-related Protein-13 Levels are Associated with Childhood Obesity But not Binge Eating Disorder. Journal of Clinical Research in Pediatric Endocrinology, vol.14, no.2, 2022, ss.179 - 187. 10.4274/jcrpe.galenos.2021.2021-11-1
AMA Erbas I,PAKETÇİ A,TURAN S,Şişman A,Demir K,Bober E,Abaci A Low Complement C1q/TNF-related Protein-13 Levels are Associated with Childhood Obesity But not Binge Eating Disorder. Journal of Clinical Research in Pediatric Endocrinology. 2022; 14(2): 179 - 187. 10.4274/jcrpe.galenos.2021.2021-11-1
Vancouver Erbas I,PAKETÇİ A,TURAN S,Şişman A,Demir K,Bober E,Abaci A Low Complement C1q/TNF-related Protein-13 Levels are Associated with Childhood Obesity But not Binge Eating Disorder. Journal of Clinical Research in Pediatric Endocrinology. 2022; 14(2): 179 - 187. 10.4274/jcrpe.galenos.2021.2021-11-1
IEEE Erbas I,PAKETÇİ A,TURAN S,Şişman A,Demir K,Bober E,Abaci A "Low Complement C1q/TNF-related Protein-13 Levels are Associated with Childhood Obesity But not Binge Eating Disorder." Journal of Clinical Research in Pediatric Endocrinology, 14, ss.179 - 187, 2022. 10.4274/jcrpe.galenos.2021.2021-11-1
ISNAD Erbas, Ibrahim Mert vd. "Low Complement C1q/TNF-related Protein-13 Levels are Associated with Childhood Obesity But not Binge Eating Disorder". Journal of Clinical Research in Pediatric Endocrinology 14/2 (2022), 179-187. https://doi.org/10.4274/jcrpe.galenos.2021.2021-11-1