Role of lncRNA Alterations in Cervical Oncogenesis

Objectives: Human Papillomavirus (HPV) is the main contributor to the development of cervical cancer. This study aimed to investigate the biological significance of changes in the expression of lncRNAs induced by HPV oncoproteins in cervical oncogenesis mechanisms. Methods: We performed a review using online databases. The alterations were associated with some molecular and/or cellular characteristics that could be involved in the pathogenesis of cervical cancer. The molecular targets of the RNAs were identified using the Gene Expression Profiling Interactive Analysis (GEPIA) bioinformatics sites/tools, GeneCards®, OMIM, and Lnc2Cancer 3.0. Results: Sixty-one altered lncRNAs were identified. The alterations contribute to the higher staging of cervical cancer and a worse prognosis. These lncRNAs can act by competing for miRNAs for response elements, influencing the regulation of target genes and, ultimately, participating in the cancer regulation process and exhibit multiple biological functions, such as chromatin modification, transcription, translation, splicing, and epigenetic regulation. Conclusion: Changes in lncRNA expression have been associated with the onset, progression, and prognosis of cervical cancer. These changes can contribute to several features of cervical oncogenesis, and their identification has the potential to provide new biomarkers and therapeutic targets for the treatment of this cancer.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

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APA	OLIVIEIRA A, Duarte de Almeida V, Posada T, Estevam Carvalho A, Wojcieszyn V, Andrade M, Gurgel Cosme do Nascimento E, Pereira W, Fernandes J, Fernandes T (2022). Role of lncRNA Alterations in Cervical Oncogenesis. , 111 - 120. 10.14744/ejmo.2022.74937
Chicago	OLIVIEIRA Alan Lopes de Oliveira,Duarte de Almeida Valeria,Posada Tauê,Estevam Carvalho Aline,Wojcieszyn Victor,Andrade Micassio,Gurgel Cosme do Nascimento Ellany,Pereira Wogelsanger,Fernandes José Veríssimo,Fernandes Thales Role of lncRNA Alterations in Cervical Oncogenesis. (2022): 111 - 120. 10.14744/ejmo.2022.74937
MLA	OLIVIEIRA Alan Lopes de Oliveira,Duarte de Almeida Valeria,Posada Tauê,Estevam Carvalho Aline,Wojcieszyn Victor,Andrade Micassio,Gurgel Cosme do Nascimento Ellany,Pereira Wogelsanger,Fernandes José Veríssimo,Fernandes Thales Role of lncRNA Alterations in Cervical Oncogenesis. , 2022, ss.111 - 120. 10.14744/ejmo.2022.74937
AMA	OLIVIEIRA A,Duarte de Almeida V,Posada T,Estevam Carvalho A,Wojcieszyn V,Andrade M,Gurgel Cosme do Nascimento E,Pereira W,Fernandes J,Fernandes T Role of lncRNA Alterations in Cervical Oncogenesis. . 2022; 111 - 120. 10.14744/ejmo.2022.74937
Vancouver	OLIVIEIRA A,Duarte de Almeida V,Posada T,Estevam Carvalho A,Wojcieszyn V,Andrade M,Gurgel Cosme do Nascimento E,Pereira W,Fernandes J,Fernandes T Role of lncRNA Alterations in Cervical Oncogenesis. . 2022; 111 - 120. 10.14744/ejmo.2022.74937
IEEE	OLIVIEIRA A,Duarte de Almeida V,Posada T,Estevam Carvalho A,Wojcieszyn V,Andrade M,Gurgel Cosme do Nascimento E,Pereira W,Fernandes J,Fernandes T "Role of lncRNA Alterations in Cervical Oncogenesis." , ss.111 - 120, 2022. 10.14744/ejmo.2022.74937
ISNAD	OLIVIEIRA, Alan Lopes de Oliveira vd. "Role of lncRNA Alterations in Cervical Oncogenesis". (2022), 111-120. https://doi.org/10.14744/ejmo.2022.74937

APA	OLIVIEIRA A, Duarte de Almeida V, Posada T, Estevam Carvalho A, Wojcieszyn V, Andrade M, Gurgel Cosme do Nascimento E, Pereira W, Fernandes J, Fernandes T (2022). Role of lncRNA Alterations in Cervical Oncogenesis. Eurasian Journal of Medicine and Oncology, 6(2), 111 - 120. 10.14744/ejmo.2022.74937
Chicago	OLIVIEIRA Alan Lopes de Oliveira,Duarte de Almeida Valeria,Posada Tauê,Estevam Carvalho Aline,Wojcieszyn Victor,Andrade Micassio,Gurgel Cosme do Nascimento Ellany,Pereira Wogelsanger,Fernandes José Veríssimo,Fernandes Thales Role of lncRNA Alterations in Cervical Oncogenesis. Eurasian Journal of Medicine and Oncology 6, no.2 (2022): 111 - 120. 10.14744/ejmo.2022.74937
MLA	OLIVIEIRA Alan Lopes de Oliveira,Duarte de Almeida Valeria,Posada Tauê,Estevam Carvalho Aline,Wojcieszyn Victor,Andrade Micassio,Gurgel Cosme do Nascimento Ellany,Pereira Wogelsanger,Fernandes José Veríssimo,Fernandes Thales Role of lncRNA Alterations in Cervical Oncogenesis. Eurasian Journal of Medicine and Oncology, vol.6, no.2, 2022, ss.111 - 120. 10.14744/ejmo.2022.74937
AMA	OLIVIEIRA A,Duarte de Almeida V,Posada T,Estevam Carvalho A,Wojcieszyn V,Andrade M,Gurgel Cosme do Nascimento E,Pereira W,Fernandes J,Fernandes T Role of lncRNA Alterations in Cervical Oncogenesis. Eurasian Journal of Medicine and Oncology. 2022; 6(2): 111 - 120. 10.14744/ejmo.2022.74937
Vancouver	OLIVIEIRA A,Duarte de Almeida V,Posada T,Estevam Carvalho A,Wojcieszyn V,Andrade M,Gurgel Cosme do Nascimento E,Pereira W,Fernandes J,Fernandes T Role of lncRNA Alterations in Cervical Oncogenesis. Eurasian Journal of Medicine and Oncology. 2022; 6(2): 111 - 120. 10.14744/ejmo.2022.74937
IEEE	OLIVIEIRA A,Duarte de Almeida V,Posada T,Estevam Carvalho A,Wojcieszyn V,Andrade M,Gurgel Cosme do Nascimento E,Pereira W,Fernandes J,Fernandes T "Role of lncRNA Alterations in Cervical Oncogenesis." Eurasian Journal of Medicine and Oncology, 6, ss.111 - 120, 2022. 10.14744/ejmo.2022.74937
ISNAD	OLIVIEIRA, Alan Lopes de Oliveira vd. "Role of lncRNA Alterations in Cervical Oncogenesis". Eurasian Journal of Medicine and Oncology 6/2 (2022), 111-120. https://doi.org/10.14744/ejmo.2022.74937