Synthesis of quaternized zinc(II) and cobalt(II) phthalocyanines bearing
pyridine-2-yl-ethynyl groups and their DNA binding properties

SESALAN, Behice Şebnem; ÖZÇEŞMECİ, İbrahim; ALISHAH, Maryam MOEINI; YEİLMEZ, Hacer Yasemin; BAYIR, Zehra ALTUNTAŞ

doi:10.3906/kim-1707-54

Synthesis of quaternized zinc(II) and cobalt(II) phthalocyanines bearing pyridine-2-yl-ethynyl groups and their DNA binding properties

Maryam MOEINI ALISHAH, (İstanbul Teknik Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü, İstanbul, Türkiye)

Hacer Yasemin YEİLMEZ, (İstanbul Teknik Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü, İstanbul, Türkiye)

İbrahim ÖZÇEŞMECİ, (İstanbul Teknik Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü, İstanbul, Türkiye)

Behice Şebnem SESALAN, (İstanbul Teknik Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü, İstanbul, Türkiye)

Zehra ALTUNTAŞ BAYIR (İstanbul Teknik Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü, İstanbul, Türkiye)

Turkish Journal of Chemistry

2 0

Yıl: 2018 Cilt: 42 Sayı: 2 Sayfa Aralığı: 572 - 585 Metin Dili: İngilizce DOI: 10.3906/kim-1707-54 İndeks Tarihi: 06-07-2022

Synthesis of quaternized zinc(II) and cobalt(II) phthalocyanines bearing pyridine-2-yl-ethynyl groups and their DNA binding properties

Öz:

The synthesis and biological properties of tetra-substituted zinc and cobalt phthalocyanines bearing ethynylpyridine units on the periphery and their quaternized derivatives have been reported. The binding of quaternized ZnPc and CoPc (Q-ZnPc and Q-CoPc) with calf thymus DNA was investigated by UV-Vis spectrophotometric methods and thermodynamics. The mixtures of Q-ZnPc or Q-CoPc and DNA solutions were used to determine the change in the thermal melting temperature of DNA with the thermal denaturation profile. Thermodynamic parameters that show the spontaneity of the reactions between DNA and the quaternized phthalocyanines were investigated. $K_b$ binding constants at a degree of $10^5 and 10^6$ for Q-ZnPc and Q-CoPc, respectively, showed that the phthalocyanines bound to DNA fragments efficiently and thermodynamic data proved that the binding process was spontaneous and entropy-driven. The interactions between Q-ZnPc and Q-CoPc and DNA in an aqueous environment corresponded to electrostatic attractions and nonspecific binding.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ALISHAH M, YEİLMEZ H, ÖZÇEŞMECİ İ, SESALAN B, BAYIR Z (2018). Synthesis of quaternized zinc(II) and cobalt(II) phthalocyanines bearing pyridine-2-yl-ethynyl groups and their DNA binding properties. , 572 - 585. 10.3906/kim-1707-54
Chicago	ALISHAH Maryam MOEINI,YEİLMEZ Hacer Yasemin,ÖZÇEŞMECİ İbrahim,SESALAN Behice Şebnem,BAYIR Zehra ALTUNTAŞ Synthesis of quaternized zinc(II) and cobalt(II) phthalocyanines bearing pyridine-2-yl-ethynyl groups and their DNA binding properties. (2018): 572 - 585. 10.3906/kim-1707-54
MLA	ALISHAH Maryam MOEINI,YEİLMEZ Hacer Yasemin,ÖZÇEŞMECİ İbrahim,SESALAN Behice Şebnem,BAYIR Zehra ALTUNTAŞ Synthesis of quaternized zinc(II) and cobalt(II) phthalocyanines bearing pyridine-2-yl-ethynyl groups and their DNA binding properties. , 2018, ss.572 - 585. 10.3906/kim-1707-54
AMA	ALISHAH M,YEİLMEZ H,ÖZÇEŞMECİ İ,SESALAN B,BAYIR Z Synthesis of quaternized zinc(II) and cobalt(II) phthalocyanines bearing pyridine-2-yl-ethynyl groups and their DNA binding properties. . 2018; 572 - 585. 10.3906/kim-1707-54
Vancouver	ALISHAH M,YEİLMEZ H,ÖZÇEŞMECİ İ,SESALAN B,BAYIR Z Synthesis of quaternized zinc(II) and cobalt(II) phthalocyanines bearing pyridine-2-yl-ethynyl groups and their DNA binding properties. . 2018; 572 - 585. 10.3906/kim-1707-54
IEEE	ALISHAH M,YEİLMEZ H,ÖZÇEŞMECİ İ,SESALAN B,BAYIR Z "Synthesis of quaternized zinc(II) and cobalt(II) phthalocyanines bearing pyridine-2-yl-ethynyl groups and their DNA binding properties." , ss.572 - 585, 2018. 10.3906/kim-1707-54
ISNAD	ALISHAH, Maryam MOEINI vd. "Synthesis of quaternized zinc(II) and cobalt(II) phthalocyanines bearing pyridine-2-yl-ethynyl groups and their DNA binding properties". (2018), 572-585. https://doi.org/10.3906/kim-1707-54

APA	ALISHAH M, YEİLMEZ H, ÖZÇEŞMECİ İ, SESALAN B, BAYIR Z (2018). Synthesis of quaternized zinc(II) and cobalt(II) phthalocyanines bearing pyridine-2-yl-ethynyl groups and their DNA binding properties. Turkish Journal of Chemistry, 42(2), 572 - 585. 10.3906/kim-1707-54
Chicago	ALISHAH Maryam MOEINI,YEİLMEZ Hacer Yasemin,ÖZÇEŞMECİ İbrahim,SESALAN Behice Şebnem,BAYIR Zehra ALTUNTAŞ Synthesis of quaternized zinc(II) and cobalt(II) phthalocyanines bearing pyridine-2-yl-ethynyl groups and their DNA binding properties. Turkish Journal of Chemistry 42, no.2 (2018): 572 - 585. 10.3906/kim-1707-54
MLA	ALISHAH Maryam MOEINI,YEİLMEZ Hacer Yasemin,ÖZÇEŞMECİ İbrahim,SESALAN Behice Şebnem,BAYIR Zehra ALTUNTAŞ Synthesis of quaternized zinc(II) and cobalt(II) phthalocyanines bearing pyridine-2-yl-ethynyl groups and their DNA binding properties. Turkish Journal of Chemistry, vol.42, no.2, 2018, ss.572 - 585. 10.3906/kim-1707-54
AMA	ALISHAH M,YEİLMEZ H,ÖZÇEŞMECİ İ,SESALAN B,BAYIR Z Synthesis of quaternized zinc(II) and cobalt(II) phthalocyanines bearing pyridine-2-yl-ethynyl groups and their DNA binding properties. Turkish Journal of Chemistry. 2018; 42(2): 572 - 585. 10.3906/kim-1707-54
Vancouver	ALISHAH M,YEİLMEZ H,ÖZÇEŞMECİ İ,SESALAN B,BAYIR Z Synthesis of quaternized zinc(II) and cobalt(II) phthalocyanines bearing pyridine-2-yl-ethynyl groups and their DNA binding properties. Turkish Journal of Chemistry. 2018; 42(2): 572 - 585. 10.3906/kim-1707-54
IEEE	ALISHAH M,YEİLMEZ H,ÖZÇEŞMECİ İ,SESALAN B,BAYIR Z "Synthesis of quaternized zinc(II) and cobalt(II) phthalocyanines bearing pyridine-2-yl-ethynyl groups and their DNA binding properties." Turkish Journal of Chemistry, 42, ss.572 - 585, 2018. 10.3906/kim-1707-54
ISNAD	ALISHAH, Maryam MOEINI vd. "Synthesis of quaternized zinc(II) and cobalt(II) phthalocyanines bearing pyridine-2-yl-ethynyl groups and their DNA binding properties". Turkish Journal of Chemistry 42/2 (2018), 572-585. https://doi.org/10.3906/kim-1707-54