TY  - JOUR
TI  - Synthesis of quaternized zinc(II) and cobalt(II) phthalocyanines bearing
pyridine-2-yl-ethynyl groups and their DNA binding properties
AB  - The synthesis and biological properties of tetra-substituted zinc and cobalt phthalocyanines bearing ethynylpyridine units on the periphery and their quaternized derivatives have been reported. The binding of quaternized ZnPc and CoPc (Q-ZnPc and Q-CoPc) with calf thymus DNA was investigated by UV-Vis spectrophotometric methods and thermodynamics. The mixtures of Q-ZnPc or Q-CoPc and DNA solutions were used to determine the change in the thermal melting temperature of DNA with the thermal denaturation profile. Thermodynamic parameters that show the spontaneity of the reactions between DNA and the quaternized phthalocyanines were investigated. $K_b$ binding constants at a degree of $10^5 and 10^6$ for Q-ZnPc and Q-CoPc, respectively, showed that the phthalocyanines bound to DNA fragments efficiently and thermodynamic data proved that the binding process was spontaneous and entropy-driven. The interactions between Q-ZnPc and Q-CoPc and DNA in an aqueous environment corresponded to electrostatic attractions and nonspecific binding.
AU  - SESALAN, Behice Şebnem
AU  - ÖZÇEŞMECİ, İbrahim
AU  - ALISHAH, Maryam MOEINI
AU  - YEİLMEZ, Hacer Yasemin
AU  - BAYIR, Zehra ALTUNTAŞ
DO  - 10.3906/kim-1707-54
PY  - 2018
JO  - Turkish Journal of Chemistry
VL  - 42
IS  - 2
SN  - 1300-0527
SP  - 572
EP  - 585
DB  - TRDizin
UR  - http://search/yayin/detay/531249
ER  -