TY  - JOUR
TI  - Immunohistochemical Evaluation of CD10 Expression in Oral 
Epithelial Dysplasia and Oral Squamous Cell Carcinoma:
A Cross-sectional Study
AB  - Objectives: The objective of the study is to evaluate the expression of CD10 in oral epithelial dysplasia and oral squamous cell carcinoma (OSCC) and to determine its role as a potential biomarker in OSCC.
Methods: Immunohistochemical evaluation of 40 archival paraffin-embedded tissue specimens grouped into oral epithelial dysplasia and early invasive, well-differentiated, and moderately differentiated OSCC was conducted to determine and compare the CD10 expression among the groups. Stromal positivity of the CD10 expression was calculated 
and statistically analyzed at p<0.05.
Results: The results of the study showed that there was a statistically significant increase in the mean CD10 expression 
among the four groups. Intergroup comparison showed a statistically significant difference between oral epithelial 
dysplasia and OSCC while statistical significance was not observed in the various grades of OSCC.
Conclusion: CD10 expression could be used as an important biomarker for determining the progression of oral 
epithelial dysplasia and the overall prognosis of OSCC.
AU  - Sridharan, Gokul
AU  - KHETAN, PALAK
AU  - Patankar, Sangeeta
DO  - 10.14744/ejmo.2022.15830
PY  - 2022
JO  - Eurasian Journal of Medicine and Oncology
VL  - 6
IS  - 2
SN  - 2587-2400
SP  - 137
EP  - 141
DB  - TRDizin
UR  - http://search/yayin/detay/531295
ER  -