TY  - JOUR
TI  - The relationship between clinicopathological
parameters and PD-L1 expression level in
advanced stage non-small cell lung cancer
AB  - Introduction: Clinicopathological parameters related to programmed death
ligand 1 (PD-L1) expression levels have been investigated in several studies.
However, the results of these studies are conflicting and vary in different
populations. This study aimed to investigate the relation of clinicopathological
parameters with PD-L1 expression level in advanced stage non-small cell lung
cancer patients.
Materials and Methods: The patients diagnosed with non-small cell lung cancer
were enrolled, retrospectively. The data of clinicopathological parameters
was collected. Clinicopathological parameters in relation to PD-L1 expression
levels (0%, 1-50%, and >50%) were analyzed as univariable and multivariable.
Results: In total, 384 patients were enrolled. PD-L1 expression in tumor cells
was between 1-50%, and >50% in 41.4%, and 23.4% of patients, respectively.
There was no PD-L1 expression in 35.2% of the patients. In univariable
analysis, we found that the parameters associated with PD-L1 expression
levels revealed that metastatic site number, the subtype of cancer, diagnostic
material type, platelet number, and LDH level were statistically significant.
Adenocarcinoma frequency was higher in tumors that had PD-L1 expression
>50% than in tumors that did not express PD-L1 and the difference was statistically significant (p= 0.04, coefficient= 0.3, 95% CI 0.09-0.94). Cytology as diagnostic material was significant in PD-L1 level
1-50% comparing to >50% (p= 0.02, coefficient= 2.2, 95% CI= 1.08-4.46).
Conclusion: According to the results of our study, many of the clinicopathological parameters are not related to the PD-L1 level. The
histological subtype and diagnostic material may affect the level of PD-L1 expression.
AU  - AKKUS, ERMAN
AU  - ceyhan, koray
AU  - Özakıncı, Hilal
AU  - Dizbay Sak, Serpil
AU  - BAGLAN, TOLGA
AU  - Demirkazik, Ahmet
AU  - utkan, gungor
AU  - Dogan, Izzet
AU  - koksoy, elif berna
AU  - Kubilay Tolunay, Pınar
AU  - Kalacı, Ender
AU  - Aydiner, Adnan
AU  - Gürbüz, Mustafa
DO  - 10.5578/tt.20229803
PY  - 2022
JO  - Tüberküloz ve Toraks
VL  - 70
IS  - 2
SN  - 0494-1373
SP  - 132
EP  - 140
DB  - TRDizin
UR  - http://search/yayin/detay/531225
ER  -