TY  - JOUR
TI  - Utility of EORTC and CUETO Scoring Models in the Estimation 
of Recurrence and Progression of Non-Muscle-Invasive 
Bladder Cancer
AB  - Objectives: Worldwide, Non-Muscle-Invasive Bladder Cancer (NMIBC) patients are characterized by a high rate of recurrence and progression highlighting the need for a valuable prognostic estimation for better management of this 
disease. Thus, the present preliminary study was planned to evaluate the validation of the European Organization for 
Research and Treatment of Cancer (EORTC) and the Spanish Urological Club for Oncological Treatment (CUETO) risk 
tables to predict recurrence and progression in Moroccan patients with NMIBC.
Methods: A total of 56 NMIBC patients that have undergone transurethral resection of bladder tumor (TURBT), between January 2017 and May 2021, were recruited. The recurrence and progression rates at 1 and 5 years were calculated for each patient using EORTC and CUETO scoring models and compared to EORTC and CUETO risk tables. KaplanMeier was performed to validate stratification and difference between the four groups obtained. A univariate analysis 
using the Cox regression test was realized to evaluate the association between prognostic factors with recurrence and 
progression of the disease.
Results: For the 56 NMIBC patients, the median follow-up duration was 49.68 months. In this cohort, 43 patients had 
recurrent tumors, and 27 showed progression to an advanced stage and/or grade. At 1-year progression and recurrence 
rates were higher than the values predicted by the EORTC and CUETO risk tables, while both tables overestimate the 
long-term risk probabilities of recurrence and progression. Only the CUETO model successfully stratified our patients 
with statistically significant differences between the four groups of recurrence (p=0.005). Of particular interest, univariate Cox analysis indicated that only prior recurrence rate had a significant effect on both recurrence-free survival 
(p=0.04) and progression-free survival (p=0.037).
Conclusion: CUETO scoring model is better than EORTC for recurrence stratification in Moroccan patients with 
NMIBC. Both models overestimate risk in 1-year and underestimate risk in 5-years. A prospective study should be 
realized in large cohorts to establish an ideal prognosis model for Moroccan NMIBC patients.
AU  - Attaleb, Mohammed
AU  - EL AHANIDI, Hajar
AU  - AMEUR, Ahmed
AU  - HASSAN, Ilias
AU  - BOUZIDI, ABDERRAHMANE
AU  - FILALI-MALTOUF, Abdelkarim
AU  - chaoui, imane
AU  - EL AZZOUZI, MERYEM
AU  - OUKABLI, Mohamed
AU  - El Mzibri, Mohammed
AU  - bensaid, Mounia
AU  - TETOU, Mohammed
AU  - BENBACER, Laila
AU  - Hafidi Alaoui, Chaimae
DO  - 10.14744/ejmo.2022.99203
PY  - 2022
JO  - Eurasian Journal of Medicine and Oncology
VL  - 6
IS  - 2
SN  - 2587-2400
SP  - 121
EP  - 129
DB  - TRDizin
UR  - http://search/yayin/detay/531291
ER  -