TY  - JOUR
TI  - Role of lncRNA Alterations in Cervical Oncogenesis
AB  - Objectives: Human Papillomavirus (HPV) is the main contributor to the development of cervical cancer. This study 
aimed to investigate the biological significance of changes in the expression of lncRNAs induced by HPV oncoproteins 
in cervical oncogenesis mechanisms.
Methods: We performed a review using online databases. The alterations were associated with some molecular and/or 
cellular characteristics that could be involved in the pathogenesis of cervical cancer. The molecular targets of the RNAs 
were identified using the Gene Expression Profiling Interactive Analysis (GEPIA) bioinformatics sites/tools, GeneCards®, 
OMIM, and Lnc2Cancer 3.0.
Results: Sixty-one altered lncRNAs were identified. The alterations contribute to the higher staging of cervical cancer 
and a worse prognosis. These lncRNAs can act by competing for miRNAs for response elements, influencing the regulation of target genes and, ultimately, participating in the cancer regulation process and exhibit multiple biological functions, such as chromatin modification, transcription, translation, splicing, and epigenetic regulation.
Conclusion: Changes in lncRNA expression have been associated with the onset, progression, and prognosis of 
cervical cancer. These changes can contribute to several features of cervical oncogenesis, and their identification has 
the potential to provide new biomarkers and therapeutic targets for the treatment of this cancer.
AU  - OLIVIEIRA, Alan Lopes de Oliveira
AU  - Fernandes, Thales
AU  - Duarte de Almeida, Valeria
AU  - Wojcieszyn, Victor
AU  - Estevam Carvalho, Aline
AU  - Andrade, Micassio
AU  - Gurgel Cosme do Nascimento, Ellany
AU  - Fernandes, José Veríssimo
AU  - Posada, Tauê
AU  - Pereira, Wogelsanger
DO  - 10.14744/ejmo.2022.74937
PY  - 2022
JO  - Eurasian Journal of Medicine and Oncology
VL  - 6
IS  - 2
SN  - 2587-2400
SP  - 111
EP  - 120
DB  - TRDizin
UR  - http://search/yayin/detay/531289
ER  -