TY  - JOUR
TI  - Assessment of Cardiac Autonomic Functions by 
Heart Rate Recovery Indices in Patients Receiving 
Chest Radiotherapy
AB  - Objective: Although the introduction of radiation therapy for the management of thoracic malignancies has led to a significant 
improvement in disease-specific survival, this has resulted in the emergence of a new spectrum of cardiovascular disorders 
induced by radiation injury. Heart rate recovery, as a predictor of cardiovascular events and an indicator of autonomic functions, 
is measured non-invasively and easily. In the present study, we investigated the effects of mediastinal radiotherapy on heart 
rate recovery parameters.
Methods: Twenty-one patients were included in this study who were planned to receive chest radiotherapy because of lymphoma or lung cancer. Heart rate recovery parameters were evaluated by treadmill exercise before and after radiotherapy.
Results: We have found decrease in heart rate recovery parameters (26.05 ± 12.54 vs. 19.52 ± 12.28 for HRR1, 39.1 ± 16.15 vs. 
32.86 ± 14.83 for HRR2, 42.81 ± 17.66 vs. 38.05 ± 16.14 for HRR3). The higher doses of mediastinal radiotherapy caused significant changes on heart rate recovery parameters. HRR1 changed from 25.70 ± 15.12 to 22.00 ± 14.38 in low dose group and 
from 26.36 ± 10.41 to 17.27 ± 10.10 in high-dose group (P < .05). Attenuation of HRR2 and HRR3 were also more evident in high 
mediastinal dose group (P < .05).
Conclusion: Heart rate recovery parameters were decreased especially in patients who were exposed to more intense mediastinal radiation.
AU  - Fatihoglu, Sefik Gorkem
AU  - HOSROVZADE, Elvin
AU  - Kocyigit Burunkaya, Duygu
AU  - YORGUN, HIKMET
AU  - AYTEMIR, KUDRET
AU  - Şahiner, Mehmet Levent
AU  - MAHARJAN, Naresh
AU  - ATES, AHMET HAKAN
AU  - Cengiz, Mustafa
AU  - Yazici, Gozde
AU  - KAYA, ERGUN BARIS
DO  - 10.54614/eurjther.2021.0088
PY  - 2022
JO  - European Journal of Therapeutics
VL  - 28
IS  - 2
SN  - 2564-7784
SP  - 128
EP  - 134
DB  - TRDizin
UR  - http://search/yayin/detay/531224
ER  -