TY  - JOUR
TI  - WHAT IS EPIGENETIC CHANGE AND WHAT DO WE KNOW ABOUT ITS IMPACT ON MOLECULAR PATHOLOGIC MECHANISMS OF THE DISEASES?
AB  - Epigenetic change refers to a phenotypic alteration
without permanent genotypic change, which occurs
through chromatin modification, DNA methylation,
histone modification, chromatin-regulating proteins
and non-coding RNAs. Post-transcriptional m6A
RNA methylation is also a newly described epigenetic
mechanism and believed to be a new diagnostic
biomarker and potential therapeutic target. It is a well-
known fact that epigenetic changes play a significant
role in the development and progression of several
nonneoplastic and neoplastic diseases. Therefore,
epigenetic changes are of value in diagnostic
and prognostic terms. On the other hand, with the
development of personalized medicine and targeted
treatment approaches, treatment strategies targeting
the epigenetic changes are becoming a promising
area for many diseases. The aim of this review is
to provide information about the mechanisms of
epigenetic changes and their role in the development
of neoplastic and nonneoplastic diseases, which may
be helpful for the clinicians and laboratory medicine
experts for further researchs.
AU  - Unlu, Mehtat
AU  - BOZKURT, KEMAL KÜRŞAT
AU  - Öztürk, Rafet Güneş
AU  - Ertunc, Onur
AU  - CAKIR, Yasemin
AU  - SAGNAK YILMAZ, Zeynep
AU  - Tan, Ayca
DO  - 10.17343/sdutfd.1090522
PY  - 2022
JO  - Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi
VL  - 29
IS  - 2
SN  - 1300-7416
SP  - 273
EP  - 283
DB  - TRDizin
UR  - http://search/yayin/detay/530982
ER  -