TY  - JOUR
TI  - The Incidence of Composite Lymphomas: Case Studies 
Anddisease Management
AB  - Objectives: Composite lymphomas (CL), which are a combination of different types of lymphomas in a single patient 
can occur simultaneously or sequentially. Diagnosis and treatment of CL require a full range of modern approaches.
Methods: The study included 37 cases of CL (M:F=2:1), the median age of patients was 64 (38-83 years). All patients underwent a full range of diagnostic procedures, including histopathological, immunohistochemical/immunophenotypic 
(flow cytometry), cytogenetic/FISH, and molecular tests at the National Research Centre for Hematology, Moscow.
Results: Metachronous CL were observed in 17 cases and the most common type of the second lymphoma was diffuse 
large B-cell lymphoma (DLBCL) or Hodgkin's lymphoma (HL). In 30% of cases, DLBCL developed after HL therapy, and 
in 30% - after therapy of angioimmunoblastic T-cell lymphoma (AITL). In 20 cases of synchronous CL the most common 
was B-cell chronic lymphocytic leukemia (B-CLL) combined with hairy cell leukemia (HCL) - 54.5%, large granular lymphocytic leukemia, marginal zone lymphoma (MZL), follicular lymphoma, multiple myeloma, or mycosis fungoides. A 
combination of HL with other lymphoma was observed in 25% of cases (HL+MZL represent 60% of cases).
Conclusion: CL are excellent models for studying the complex process of tumor cells evolution during the course of the 
disease. Treatment of CL is a non-trivial task and aims to control both diseases.
AU  - Biderman, Bella
AU  - Sidorova, Yulia
AU  - Kovrigina, Alla
AU  - Al-Radi, Liubov
AU  - Dorokhina, E.I.
AU  - Nikulina, Lena
AU  - Moiseeva, Tatiana N.
AU  - ZAHARKO, Ekaterina
AU  - Smirnova, Svetlana
AU  - Plastinina, Lyubov
AU  - Sudarikov, Andrey
AU  - Kravchenko, Sergey
DO  - 10.14744/ejmo.2022.14882
PY  - 2022
JO  - Eurasian Journal of Medicine and Oncology
VL  - 6
IS  - 2
SN  - 2587-2400
SP  - 130
EP  - 136
DB  - TRDizin
UR  - http://search/yayin/detay/531294
ER  -