TY  - JOUR
TI  - Aberrant Activation-Induced Cytidine Deaminase
Gene Expression Links BCR/ABL1-Negative Classical
Myeloproliferative Neoplasms
AB  - Aim: Activation-induced cytidine deaminase (AID) has been associated with tumor initiation and development because of its ability to
generate DNA damage and somatic mutations that cause genomic instability. This study aimed to investigate the relationship between
AID expression levels and the risk of developing BCR/ABL1-negative myeloproliferative neoplasms (MPNs) by comparing the AID
expression levels of the patients and controls.
Methods: This case-control study was conducted on 117 cases (64 essential thrombocythemia, 23 primary myelofibrosis, and 30
polycythemia vera) with MPNs and 69 healthy controls. The JAK2 V617F somatic mutation analysis was performed using a real-time
polymerase chain reaction (RT-PCR). The relative expression levels of AID in the patient and the control groups were analyzed using
quantitative RT-PCR and the 2-ΔΔCT method.
Results: AID expression levels were significantly higher in the patient group compared to the control group (p<0.001). AID expression
levels were higher in patients with the JAK2 V617F mutation compared to patients without the mutation, but the difference was not
statistically significant.
Conclusion: The results of our study suggest that although overexpression of AID does not seem to support the JAK2 driver gene, it
may contribute to the development of MPNs through other mechanisms.
AU  - gelmez, metin yusuf
AU  - Daglar Aday, Aynur
AU  - YAVUZ, AKIF SELIM
AU  - Nalcaci, Meliha
AU  - hancer, veysel sabri
AU  - Dermenci, Hasan
AU  - Akadam Teker, Ayşegül Başak
DO  - 10.4274/haseki.galenos.2022.8133
PY  - 2022
JO  - Haseki Tıp Bülteni
VL  - 60
IS  - 3
SN  - 1302-0072
SP  - 228
EP  - 233
DB  - TRDizin
UR  - http://search/yayin/detay/530948
ER  -